The role of 11C-choline positron emission tomographycomputed tomography and videomediastinoscopy in the evaluation of diseases of middle mediastinum

Liu, Qi; Peng, Zhongmin; Liu, Qingwei; Yao, Shuzhan; Zhang, Lin; Meng, Long; Chen, Jinghan

doi:10.1097/00029330-200604020-00004

Cited by 20 publications

(7 citation statements)

References 9 publications

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“…For these reasons, all supradiaphragmatic findings call for directed histologic study [28,29]. In our series, the histologic results confirmed that the hypermetabolic foci with increased activity in delayed imaging were malignant and those with decreased activity were reactive (Fig.…”

Section: Discussionsupporting

confidence: 79%

Dual-phase 11C-choline PET/computed tomography in the early evaluation of prostate cancer recurrence

García

Cuberas

Riera

et al. 2015

Nuclear Medicine Communications

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Section: Discussionsupporting

confidence: 79%

Dual-phase 11C-choline PET/computed tomography in the early evaluation of prostate cancer recurrence

García

Cuberas

Riera

et al. 2015

Nuclear Medicine Communications

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“…11 C-Choline was evaluated for differentiation of lung cancer and other lesions including active TB [ 66 , 104 , 105 ]. While 75 % accuracy was found when using 11 C-choline alone for this differentiation, combining 11 C-choline and F-FDG appeared to yield better results [ 105 ].…”

Section: Diagnosis Of Tuberculosismentioning

confidence: 99%

PET/CT imaging of Mycobacterium tuberculosis infection

Ankrah

Werf

Vries

et al. 2016

Clin Transl Imaging

104

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Tuberculosis has a high morbidity and mortality worldwide. Mycobacterium tuberculosis (Mtb) has a complex pathophysiology; it is an aerobic bacillus capable of surviving in anaerobic conditions in a latent state for a very long time before reactivation to active disease. In the latent tuberculosis infection, the individual has no clinical evidence of active disease, but exhibits a hypersensitive response to proteins of Mtb. Only some 5–10 % of latently infected individuals appear to have reactivation of tuberculosis at any one time point after infection, and neither imaging nor immune tests have been shown to predict tuberculosis reactivation reliably. The complex pathology of the organism provides multiple molecular targets for imaging the infection and targeting therapy. Positron emission tomography (PET) integrated with computer tomography (CT) provides a unique opportunity to noninvasively image the whole body for diagnosing, staging and assessing therapy response in many infectious and inflammatory diseases. PET/CT is a powerful noninvasive tool that can rapidly provide three-dimensional views of disease deep within the body and conduct longitudinal assessment over time in one particular patient. Some PET tracers, such as 18F-fluorodeoxyglucose (18F-FDG), have been found to be useful in various infectious diseases for detection, assessing disease activity, staging and monitoring response to therapy. This tracer has also been used for imaging tuberculosis. 18F-FDG PET relies on the glucose uptake of inflammatory cells as a result of the respiratory burst that occurs with infection. Other PET tracers have also been used to image different aspects of the pathology or microbiology of Mtb. The synthesis of the complex cell membrane of the bacilli for example can be imaged with 11C-choline or 18F-fluoroethylcholine PET/CT while the uptake of amino acids during cell growth can be imaged by 3′-deoxy-3′-[18F]fluoro-l-thymidine. PET/CT provides a noninvasive and sensitive method of assessing histopathological information on different aspects of tuberculosis and is already playing a role in the management of tuberculosis. As our understanding of the pathophysiology of tuberculosis increases, the role of PET/CT in the management of this disease would become more important. In this review, we highlight the various tracers that have been used in tuberculosis and explain the underlying mechanisms for their use.

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“…Although essentially beyond the scope of this review, it should be noted that various other PET tracers have been investigated for imaging of TB, including 11 C-choline [46][47][48], 18 F-FLT [49,50], and 68 Ga-citrate, with some promising results, for example prediction of the nature of a solitary pulmonary nodule with 11 C-choline.…”

Section: Other Pet Tracers and Potential Applicationsmentioning

confidence: 99%