Serial measures of circulating biomarkers of dairy fat and total and cause-specific mortality in older adults: the Cardiovascular Health Study

Otto, Marcia C. de Oliveira; Lemaître, Rozenn N.; Song, Xiaoling; King, Irena B.; Siscovick, David S.; Mozaffarian, Dariush

doi:10.1093/ajcn/nqy117

Cited by 40 publications

(43 citation statements)

References 63 publications

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“…Polyunsaturated FAs, such as C20:3 (n-6), C20:4 (n-6), C20:5 (n-3), C22:5 (n-3), C22:6 (n-6), were essentially absent from both cow and goat milk samples. As discussed in the introduction, it is becoming clear that each particular FA may play a different role in human health [6,[16][17][18]. In the case of saturated FAs, odd-chain saturated C15:0 and C17:0 have shown to be associated with a lower risk of type 2 diabetes [18].…”

Section: (A)mentioning

confidence: 99%

“…However, recently Astrup and colleagues argued that these guidelines fail to take into account considerable evidence that the health effects vary for different types of saturated FAs and that the composition of the food source is crucially important [16]. It has been demonstrated that the high circulating odd-chain saturated fatty acid C17:0 is inversely associated with CVD and stroke mortality and potentially associated with higher risk of non-CVD death [17]. A recent large meta-analysis, which pooled the findings from 16 prospective cohort studies, has shown that higher levels of odd-chain saturated fatty acids C15:0 and C17:0 are associated with a lower risk of type 2 diabetes (T2D) [18].…”

Section: Introductionmentioning

confidence: 99%

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Development of a Liquid Chromatography–High Resolution Mass Spectrometry Method for the Determination of Free Fatty Acids in Milk

2020

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The determination of free fatty acids (FFAs) in milk is of importance for quality control, legislative purposes, authentication and product development. We present herein a liquid chromatography–high resolution mass spectrometry method for the direct determination of FFAs in milk. The method involves mild sample preparation, avoids time-consuming derivatization and allows the direct quantification of twenty-two FFAs in a 10-min single run. It was validated and applied in thirteen cow milk and seven goat milk samples. Saturated fatty acids C16:0, C18:0 and unsaturated C18:1 (n-9) were found to be the major components of milk FFAs at concentrations of 33.1 ± 8.2 μg/mL, 16.5 ± 5.3 μg/mL and 14.8 ± 3.8 μg/mL, respectively, in cow milk and at concentrations of 22.8 ± 1.8 μg/mL, 12.7 ± 2.8 μg/mL and 13.3 ± 0.3 μg/mL, respectively, in goat milk. Other saturated and unsaturated FFAs were found in significantly lower quantities. Saturated fatty acids C6:0, C8:0 and C10:0 were found in higher quantities in goat milk than in cow milk. The levels of the important (for human health) odd-chain FFAs C15:0 and C17:0 were estimated in cow and goat milk.

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Section: (A)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of a Liquid Chromatography–High Resolution Mass Spectrometry Method for the Determination of Free Fatty Acids in Milk

2020

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“…For example, people tend to overestimate the intake of foods perceived as healthy and underreport the intake of foods perceived as less healthy (45) . Several fatty acids (C14 : 0, C15 : 0, C17 : 0 and trans-C16 : 1n-7) have been used as biomarkers of dairy intake (46)(47)(48) to overcome the shortcomings of FFQ. Combining the classic dietary assessment with validated dairy biomarkers may improve the robustness of dietary assessment in epidemiological studies.…”

Section: The Present Studymentioning

confidence: 99%

The association between milk consumption and the metabolic syndrome: a cross-sectional study of the residents of Suzhou, China and a meta-analysis

