Advances in imaging of tuberculosis

Vorster, Mariza; Sathekge, Mike; Bomanji, Jamshed

doi:10.1097/mcp.0000000000000043

Cited by 101 publications

(39 citation statements)

References 45 publications

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“…Although most reports described in the literature deal with detection of infection in the lungs [14,15] and the skeletal system [16][17][18], FDG-PET has been shown to be just as successful in other locations throughout the body [14]. The data published in the literature are very convincing and clearly demonstrate the critical role that this tracer can play in effective management of many common infectious disorders.…”

supporting

confidence: 54%

FDG-PET imaging to detect and characterize infectious disorders; an unavoidable path for the foreseeable future

Alavi

Werner

2016

Eur J Nucl Med Mol Imaging

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supporting

confidence: 54%

FDG-PET imaging to detect and characterize infectious disorders; an unavoidable path for the foreseeable future

Alavi

Werner

2016

Eur J Nucl Med Mol Imaging

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“…The diagnosis of active PTB is a major challenge; such patients characteristically demonstrate an atypical radiographic pattern [22], like middle and lower lung lobes involvement, absence of cavity formation, presence of lymphadenopathy (LAD) and pleural effusion or miliary pattern [29]. The chest X-ray is usually normal because of attenuation of inflammatory signs by neutropenia.…”

Section: Diagnosismentioning

confidence: 99%

Diagnostic Delay and Associated Clinical Features of Tuberculosis among Adult Patients with Acute Myeloid Leukemia in Doha, Qatar

Omri¹,

Taha²,

Ibrahim³

et al. 2018

JTR

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Background: Tuberculosis is currently the world's leading cause of death arising from a single infectious condition. While T cell mediated immunity is recognized to have a major contribution to tuberculosis activation, the present investigation confirmed that TB was more prevalent among patients with acute myeloid rather than lymphoid leukemia and such association was frequently overlooked. The primary objective of this study is to estimate the diagnostic delay of tuberculosis among patients with acute myeloid leukemia (AML) and compare it to the general population in Qatar. Secondary objective is to study the clinical and epidemiologic characteristics of tuberculosis in patients with AML. Methods: This is a retrospective study of tuberculosis cases diagnosed in subjects with AML during the period from January 2008 till December 2016. Results: Among 215 subjects with AML identified during the study period, 12 (5.58%) received the diagnosis of tuberculosis. The estimated incidence of tuberculosis among AML cases was 7.14 cases per 1000 per year. The mean delay in diagnosis of tuberculosis was 64.2 days (95% CI: 26.8 -101.5) and the median was 45 days (interquartile range; Q1 -Q3, 29.5 -97.5). Prolonged fever was the most common presentation (100% of cases). Parenchymal lung involvement was the most common radiologic abnormality (83.3% of cases). Three patients (25%) died and 8 patients completed 9 to 12 months of anti-tuberculous treatment with clinical and radiological remission. Conclusion: Infections caused by Mycobacterium tuberculosis are not How to cite this paper: El Omri, H., Taha, R., Ibrahim, W., Kassem, N., Szabados, L., El Sabah, H., Abid, F.B., Gamiel, A., Al Khinji, A., Szmeigielski, W., Hasan, S. and Al Hijji, I. (2018

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“…LNTB is typically drained from PTB through the lymphatics (9); following intense interaction between mycobacterial virulence and individual response in the tuberculous lymph nodes, the monocytes, the macrophages, the lymphocytes, the epithelial cells and the other chronic inflammatory cells will accumulate. The activated inflammatory cells, similarly to cancer cells, may then markedly increase glycolysis (5,27). The hexose monophosphate shunt is stimulated by phagocytosis, with increases of 20–30 times that of baseline values, thereby increasing FDG uptake (5).…”

Section: Discussionmentioning

confidence: 99%

“…To solve this, various other PET tracers have been investigated, including 11 C-choline (29), 18 F-FLT (30,31), 68 Ga-citrate (27), with some promising results. For example, Hara et al (29) compared 18 F-FDG vs. 11 C-choline uptake in cancer and TB in their study, concluding that whereas lesions report elevated 18 F-FDG uptake, only cancer shows high uptake with choline, and TB lesions are hardly visualized.…”

Section: Discussionmentioning

confidence: 99%

Lymph node tuberculosis mimicking malignancy on 18F-FDG PET/CT in two patients: A case report

Ding

Cao

et al. 2017

Experimental and Therapeutic Medicine

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18F-fluorodeoxyglucose positron emission/computed tomography (18F-FDG PET/CT) imaging, an established procedure for evaluation of malignancy, reports an increased 18F-FDG uptake in acute or chronic inflammatory condition. Lymph node tuberculosis (LNTB) is the most common form of extrapulmonary tuberculosis. However, the absence of clinical symptoms and bacteriological basis makes it difficult to diagnose. In the current case report, two patients with LNTB mimicking malignant lymphoma are presented by 18F-FDG PET/CT. The objective of the present report is to emphasize that LNTB should be considered as a noteworthy differential diagnosis in patients with enlarged lymph nodes, particularly in tuberculosis-endemic countries, and that lymph node biopsy serves a vital role in diagnosing LNTB.

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Advances in imaging of tuberculosis

Abstract: ¹⁸F-FDG PET and PET/CT may assist early diagnosis and facilitate differentiation between malignancies and TB, identification of extrapulmonary TB, staging of TB, and assessment of treatment response.

Cited by 101 publications

References 45 publications

FDG-PET imaging to detect and characterize infectious disorders; an unavoidable path for the foreseeable future

FDG-PET imaging to detect and characterize infectious disorders; an unavoidable path for the foreseeable future

Diagnostic Delay and Associated Clinical Features of Tuberculosis among Adult Patients with Acute Myeloid Leukemia in Doha, Qatar

Lymph node tuberculosis mimicking malignancy on 18F-FDG PET/CT in two patients: A case report

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