The risk factors of adverse pregnancy outcome for pre-pregnancy couples in Hunan, China

Xie, Da; Xiang, Yueyun; Wang, Aihua; Xiong, Lili; Kong, Fanrong; Liu, Zhiyu; Wang, Hua

doi:10.1097/md.0000000000023094

Cited by 7 publications

(6 citation statements)

References 17 publications

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“…Only 42 neonates with low birth weight were delivered in our study and there was no significant difference between the two groups. After adjustment using multivariable logistic regression, older age, especially older than 35 years, was also seen as an important risk factor of adverse pregnant outcomes, which is similar to the results of a previous study (22). There are some limitations in our study.…”

Section: Discussionsupporting

confidence: 85%

Pathogen profile and risk factors of aerobic vaginitis in pregnant women: a retrospective cohort study

Li¹,

Yi²,

Chen³

2021

Ann Palliat Med

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Background: Vaginitis is one of the most common gynecological diseases in women and may severely affect the quality of life in patients. However, very few studies have investigated aerobic vaginitis (AV) in pregnant women, and our study was designed to identify the pathogen profile, clinical importance, and risk factors of AV in pregnancy.Methods: This was a retrospective cohort study enrolling 685 women who attended our hospital between July 2018 and June 2020. Based on the incidence of AV, enrolled women were divided into an AV group and healthy control group, and demographic and clinical characteristics were retrospectively collected by two independent investigators. Some pathogens of AV were tested using quantitative real-time polymerase chain reaction for higher accuracy. Pregnancy outcomes were also retrospectively collected. Univariable and multivariable logistic regression analysis was used to determine the risk factors of AV incidence and adverse pregnant outcomes.Results: Enrolled women were divided into an AV group of 182 women and healthy control group of 503 women. The proportions of women with a history of cesarean delivery and history of vaginal infection differed between the groups (P=0.002 and <0.001, respectively). The mean gestational week at diagnosis of AV was 22.3±8.6 weeks, and the most common pathogen of AV was Escherichia coli (28.6%). After adjustment using multivariable logistic regression, a history of vaginal infection acted as an important risk factor of AV incidence, while a history of cesarean delivery, college education or above, and being employed could protect pregnant women from AV. In addition, the incidences of preterm birth, premature rupture of membranes, neonatal jaundice, and neonatal infection were much higher in the AV group than in the control group, showing significant difference (P<0.001, <0.001, =0.007, and =0.025). After adjustment using multivariable logistic regression, the incidence of AV and older age were important risk factors of premature rupture of membranes and neonatal infection.Conclusions: Compared with healthy pregnant women, the presence of AV may increase the incidence of adverse outcomes. More attention should be paid to pregnant women with a history of vaginal infection.

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Section: Discussionsupporting

confidence: 85%

Pathogen profile and risk factors of aerobic vaginitis in pregnant women: a retrospective cohort study

Li¹,

Yi²,

Chen³

2021

Ann Palliat Med

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“…The most pronounced decreases in trends in ASR of prevalence, DALYs and death were observed for maternal hemorrhage. The declined trends might be due to the general economic growth, a reduced fertility rate [3] , and the Free Pre-pregnancy Health Check (FPHC) surveillance program initiated by the Health Ministry of China in 2010 [16] . Besides, for reducing the maternal mortality, China initiated the national Five Strategies for Maternal and Newborn Safety (FSMNS), which is composed of five parts: (1) pregnancy risk screening and assessment strategy, (2) case- by- case management strategy for high- risk pregnancies, (3) referral and treatment strategy for critically ill pregnant women and newborns, (4) reporting strategy for maternal deaths (and 5) accountability strategy [17] .…”

Section: Discussionmentioning

confidence: 99%

Burden of maternal disorders in China from 1990 to 2019: Analysis of the Global Burden of Disease Study 2019

