The risk of cutaneous melanoma in melanocytic nevi

Fernandes, Nurimar Conceição

doi:10.1590/s0365-05962013000200030

Cited by 7 publications

(5 citation statements)

References 10 publications

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“…We observed frequent histologic regression in PVM ($25%), and this associated with improved DSS (but not OS). Precursor melanocytic nevi have been identified in association with a varying proportion of PCMs (76)(77)(78)(79), and these tend to be thinner and are associated with a slightly better prognosis than de novo melanomas (76,80). In contrast, PVMs only rarely arise in association with a precursor melanocytic nevus (refs.…”

Section: Discussionmentioning

confidence: 99%

Tumor Thickness and Mitotic Rate Robustly Predict Melanoma-Specific Survival in Patients with Primary Vulvar Melanoma: A Retrospective Review of 100 Cases

Nagarajan

Curry

Ning

et al. 2017

Clinical Cancer Research

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Primary vulvar melanoma (PVM) is the second most common vulvar malignancy. Despite their distinct anatomic site and unique molecular-genetic alterations, PVMs are staged according to the American Joint Committee on Cancer (AJCC) guidelines for primary cutaneous melanomas (PCM). However, whether parameters derived for PCM also apply to PVM remain a critical yet largely unexplored clinical question. The objective of this study was to determine the parameters predictive of survival in PVM. We retrospectively reviewed 100 patients with PVM and determined associations between clinical and histopathologic parameters and disease-specific survival (DSS) and overall survival (OS). Univariate Cox regression analysis demonstrated older age (>56 years), greater tumor thickness, higher dermal mitotic rate, ulceration, lymphovascular invasion, perineural invasion, microscopic satellitosis, and absence of precursor nevus associated with decreased OS. Furthermore, age, midline, and/or multifocal involvement, greater tumor thickness, higher dermal mitotic rate, ulceration, lack of regression, lymphovascular invasion, perineural invasion, and microscopic satellitosis associated with decreased DSS. Multivariate analysis demonstrated tumor thickness, dermal mitotic rate, lymphovascular invasion, microscopic satellitosis, and absence of precursor nevus independently predicted shorter OS. Only tumor thickness and increased dermal mitotic rate (≥2/mm) independently predicted reduced DSS. In comparison with the AJCC T-category, a novel, bivariate T-category based only on tumor thickness and dermal mitotic rate robustly predicted OS and DSS in our patient cohort. In the largest single institutional study of PVM, we demonstrate a combination of tumor thickness and mitotic rate comprise a simple but robust T-category to direct staging and prognosis. .

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Section: Discussionmentioning

confidence: 99%

Tumor Thickness and Mitotic Rate Robustly Predict Melanoma-Specific Survival in Patients with Primary Vulvar Melanoma: A Retrospective Review of 100 Cases

Nagarajan

Curry

Ning

et al. 2017

Clinical Cancer Research

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“…10 Only one case of malignant transformation of kissing nevus of the penis has been reported. 6 Therefore patients with kissing nevus should be given a close follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…Although rare, a malignant transformation of a kissing nevus might take place both in the eyelids and the penis. 10 Only one case of malignant transformation of kissing nevus of the penis has been reported. 6 Therefore patients with kissing nevus should be given a close follow-up.…”

Section: Discussionmentioning

confidence: 99%

Kissing nevus of the penis. Report of two cases and review of the literature

Wang

Zhou

Qiao

2014

An. Bras. Dermatol.

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“…Мно-гочисленные онкоэпидемиологические исследования указывают на значительную территориальную вариабель-ность заболеваемости МК. Приоритетные направления ранней диагностики и профилактики МК среди населе-ния должны основываться на региональных эпидемиоло-гических особенностях и закономерностях распростра-нения МК как среди всей популяции, так и у отдельных групп населения, проживающих на определенных терри-ториях [5][6][7].…”

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Monitoring the epidemiological indicators of the incidence of cutaneous melanoma and the possibility of enhancing the effectiveness of its early diagnosis in the Republic of Crimea

Кузнецова¹,

Pritulo²,

Прохоров³

et al. 2016

Onkol. Z. im. P.A. Gercena

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Мониторинг эпидемиологических показателей заболеваемости меланомой кожи и возможности повышения эффективности ее ранней диагностики в Республике Крым о.А. Притуло, д.в. ПроХоров, М.ю. КуЗнецовА Медицинская академия им. С.и. Георгиевского ФГАоу во «КФу им. в.и. вернадского», Симферополь, республика Крым Приведены эпидемиологические показатели заболеваемости и смертности от меланомы кожи в республике Крым. Анали-зируются причины роста заболеваемости, пути совершенствования ранней диагностики и профилактики меланомы кожи. дана оценка реализации онкологической программы, которая направлена на качественное преобразование системы ока-зания первичной и специализированной медицинской помощи, усиление роли и повышение ответственности первичного медико-санитарного звена в раннем выявлении злокачественных новообразований, повышение онкологической насторо-женности и профессионализма медицинских работников в области клинической онкологии. разработка и внедрение про-филактических и скрининговых программ регионального уровня позволяет выявлять больных до стадии манифестации заболевания, существенно повышая шансы на эффективность специфического лечения и благоприятный прогноз. The paper presents the epidemiological indicators of cutaneous melanoma mortality and morbidity in the republic of crimea. It analyzes the reasons for increasing mortality rates and the ways of improving the early diagnosis and prevention of cutaneous melanoma. The implementation of the cancer program aimed to qualitatively transform the primary and specialized healthcare system and to increase the role and responsibility of primary health care in the early detection of malignant tumors and the cancer alertness and professional competence of health workers in clinical oncology is assessed. The elaboration and introduction of prevention and screening programs at the regional level allow identification of patients before the manifestation of the disease, by substantially increasing their chances for the efficiency of specific treatment and for a favorable prognosis.

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The risk of cutaneous melanoma in melanocytic nevi

Cited by 7 publications

References 10 publications

Tumor Thickness and Mitotic Rate Robustly Predict Melanoma-Specific Survival in Patients with Primary Vulvar Melanoma: A Retrospective Review of 100 Cases

Tumor Thickness and Mitotic Rate Robustly Predict Melanoma-Specific Survival in Patients with Primary Vulvar Melanoma: A Retrospective Review of 100 Cases

Kissing nevus of the penis. Report of two cases and review of the literature

Monitoring the epidemiological indicators of the incidence of cutaneous melanoma and the possibility of enhancing the effectiveness of its early diagnosis in the Republic of Crimea

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