SPECT/CT for preoperative sentinel node localization

Vermeeren, Lenka; Ploeg, Iris M. C. van der; Olmos, Renato A. Valdés; Meinhardt, W.; Klop, W. Martin C.; Kroon, Bin B. R.; Nieweg, Omgo E.

doi:10.1002/jso.21439

Cited by 118 publications

(69 citation statements)

References 41 publications

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“…25) They found that SPECT/CT for SN mapping brought precise localization with three-dimensional imaging. Application of SPECT/CT to SN mapping might improve detection and localization even in esophageal cancer.…”

Section: Results Of Sentinel Node Biopsy For Esophageal Cancermentioning

confidence: 99%

Sentinel Node Navigation Surgery in Early-Stage Esophageal Cancer

Takeuchi¹,

Kawakubo²,

Takeda³

et al. 2012

ATCS

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The sentinel node (SN) concept has revolutionized the surgical staging of both melanoma and breast cancer over the past two decades. However, the validity of the SN hypothesis has been controversial for esophageal cancer, because SN mapping for esophageal cancer is technically complicated, and the number of early-stage esophageal cancer is very limited. Nevertheless previous studies nicely demonstrated that SN mapping may be feasible in patients with earlystage esophageal cancer. Transthoracic extended esophagectomy with three-field radical lymph node dissection has been recognized as a curative procedure for thoracic esophageal cancer in Japan. However, uniform application of this highly invasive procedure might increase the morbidity and markedly reduce the quality of life (QOL) after surgery. Although further accumulation of evidence based on multicenter clinical trials using a standard protocol is needed, SN mapping and SN navigation surgery would provide significant information to perform individualized selective lymphadenectomy which might reduce the morbidity and retain the patients' QOL. In addition, technical innovation including the development of new tracers is expected to confirm the accuracy and reliability of SN mapping in esophageal cancer.

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Section: Results Of Sentinel Node Biopsy For Esophageal Cancermentioning

confidence: 99%

Sentinel Node Navigation Surgery in Early-Stage Esophageal Cancer

Takeuchi¹,

Kawakubo²,

Takeda³

et al. 2012

ATCS

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“…In this region, there are more complex lymphatic drainage patterns involving multiple lymph node basins, and the success of identifying SLNs may be lower than in other regions, particularly when the surgeon has less experience with head and neck SLNB. It has been proposed that the higher-resolution, three-dimensional images achieved with SPECT/CT imaging may enhance detection of SLNs and decrease risks by limiting the dissection necessary for SLNB [Even-Sapir et al, 2003;Roarke et al, 2007;Vermeeren et al, 2010], but this remains to be determined. Patients should be informed that an attempted SLNB may be unsuccessful, in which case the risks, cost, and discomfort associated with the procedure are incurred without added benefit to wide excision alone.…”

Section: Slnb For Head and Neck Melanomasmentioning

confidence: 99%

“…However, depending on the circumstances, a second injection may pose significant logistical problems for the patient, operating room, and surgeon. Alternatively, the procedure may be postponed in favor of repeating lymphoscintigraphy with SPECT/CT imaging, which provides a finer, threedimensional image of lymphatic drainage and may enhance the ability to detect SLNs in the setting of complex drainage patterns [van der Ploeg et al, 2009;Vermeeren et al, 2010]. This is more resource-intensive, however, and SPECT/CT imaging is not available at all institutions that offer lymphoscintigraphy.…”

Section: Complex Drainage Patters or Failure To Localize Sentinel Lymmentioning

confidence: 99%

Challenging Problems in the Surgical Management of Melanoma

Ganapathi¹,

Tyler²,

Mosca³

2011

Current Management of Malignant Melanoma

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“…[7] Since its introduction, hybrid SPECT/CT has been known as the most reliable imaging technique for showing the exact locations of SNs. [8] However, this new technology is only available at a few hospitals because of the high cost of the instrumentation. Thus, software-based coregistration of SPECT and CT images is still considered to be useful and more cost effective.…”

Section: Introductionmentioning

confidence: 99%

CT and SPECT image fusion using external fiducial markers for detection of the sentinel lymph nodes in breast cancer

Haramiishi

Nakamura

Tsuchiya

et al. 2017

IJDI

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Object: Hybrid single-photon emission computed tomography/computed tomography, which is recently developed, is useful for the sentinel node (SN) mapping in patients with breast cancer. However, this expensive new technology is only available at limited hospitals. The purpose of this study was to assess the feasibility of software-based computed tomography (CT) and single-photon emission tomography (SPECT) image fusion using external fiducial markers for visualization of SNs in breast cancer.Methods: Preoperative lymphoscintigraphy using 99mTc-phytate colloid was performed in 70 consecutive patients (mean age, 55.3 ± 11.8). Continually, SPECT and low-dose chest CT were performed using an 241Am-containing button as an external fiducial marker attached to the skin surface of the patient’s chest wall. The acquired SPECT and CT images were rescaled, interpolated, reformatted, and registered point-by-point on a workstation.Results: SPECT detected SN sites, including axillar (n = 96) and internal mammary lesions (n = 7). On fused images, precise overlap of hot spots shown at the corresponding lymph nodes on CT images was achieved in all but 2 cases. In cases with axillar lesions, rendering the fused images into 3D volumes with accentuation of the pectoralis minor muscle was helpful for diagnosis of SN locations in level II (n = 10). After surgery, all nodes were depicted as “hot nodes” on fused images, and 14 metastatic nodes were confirmed by histological examination.Conclusions: External fiducial-based coregistration of SPECT lymphoscintigraphic and CT images depicted the precise location of SN drainage and may provide useful information for preoperative planning, without the need for hybrid SPECT/CT.

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SPECT/CT for preoperative sentinel node localization

Cited by 118 publications

References 41 publications

Sentinel Node Navigation Surgery in Early-Stage Esophageal Cancer

Sentinel Node Navigation Surgery in Early-Stage Esophageal Cancer

Challenging Problems in the Surgical Management of Melanoma

CT and SPECT image fusion using external fiducial markers for detection of the sentinel lymph nodes in breast cancer

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