The risk of Stevens‐Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs: Comment on data sparsity

Safiri, Saeid; Ashrafi‐Asgarabad, Ahad

doi:10.1111/epi.14024

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Care is directed at signs and complications (supportive care). It is assumed that patient having SJS/TEN caused by drugs must quit the drug as soon as possible (Safiri and Ashrafi-Asgarabad, 2018).…”

Section: Treatmentmentioning

confidence: 99%

Stevens - Johnson Syndrome: A Short Review

Ashok¹,

Babu²,

Sumathi³

et al. 2021

IJZI

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The syndrome of Stevens-Johnson (SJS) and toxic epidermal necrolysis (TEN) are serious, mostly medicated, cutaneous adverse reactions, normally linked to a high degree of morbidity and mortality. Recently, the SJS/TEN management guidance, the Indian guidelines and the United Kingdom directives have been written in details. However, there is no agreement on SJS/TEN management. In this paper, we would like to conceptualise SJS/TEN system in order of Indian schedule. It has been found useful to discontinue all drugs early, take help steps (hydration, electrolytes, and skin care denuded), corticosteroids, and cyclosporine. Oral provocation tests are only available to those receiving full remission that are strictly attentive during hospitalisation. As there is no majority, care on an individual basis should be personalised.

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Section: Treatmentmentioning

confidence: 99%

Stevens - Johnson Syndrome: A Short Review

Ashok¹,

Babu²,

Sumathi³

et al. 2021

IJZI

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“…In their study of Stevens‐Johnson syndrome and toxic epidermal necrolysis and its association with antiepileptic drug use, Frey et al have used exact methods to estimate the ORs and CIs “where there were no exposed cases/controls.” Even so, the resulting ORs are large and the CIs are very wide (including infinite values). Therefore, it is possible that in this case, penalization would have been the preferred method to stabilize the estimates, as suggested by Safiri and Ahran‐Asgarabad . The response by Frey et al .…”

mentioning

confidence: 99%

Sparse data and use of logistic regression

Siddarth

2018

Epilepsia

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Fuchs Syndrome: Uncommon or Under Diagnosed?

Singh,

Arora,

Saipangallu

et al. 2024

Journal of Clinical Infectious Disease Society

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Stevens–Johnson syndrome (SJS) with mucosal involvement without any skin lesions has been described as Fuchs syndrome. This pure mucosal variant of SJS has been described more frequently in children and adolescents than adults. Most of the cases are triggered by infections commonly due to herpes simplex and Mycoplasma pneumoniae. Mucosal lesions predominate; however, ocular and genital lesions are often present. In this case report, we present a successfully managed rare case of a 25-year-old male who was diagnosed with M. pneumoniae-upper respiratory tract infection associated with Fuchs syndrome. In the absence of a high index of suspicion, the correct diagnosis is often missed, and appropriate therapy is delayed.

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The risk of Stevens‐Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs: Comment on data sparsity

Cited by 3 publications

References 6 publications

Stevens - Johnson Syndrome: A Short Review

Stevens - Johnson Syndrome: A Short Review

Sparse data and use of logistic regression

Fuchs Syndrome: Uncommon or Under Diagnosed?

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