Hidayat

Yu²,

Yang

et al. 2020

Br J Nutr

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The association between milk consumption and the metabolic syndrome remains inconclusive, and data from Chinese populations are scarce. We conducted a cross-sectional study to investigate the association between milk consumption and the metabolic syndrome and its components among the residents of Suzhou Industrial Park, Suzhou, China. A total of 5149 participants were included in the final analysis. A logistic regression model was applied to estimate the OR and 95 % CI for the prevalence of the metabolic syndrome and its components according to milk consumption. In addition, the results of our study were further meta-analysed with other published observational studies to quantify the association between the highest v. lowest categories of milk consumption and the metabolic syndrome and its components. There was no significant difference in the odds of having the metabolic syndrome between milk consumers and non-milk consumers (OR 0·86, 95 % CI 0·73, 1·01). However, milk consumers had lower odds of having elevated waist circumference (OR 0·78, 95 % CI 0·67, 0·92), elevated TAG (OR 0·83, 95 % CI 0·70, 0·99) and elevated blood pressure (OR 0·85, 95 % CI 0·73, 0·99). When the results were pooled together with other published studies, higher milk consumption was inversely associated with the risk of the metabolic syndrome (relative risk 0·80, 95 % CI 0·72, 0·88) and its components (except elevated fasting blood glucose); however, these results should be treated with caution as high heterogeneity was observed. In summary, the currently available evidence from observational studies suggests that higher milk consumption may be inversely associated with the metabolic syndrome.

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“…The result of a prospective cohort study in the United States on 2907 people over the age of 65 has been shown that there were no signi cant relationship between pentadecanoic, heptadecanoic and trans-palmitoleic phospholipids (as biomarkers of dairy fat intake) with total mortality and incidence of CVDs [30]. In another meta-analysis study of 13 studies, it was observable that higher intake of dairy fat was not associated with an increased risk of cardiovascular disease [31] .…”

Section: Buttermentioning

confidence: 99%

The Effect of Edible Lipids on Atherogenic Index of Plasma: Results From RaNCD Cohort Study

Sahargahi

Pasdar

Moradinazar

et al. 2020

Preprint

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Background: The amount and type of lipids consumed has a great impact on serum lipid profile and risk of cardiovascular diseases (CVDs). A novel index named atherogenic index of plasma (AIP) is better predictors of CVD risk factors than lipids alone. This study aimed to investigate the effect of edible oils on AIP. Methods: This cross-sectional study conducted on preliminary phase of Ravansar Non-Communicable Disease (RaNCD) cohort study. The amount of consumption of edible lipids was determined based on validated Food Frequency Questionnaire (FFQ). Lipid profiles including triglyceride (TG), and lipoprotein cholesterol (HDL-C) were measured, and AIP was calculated as log10 (TG/HDL-C).Results: A total of 9996 individuals, 4738(47.4%) were male. The mean of AIP was 0.98±0.6 (range from -1.73 to 4.15) that in females (0.97 ± 0.6) was lower than males (1.10 ± 0.6). After controlling for confounding and affecting variables, the AIP index decreased with increasing consumption of a local oil named Kermanshahi oil [β(CI 95% ): -0.006(-0.008, -0.003)], butter[β(CI 95% ): -0.008(-0.011, -0.005)] and not statistically significant decrease with Hydrogenated or partial hydrogenated oil [β(CI 95% ): -0.008(-0.001, 0.001)] but the AIP index increased with un-hydrogenated oil [β(CI 95% ): 0.001(-0.001, 0.001)]Conclusion: Kermanshahi oil and butter have decreasing effect on AIP, the effect of margarine was neutral, hydrogenated vegetable oil has trace decreasing effect whereas un-hydrogenated vegetable oil has increasing effect on it. So, consumption of Kermanshahi oil may be associated with lower cardiovascular risk.

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Serial measures of circulating biomarkers of dairy fat and total and cause-specific mortality in older adults: the Cardiovascular Health Study

Cited by 40 publications

References 63 publications

Development of a Liquid Chromatography–High Resolution Mass Spectrometry Method for the Determination of Free Fatty Acids in Milk

Development of a Liquid Chromatography–High Resolution Mass Spectrometry Method for the Determination of Free Fatty Acids in Milk

The association between milk consumption and the metabolic syndrome: a cross-sectional study of the residents of Suzhou, China and a meta-analysis

The Effect of Edible Lipids on Atherogenic Index of Plasma: Results From RaNCD Cohort Study

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