The role of 3D fusion imaging in sentinel lymphadenectomy for vulvar cancer

Beneder, C.; Fuechsel, Frank G.; Krause, T.; Kuhn, Ann M.; Mueller, Michael D.

doi:10.1016/j.ygyno.2007.11.045

Cited by 40 publications

(25 citation statements)

References 19 publications

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“…The use of SPECT/CT has been described in SLN lymphadenectomy for breast cancer, head and neck cancers, melanoma, prostate and bladder cancers, vulvar, cervical and endometrial cancers -the value of SPECT/CT for SLN identification and localization has been described in several reports [6,31,33,[44][45][46][47][48][49]. In special instances, SPECT/CT imaging allows for improved detectability and interpretation of lymphatic drainage.…”

Section: Discussionmentioning

confidence: 99%

Sentinel lymph nodes and planar scintigraphy and SPECT/CT in various types of tumours. Estimation of some factors influencing detection success

Kraft

Havel²

2013

Nucl. Med. Rev.

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Section: Discussionmentioning

confidence: 99%

Sentinel lymph nodes and planar scintigraphy and SPECT/CT in various types of tumours. Estimation of some factors influencing detection success

Kraft

Havel²

2013

Nucl. Med. Rev.

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“…Sherif et al reported on the use of SPECT/CT in 6 patients with bladder cancer (18) and concluded that the addition of SPECT/CT could markedly increase the detection of sentinel nodes. Beneder et al reported that the use of SPECT/CT in vulvar cancer revealed additional information in 7 of 10 patients (19). With regard to the use of SPECT/CT in prostate cancer, Kizu et al were the first to describe fusion of images from those 2 modalities (20).…”

Section: Discussionmentioning

confidence: 99%

Value of SPECT/CT for Detection and Anatomic Localization of Sentinel Lymph Nodes Before Laparoscopic Sentinel Node Lymphadenectomy in Prostate Carcinoma

Vermeeren¹,

Olmos²,

Meinhardt³

et al. 2009

J Nucl Med

105

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Laparoscopic evaluation of sentinel nodes is useful for staging prostate cancer, but preoperative localization of deep abdominal sentinel nodes with planar lymphoscintigraphy is difficult. We evaluated the value of SPECT/CT for detecting and localizing sentinel nodes in prostate cancer. Methods: 99m Tc-nanocolloid was injected peri-and intratumorally, guided by transrectal ultrasonography, in 46 patients with prostate cancer of intermediate prognosis. Patients underwent planar imaging after 15 min and 2 h, SPECT/CT after 2 h, and laparoscopic sentinel node lymphadenectomy on the same day. SPECT was fused with CT and analyzed using 2-dimensional orthogonal slicing and 3-dimensional volume rendering. We evaluated the number of extra sentinel nodes found by SPECT/CT, the number of sentinel nodes found by SPECT/CT outside the area of the extended pelvic lymphadenectomy, and the anatomic information provided by SPECT/CT. Furthermore, we classified the value of the additional SPECT/CT images into 3 categories (no advantage, presumable advantage, and definite advantage) according to the extra anatomic information given and whether additional sentinel nodes were found by SPECT/CT. Results: The patients had a mean age of 64 y (range, 53-74 y) and received a mean injected dose of 218 MBq (range, 147-286 MBq). The sentinel node visualization rate was 91% (42 patients) for planar imaging and 98% (45 patients) for SPECT/CT. In 29 of the 46 patients (63%), SPECT/CT revealed additional sentinel nodes (especially lymph nodes near the injection area) not seen on planar imaging. In 7 patients, those additional sentinel nodes were positive for metastasis (being the exclusive metastatic sentinel node in 4 patients). Overall, 15 patients (33%) had positive sentinel nodes. Sentinel nodes outside the area of extended pelvic lymphadenectomy were found in 16 patients (35%), whereas in 56% of these patients those nodes were not seen on planar imaging. Performing SPECT/CT had no advantage in 13% of the patients, a presumable advantage in 24%, and a definite advantage in 63%. Urologic surgeons used the SPECT/CT images to guide their trocar insertion sites and sentinel node finding with the probe. Conclusion: More sentinel nodes can be detected with SPECT/CT than with planar imaging alone. In comparison with planar imaging, SPECT/CT especially reveals extra sentinel nodes near the prostate and outside the area of the extended pelvic lymphadenectomy. Furthermore, the modality provides useful additional information about the anatomic location of sentinel nodes within and outside the pelvic area, leading to improved intraoperative sentinel node identification.

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“…Small studies have been performed in patients with urological and gynecological tumors and the investigators conclude that the new technique increases the yield of sentinel nodes [44][45][46]. We examined the use of additional SPECT/CT in 46 sentinel node procedures for prostate cancer [47].…”

Section: Spect/ct In Patients With Other Malignanciesmentioning

confidence: 99%

SPECT/CT for preoperative sentinel node localization

Vermeeren

Ploeg

Olmos

et al. 2010

Journal of Surgical Oncology

118

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The value of SPECT/CT for detection and localization of sentinel nodes is reviewed. SPECT/CT depicts extra sentinel nodes and identifies nonnodal tracer accumulation. SPECT/CT is indicated in patients with complex lymphatic drainage as often present in patients with head, neck and scapular melanoma, breast cancer patients with extra-axillary sentinel nodes and patients with tumors draining to pelvic nodes. SPECT/CT also clarifies the drainage pattern of inconclusive conventional images (non-visualization or unclear location of the nodes).

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The role of 3D fusion imaging in sentinel lymphadenectomy for vulvar cancer

Cited by 40 publications

References 19 publications

Sentinel lymph nodes and planar scintigraphy and SPECT/CT in various types of tumours. Estimation of some factors influencing detection success

Sentinel lymph nodes and planar scintigraphy and SPECT/CT in various types of tumours. Estimation of some factors influencing detection success

Value of SPECT/CT for Detection and Anatomic Localization of Sentinel Lymph Nodes Before Laparoscopic Sentinel Node Lymphadenectomy in Prostate Carcinoma

SPECT/CT for preoperative sentinel node localization

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