Han

Liu

Yin

et al. 2021

The Lancet Regional Health - Western Pacific

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Background Efforts to quantify the burden of maternal disorders at the national and provincial levels are valuable for resource allocation and for development and adoption of public health policies. Methods Following the methods of the Global Burden of Diseases, Injuries, and Risk Factors Study 2019, the prevalence of maternal disorders and the resulting disability-adjusted life years (DALYs), years lived with disability(YLD), deaths, and years of life lost (YLL) at the national and provincial levels in China were examined for the 1990–2019 period. Estimated annual percentage changes (EAPCs) were calculated to estimate the trends of age-standardized rate (ASR) of prevalence, DALYs, death, and YLD due to maternal disorders and its main subcategories from 1990 to 2019. Findings In 2019, China had an estimated 0.85 million cases of maternal disorders (95% uncertainty interval: 0.65–1.08 million), with a 73% decline in absolute numbers from 1990 to 2019. The ASR of prevalence, DALYs and death for overall maternal disorders showed decreasing trends in China from 1990 to 2019 with the EAPCs being −3.25(95% confidence interval [CI] = −3.86 to −2.64), −8.07 (95% CI= −9.14 to −6.98), and −7.04 (95% CI= −7.99 to −6.07), respectively. The most pronounced decreases in trends in ASR of prevalence, DALYs and death were observed for maternal hemorrhage. Shandong, Hong Kong, Macao showed no significant trends in ASR of prevalence. Notably, the trends in ASR of prevalence due to maternal hypertensive disorders had been stable in China and most provinces. The trends in ASR of DALYs and death decreased the most in Jiangxi province. Interpretation The disease burden of prevalence, DALYs and death for overall maternal disorders decreased significantly in China from 1990 to 2019, however, the trends in ASR of prevalence due to maternal hypertensive disorders had been stable in China and most provinces. Funding The study is supported by grants from the Innovative Talent Support Plan of the Medical and Health Technology Project in Zhejiang Province (2021422878), Ningbo Science and Technology Project (202002N3152), Ningbo Health Branding Subject Fund (PPXK2018–02), Sanming Project of Medicine in Shen-zhen (SZSM201803080).

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“…[ 1 ] On the other hand, the prevalence rate in China is about 56 per 1000 live births. [ 2 ] Previously, we have reported that a total of 17753 in 925413 surveilled perinatal infants suffer BDs between 2005 and 2014 in Hunan province, China. [ 3 ] Our further study showed that the heredity and advanced maternal age (>35 years) are the major factors bringing BDs, and the other factors, including drinking, radiation, smoking, etc, also lead to BDs.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…[3] Our further study showed that the heredity and advanced maternal age (>35 years) are the major factors bringing BDs, and the other factors, including drinking, radiation, smoking, etc, also lead to BDs. [2] Except those factors, medication use during pregnancy is an important and complicated factor involved in BD occurrence. [4] To help clinicians and pregnant women improve the safety of the medical prescription in clinic, some official classification systems were established to describe the risks of medications based on clinical and/or nonclinical evidences, such as the United States Food and Drug Administration (FDA) pregnancy risk category (categories A, B, C, D, and X), the Swedish classification system (Farmaceutiska Spesialiteter i Sverige, categories A, B, C, D), and the Australian classification system (categories A, B1, B2, B3, C, D, and X).…”

Section: Introductionmentioning

confidence: 99%

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Medication use during pregnancy and birth defects in Hunan province, China, during 2016–2019: A cross-sectional study

et al. 2022

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Safety of drug use during pregnancy attracts attentions from clinicians, pregnant woman, and even the total society. However, the studies about medication use during pregnancy and the followed birth defects (BDs) are rare in Chinese. To study condition about medication use during pregnancy and the followed BDs in Hunan province of China, here a cross-sectional study was carried out. All women using medication during pregnancy and delivering fetuses with BDs in Hunan province, China, during 2016 to 2019 were employed in this study. The descriptive analysis was carried out with Excel 2010, and the data analyses were performed by using Chi-Squared test in SPSS 16.0. After filtering, a total of 752 cases were included. In these fetuses, the males are more than females (P < .05). The severe BDs, leading to death or uncorrectable lifelong deformity, were observed for 346 times, and the other (minor) BDs were observed for 593 times. The most used drugs, categorized into pregnancy C, D, or X degrees by food and drug administration (FDA) or pharmaceutical manufacturers, mainly included anti-hyperthyroidism drugs, anti-epilepsy drugs, preventing miscarriage drugs, etc. This population-based data highlight the potential high risks for BDs from the aspect of drug use during pregnancy in Hunan province of China, and drugs with more safety, less kinds, and lower doses should be the better choice for pregnant women.

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The risk factors of adverse pregnancy outcome for pre-pregnancy couples in Hunan, China

Cited by 7 publications

References 17 publications

Pathogen profile and risk factors of aerobic vaginitis in pregnant women: a retrospective cohort study

Pathogen profile and risk factors of aerobic vaginitis in pregnant women: a retrospective cohort study

Burden of maternal disorders in China from 1990 to 2019: Analysis of the Global Burden of Disease Study 2019

Medication use during pregnancy and birth defects in Hunan province, China, during 2016–2019: A cross-sectional study

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