The Role, Involvement and Function(s) of Interleukin-35 and Interleukin-37 in Disease Pathogenesis

Bello, Ramatu Omenesa; Chin, Voon Kin; Isnadi, Mohammad Faruq Abd Rachman; Majid, Roslaini Abd; Abdullah, Maizaton Atmadini; Lee, Tze Yan; Zakaria, Zainul Amiruddin; Hussain, Mohd Khairi; Basir, Rusliza

doi:10.3390/ijms19041149

Cited by 32 publications

(24 citation statements)

References 109 publications

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“…In PBS-dosed ADR-159 fed animals, we observed a reduced expression of IL-12α. IL-12α (p35) is a subunit of a pleiotropic cytokine IL-12 (see above) and at the same time a subunit of IL-35 (together with IL-27β), an immune-suppressing cytokine that has a role in inhibition of arthritis, asthma, and IBD (Behzadi et al, 2016;Bello et al, 2018). In view of these considerations, a reduced expression of IL-12α in PBS-dosed ADR-159 fed animals could lead to dual effects, as both pro-and anti-inflammatory effects can be anticipated.…”

Section: Effect Of Adr-159 On Citrobacter-induced Colitismentioning

confidence: 99%

Oral Administration of Heat-Treated Lactobacilli Modifies the Murine Microbiome and Reduces Citrobacter Induced Colitis

et al. 2020

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Significant evidence supports a relationship between the gut microbiome, inflammation, host response, and health, including the finding that a number of disorders are associated with disruption of the microbiome. In these disorders, a number of dietary interventions (including prebiotics, live probiotics, or heat-killed microbes) have been proposed to be curative or preventative agents. The use of heat-killed microbes has a number of benefits over living organisms, including reduced infection risk in vulnerable individuals, extended shelf life and the potential for use in combination with antimicrobial agents. We previously reported that murine chow supplemented with 5% ADR-159, a heat-treated fermentate generated by two Lactobacillus strains, altered both behavior and the microbiome of male mice. Now we show that ADR-159 fed female mice also display a similar microbiome shift as determined by 16S rDNA analysis. In particular, we observed a reduction of levels of Turicibacter and Clostridium sensu stricto. These subtle changes in the bacterial component of the microbiome were mirrored by changes in the virome. Extended consumption of the ADR-159 diet had no negative effect on general health and lipocalin 2 levels (LCN2; a proxy for inflammation), but we observed increased IL-17f and decreased IL-12α expression in the colon and decreased short chain fatty acid levels in the ADR-159 fed animals. Four weeks into the diet, half of the animals were dosed with Citrobacter to determine the effect of ADR-159 on infection and on pathogen induced colitis. Overall, our results suggest that while the ADR-159 diet does not prevent Citrobacter infection, it had an effect on Citrobacter-induced inflammation. In contrast to animals fed standard chow, ADR-159 fed animals did not show a reduction of small intestine length and increase of colon crypt depth, which occurred in control mice. These microbiological, histological, and immunological results provide evidence to support the impact of heat-treated microorganisms and their metabolites on the murine microbiome and health.

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Section: Effect Of Adr-159 On Citrobacter-induced Colitismentioning

confidence: 99%

Oral Administration of Heat-Treated Lactobacilli Modifies the Murine Microbiome and Reduces Citrobacter Induced Colitis

et al. 2020

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“…Besides, T cells 7 and B cells population 8, tumor-associated macrophages 9 and infiltrating dendritic cells 10 are also related with IL-35 upregulation. IL-35 is not a constitutive tissue product 11 and only expressed in certain tissues after pro-inflammatory activation by various stimuli such as tumor necrosis factor-α (TNF-α), interferon-c (IFN-c), and IL-1β 12. It was originally named in 13th International Congress of Immunology and currently grabs a significant attention of scientific community 13.…”

Section: Introductionmentioning

confidence: 99%

Interleukin-35 as an Emerging Player in Tumor Microenvironment

Xue¹,

Yan²,

Kan³

2019

J. Cancer

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IL-35 is the newest member of IL-12 family. A dimeric protein consisting of two separate subunits has manifested suppressive actions on immune system, which is counterproductive in the context of cancers. Various reports have confirmed its inhibitory role on immune system which is carried out via formation of IL-35-producing regulatory T cells (iTr35), increased Treg development and suppressive Th17 cells growth. Although last decade has seen a great deal of scientific interest on this subject, the exact role, precise signal transduction and elaborative functions of IL-35 in tumor microenvironment (TME) remained elusive. Search for anti-IL-35 therapies have exhibited limited success in animal models. Contrarily, few studies have denied the idea that IL-35 plays a role in cancer. The purpose of this review is to analyze the reported scientific data on continuous symphony of IL-35 in cancers since the inception of former.

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“…In addition, the anti-inflammatory activity of IL-35 is conducted by enhancing regulatory B cells, and inhibiting macrophages and effector T cells [40]. Consistently, diminished IL-35 is primarily associated with chronic infection [41] and type 1 diabetes mellitus [42]. Also, a low concentration of IL-35 was influenced in the progression of peptic ulcer of patients infected with H. pylori [43].…”

Section: Discussionmentioning

confidence: 96%

Effect of antidiabetic therapy on TNF-α, IL-18, IL-23 and IL-35 levels in T2DM patients with coincidental Helicobacter pylori infection

Abdel-Moneim

El‐Twab

Nabil

et al. 2020

Journal of Taibah University for Science

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This study aimed to evaluate the relationship between tumour-necrosis factor-alpha (TNF-α), interleukin (IL)-18, IL-23, IL-35 and Heilcobacter (H) pylori infection with T2DM. A total of 25 healthy subjects and 102 confirmed T2DM patients were enrolled in this study. Diabetic patients were subdivided into six groups according to antidiabetic therapy. Diabetic non-treated patients exhibited a significant elevation in H. Pylori-Ig-G, TNF-α, IL-18, and IL-23 levels, but a noticeable decrease in IL-35 expression was observed compared to healthy controls. Antidiabetic therapy induced a significant decrease in the level of glycosylated hemoglobin (HbA1c), TNF-α, IL-18 and IL-23, while IL-35 expression was upregulated compared to diabetic controls. The results exhibited a positive correlation between H. pylori and HbA1c%, TNF-α, IL-18, and IL-23 values, and also between HbA1c% and TNF-α, IL-18 and IL-23 levels. Therefore, antidiabetic therapy decreases significantly the hyperglycemic state and circulating level of inflammatory cytokines which reflects their potential anti-inflammatory effects.

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The Role, Involvement and Function(s) of Interleukin-35 and Interleukin-37 in Disease Pathogenesis

Cited by 32 publications

References 109 publications

Oral Administration of Heat-Treated Lactobacilli Modifies the Murine Microbiome and Reduces Citrobacter Induced Colitis

Oral Administration of Heat-Treated Lactobacilli Modifies the Murine Microbiome and Reduces Citrobacter Induced Colitis

Interleukin-35 as an Emerging Player in Tumor Microenvironment

Effect of antidiabetic therapy on TNF-α, IL-18, IL-23 and IL-35 levels in T2DM patients with coincidental Helicobacter pylori infection

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