The Road to Unified Chromatography: The Importance of Phase Behavior Knowledge in Supercritical Fluid Chromatography and Related Techniques, and a Look at Unification

Chester, T. L.

doi:10.1006/mchj.1998.1638

Cited by 16 publications

(2 citation statements)

References 13 publications

(12 reference statements)

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“…In practice modifier concentrations are kept below 50%. One reason is that using higher concentrations of modifier might alter the critical point of the mixture with carbon dioxide too much and a situation might occur in which the mobile phases no longer exists in a sub-or supercritical state but in a liquid-vapor state, that no longer displays the supercritical-fluid characteristics [73][74][75]. A second reason is that small concentrations of polar modifiers already can dramatically increase the solvent strength [35,73].…”

Section: Mobile Phasementioning

confidence: 99%

Supercritical fluid chromatography for the enantioseparation of pharmaceuticals

Klerck

Mangelings

Heyden

2012

Journal of Pharmaceutical and Biomedical Analysis

168

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Section: Mobile Phasementioning

confidence: 99%

Supercritical fluid chromatography for the enantioseparation of pharmaceuticals

Klerck

Mangelings

Heyden

2012

Journal of Pharmaceutical and Biomedical Analysis

168

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“…There may even be situations in which a gradient involving the addition of a modifier to the CO 2 mobile phase changes the conditions from supercritical to near critical conditions during the separation process. This is possible because of the continuum of properties when moving from the sub‐ to supercritical region .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of an amide‐based stationary phase for supercritical fluid chromatography

Borges-Muñoz

Colón

2016

J of Separation Science

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A relatively new stationary phase containing a polar group embedded in a hydrophobic backbone (i.e., ACE® C18-amide) was evaluated for use in supercritical fluid chromatography. The amide-based column was compared with columns packed with bare silica, C18 silica, and a terminal-amide silica phase. The system was held at supercritical pressure and temperature with a mobile phase composition of CO2 and methanol as cosolvent. The linear solvation energy relationship model was used to evaluate the behavior of these stationary phases, relating the retention factor of selected probes to specific chromatographic interactions. A five-component test mixture, consisting of a group of drug-like molecules was separated isocratically. The results show that the C18-amide stationary phase provided a combination of interactions contributing to the retention of the probe compounds. The hydrophobic interactions are favorable; however, the electron donating ability of the embedded amide group shows a large positive interaction. Under the chromatographic conditions used, the C18-amide column was able to provide baseline resolution of all the drug-like probe compounds in a text mixture, while the other columns tested did not.

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Historical Development of SFC

2019

Modern Supercritical Fluid Chromatography

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The Road to Unified Chromatography: The Importance of Phase Behavior Knowledge in Supercritical Fluid Chromatography and Related Techniques, and a Look at Unification

Cited by 16 publications

References 13 publications

Supercritical fluid chromatography for the enantioseparation of pharmaceuticals

Supercritical fluid chromatography for the enantioseparation of pharmaceuticals

Evaluation of an amide‐based stationary phase for supercritical fluid chromatography

Historical Development of SFC

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