The Risk of Glaucoma in Pseudoexfoliation Syndrome

Jeng, Samuel M.; Karger, Randy A.; Hodge, David O.; Burke, J. P.; Johnson, Douglas H.; Good, Margaret S.

doi:10.1097/01.ijg.0000243470.13343.8b

Cited by 84 publications

(52 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a recent study, XFS was found to have a 15-year risk of conversion to XFG by nearly 60%. 9 Estimates for XFS prevalence in individuals over age 65 vary from 0% in the Inuit population to 7% in the United States to 21% in Greek, Latvian, Russian, Icelandic, Scandinavian and Saudi Arabian populations, which may be due to different race background. [10][11][12] Several studies suggest that genetic factors may contribute to its pathogenesis, including twins, 13 Recently, one SNP rs2165241 in intron1 and two SNPs rs1048661 (R141L) and rs3825942 (G153D) in exon1 of the gene LOXL1 were found to be associated with the XFG and XFS phenotype in Icelandic and Swedish patients.…”

Section: Introductionmentioning

confidence: 99%

Genetic association of LOXL1 gene variants and exfoliation glaucoma in a Utah cohort

Yang

Zabriskie²,

Hau³

et al. 2008

Cell Cycle

View full text Add to dashboard Cite

Exfoliation glaucoma (XFG) is the commonest identifiablecause of secondary open-angle glaucoma worldwide, characterized by the deposition of fibrillar proteins in the anterior segment of the eye. We investigated LOXL1 gene variants previously identified to confer susceptibility to XFG in a Utah Caucasian cohort. After a standard eye examination protocol we genotyped SNPs rs2165241 and rs3825942 in 62 XFG or exfoliation syndrome (XFS) patients and 170 normal controls. Genotype frequency distribution, odds ratios (ORs) and population attributable risks were calculated for the risk alleles. The SNP rs2165241 was significantly associated with XFG and XFS (p = 4.13 x 10 -9 for an additive model, OR het = 4.42 (2.30 -8.50), OR hom = 34.19 (4.48 -261.00); T allele: 83.1% in cases versus 52.4% in controls). Significant association was also found for rs3825942: (p = 1.89 x 10 -6 ). Our findings confirm genetic association of LOXL1 with XFG and XFS and implicate a potential role of cross linking of elastin in the pathogenesis of XFG. This information will potentially guide glaucoma monitoring efforts by targeting individuals whose genetic profiles put them at higher risk for XFG.

show abstract

Section: Introductionmentioning

confidence: 99%

Genetic association of LOXL1 gene variants and exfoliation glaucoma in a Utah cohort

Yang

Zabriskie²,

Hau³

et al. 2008

Cell Cycle

View full text Add to dashboard Cite

show abstract

“…Prognoza je lošija kod pseudoeksfolijativnog (kapsularnog) glaukoma nego kod primarnog glaukoma otvorenog ugla. Povišen intraokularni pritisak (IOP) u pseudoeksfolijativnim očima dovodi do glaukomatoznih ošte-ćenja u toku dužeg vremena i to u većem stepenu nego u očima bez pseudoeksfolijacija (14).…”

Section: Ključne Rečiunclassified

Pseudoexfoliation glaucoma: Always actual problem in ophthalmology

Vasović¹,

Markovic²

2018

Medicinski podmladak

View full text Add to dashboard Cite

Introduction: Pseudoexfoliation (PEX) syndrome is not only an ocular disease but also a general disorder that involves the abnormal production and disposal of extracellular matrix material in intra-and extraocular tissues. Intraocular pressure (IOP) of the pseudoexfoliative eyes is higher than IOP of the nonpseudoexfoliative eyes which leads to more severe eye damage during longer period of time. Glaucoma in the pseudoexfoliation syndrome has been shown to have a more serious clinical course than in primary open-angle glaucoma. Aim: The aim of our study was to determine the presence and frequency of capsular glaucoma compared to other types of glaucoma among patients examined in one month period and in total number of glaucoma operated patients during last year. Materials and methods: Our study involved 105 patients examined and diagnosed in November 2016 and 346 glaucoma patients operated between January and October 2016 at Clinic for eye diseases, Clinical Centre of Serbia. Methods used in examination and monitoring of patients were: biomicroscopy, applanation tonometry, computerized perimetry, ophthalmoscopy, gonioscopy and Heidelberg Retinal Tomography II. Results: Although the frequency of capsular glaucoma in our sample was more common in women 14 (13.4 %) compared to men 11 (10.4 %), statistically significant difference related to sex was not observed (p = 0.352). Binocular expression was 3.7 times more often than monocular in women and 1.7 times in men. Among glaucoma operated patients, capsular glaucoma was found in 94 (27.2 %) cases, which leads to conclusion that every fourth patient operated last year had this type of glaucoma. Conclusion: Based on the results of our study it can be concluded that capsular glaucoma, as the most important ocular manifestation of PEX syndrome, shows high frequency in our population. Careful clinical examination should be performed in patients over the age of 50 due to the importance of early recognition and appropriate management of pseudoexfoliative material in the eye.

show abstract

“…27 In a community-based study, similar results were observed with a third of patients converting to bilateral PXFS in 15 years. 28 In the early manifest glaucoma trial, 55% of the patients with PXFS developed glaucoma after a mean observation period of 8.7 years. 29 In other studies, a third of the eyes with PEX material developed glaucoma within 10 years, 27 while an even higher rate of 44% required treatment for glaucoma after 15 years of followup.…”

Section: Evolution Of Pxfg From Pxfsmentioning

confidence: 99%

“…29 In other studies, a third of the eyes with PEX material developed glaucoma within 10 years, 27 while an even higher rate of 44% required treatment for glaucoma after 15 years of followup. 28 The risk factors for conversion to PXFG include the presence of PEX material (within ocular tissue and bilateral ocular involvement), ocular hypertension, 29 decreased pupillary dilatation 27 and the presence of pigment on the angle structures. 30 The amount of pigment present in the iridocorneal angle appears to correlate more closely with the severity and development of PXFG than the amount of PEX material on the lens capsule.…”

Section: Evolution Of Pxfg From Pxfsmentioning

confidence: 99%

Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

M¹,

Gupta²

2017

jemds

View full text Add to dashboard Cite

BACKGROUNDPseudoexfoliation syndrome is a systemic disorder characterised by the deposition of white dandruff-like material within the anterior segment of the eye and other organs such as the heart, lungs and kidneys. The deposition of this material in the trabecular meshwork can result in aqueous flow obstruction, raised intraocular pressure and glaucoma. In fact, pseudoexfoliation glaucoma is the most common form of secondary open-angle glaucoma. In contrast to primary open-angle glaucoma, this disease runs a more aggressive clinical course with high intraocular pressure at onset, faster rates of progression, poor response to medical therapy and increased need for surgical intervention.

show abstract

The Risk of Glaucoma in Pseudoexfoliation Syndrome

Abstract: In a geographically defined population of PEX patients, 16% required treatment upon presentation. Of the remaining PEX patients, 44% received therapy over the next 15 years.

Cited by 84 publications

References 23 publications

Genetic association of LOXL1 gene variants and exfoliation glaucoma in a Utah cohort

Genetic association of LOXL1 gene variants and exfoliation glaucoma in a Utah cohort

Pseudoexfoliation glaucoma: Always actual problem in ophthalmology

Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Contact Info

Product

Resources

About