1989
DOI: 10.1016/s0161-6420(89)32738-2
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The Risk of Enucieatlon after Proton Beam Irradiation of Uveal Melanoma

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Cited by 104 publications
(45 citation statements)
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“…10 Adverse effects of proton beam therapy include radiation retinopathy and papillopathy, 11 loss of vision, 10,12 cataract, 13,14 and, infrequently, enucleation. 15 Factors positively associated with an increased risk of vision loss and radiation vasculopathy, in particular, include tumor height and proximity to the optic disc or fovea.…”
mentioning
confidence: 99%
“…10 Adverse effects of proton beam therapy include radiation retinopathy and papillopathy, 11 loss of vision, 10,12 cataract, 13,14 and, infrequently, enucleation. 15 Factors positively associated with an increased risk of vision loss and radiation vasculopathy, in particular, include tumor height and proximity to the optic disc or fovea.…”
mentioning
confidence: 99%
“…Helium ion beams had been used in Lawrence Berkeley Laboratory for choroidal melanomas, the actuarial 5-and 10-year local control was 96% (Linstadt et al 1990). Proton beam with fractionated schedule was used for choroidal melanomas with Harvard Cyclotron, 96.3% of local control was reported (Egan et al 1989). The results are compatible with enucleation.…”
mentioning
confidence: 71%
“…Both radioactive plaque therapy and charge particle therapy appear to be equivalent to enucleation in terms of overall survival, and have the obvious advantages of retention of the eye and preservation of useful vision in some cases (Char 1989;Egan et al 1989;Linstadt et al 1988). The principle of these approaches is to deliver a precision high dose to cover the tumor area without affecting the normal eye tissues.…”
Section: Discussionmentioning
confidence: 99%
“…Persistent retinal detachment is untreatable, and the risk of neovascular glaucoma increases from approximately 3 to 35% [100]. Large tumor size is also associated with an increased risk of local tumor recurrence and enucleation [10,79]. On one hand posterior tumor location close to the optic disc or fovea (< 2 disc diameters) increases the risk of radiation-induced optic neuropathy and/or maculopathy as well after as plaque treatment after external beam radiotherapy (53 in 3).…”
Section: Choroidal Tumorsmentioning
confidence: 99%