FDG-PET imaging to detect and characterize infectious disorders; an unavoidable path for the foreseeable future

Nuclear and Optical Bimodal Imaging Probes Using Sequential Assembly: A Perspective

“…1 Nuclear imaging applications have further broadened after approval of the positron emission tomography (PET) tracer, 18 F-fluorodesoxyglucose ( 18 FDG), for the study of abnormal glucose metabolism in the context of cancerous growths, coronary artery disease, and neurological dysfunctions such as seizures in the year 2000. [2][3][4][5] This has led to a continuously increasing SPECT and PET scanner base, which in turn has motivated the development of novel targeted imaging tracers incorporating various positron-emissive radioisotopes onto small molecules, synthetic peptides, and biologics. Furthermore, the incorporation of band a-emitting radionuclides can provide therapeutic analogs to b + /c-based imaging tracers, specifically for personalized medicine applications in oncology, where targeted PET imaging is an indispensable treatment stratification tool.…”

FDG-PET imaging to detect and characterize underlying causes of fever of unknown origin: an unavoidable path for the foreseeable future

“…FDG-PET has shown a great deal of promise in detecting infectious disorders, due to the high expression of glucose transporters (GLUT) in inflammatory cells ( Fig. 1) [11,12]. In developing countries, infections account for the majority of FUO cases, while in developed countries, infectious diseases are the second most common cause of FUO, after non-infectious inflammatory diseases (NIID) [13].…”

Imaging of Postoperative Infection at the Knee Joint

“…Although some authors consider it highly accurate, others have an opposite opinion, considering it inferior to FDG-PET in the diagnosis of periprosthetic hip and knee infections. [72][73][74][75] Leukocyte scans also have decreased sensitivity in the setting of low-grade infection 76 and neutropenia. A total leukocyte count of at least 2,000/mL is needed to obtain satisfactory images.…”

“…80 Additionally, the assessment of global disease activity may further enhance the role of PET during the course of the disease. 75 However, in the United States at the present time, FDG-PET is not approved for reimbursement for the diagnosis of inflammation or infection. A recent commentary in the European Journal of Nuclear Medicine and Molecular Imaging by Alavi and Werner advocated the acceptance of this evolving nuclear imaging modality in the diagnosis and treatment follow-up of musculoskeletal infections as an unavoidable path for the foreseeable future.…”

“…A recent commentary in the European Journal of Nuclear Medicine and Molecular Imaging by Alavi and Werner advocated the acceptance of this evolving nuclear imaging modality in the diagnosis and treatment follow-up of musculoskeletal infections as an unavoidable path for the foreseeable future. 75 Additional investigational nuclear radiotracers that potentially may be useful in the diagnosis of musculoskeletal infections include Tc-99m-labeled interleukin-8 scintigraphy and Tc-99-labeled monoclonal antibody Fab′ fragments (sulesomab). 81,82 Arteaga de Murphy and collaborators investigated the performance of an infection-specific radiolabeled synthetic fragment of the naturally occurring human antimicrobial peptide ubiquicidin, 99mTc-UBI 29-41, in detecting various types mainly musculoskeletal infections in 148 patients.…”