Medication use during pregnancy and birth defects in Hunan province, China, during 2016–2019: A cross-sectional study

Zou, Wei; Xie, Shuting; Liang, Changbiao; Xie, Da; Fang, Junqun; Ouyang, Bo; Sun, Li; Wang, Hua

doi:10.1097/md.0000000000030907

Cited by 3 publications

(1 citation statement)

References 56 publications

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“…In tandem with this, our review also revealed that the intake of both prescribed and unprescribed drugs including herbal medication during the early onset of pregnancy was associated with NTDs. This finding was also supported in studies conducted elsewhere 34 35 131. In line with this, in Ethiopia, a significant number of pregnant mothers use herbal medication to alleviate symptoms, during the first trimester of pregnancy, shorten the duration of labour and reduce labour pain 132–134.…”

Section: Discussionmentioning

confidence: 54%

Birth prevalence and risk factors of neural tube defects in Ethiopia: a systematic review and meta-analysis

Tesfay,

Hailu,

Habtetsion

et al. 2023

BMJ Open

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ObjectiveThis study aims to estimate the prevalence of neural tube defects (NTDs) and to identify potential risk factors in the Ethiopian context.Study designSystematic review and meta-analysis.Study participantsA total of 611 064 participants were included in the review obtained from 42 studies.MethodsPubMed (Medline), Embase and Cochrane Library databases in combination with other potential sources of literature were systematically searched, whereby studies conducted between January 2010 and December 2022 were targeted in the review process. All observational studies were included and heterogeneity between studies was verified using Cochrane Q test statistics and I2test statistics. Small study effects were checked using Egger’s statistical test at a 5% significance level.ResultThe pooled prevalence of all NTDs per 10 000 births in Ethiopia was 71.48 (95% CI 57.80 to 86.58). The between-study heterogeneity was high (I2= 97.49%, p<0.0001). Birth prevalence of spina bifida (33.99 per 10 000) was higher than anencephaly (23.70 per 10 000), and encephalocele (4.22 per 10 000). Unbooked antenatal care (AOR 2.26, 95% CI (1.30 to 3.94)), preconception intake of folic acid (AOR 0.41, 95% CI (0.26 to 0.66)), having chronic medical illness (AOR 2.06, 95% CI (1.42 to 2.99)), drinking alcohol (AOR 2.70, 95% CI (1.89 to 3.85)), smoking cigarette (AOR 2.49, 95% CI (1.51 to 4.11)), chewing khat (AOR 3.30, 95% CI (1.88 to 5.80)), exposure to pesticides (AOR 3.87, 95% CI (2.63 to 5.71)), maternal age ≥35 (AOR 1.90, 95% CI (1.13 to 3.25)), maternal low educational status (AOR 1.60, 95% CI (1.13 to 2.24)), residing in urban areas (AOR 0.75, 95% CI (0.58 to 0.97))and family history of NTDs (AOR 2.51, 95% CI (1.36 to 4.62)) were associated with NTD cases.ConclusionThe prevalence of NTDs in Ethiopia is seven times as high as in other Western countries where prevention measures are put in place. Heredity, maternal and environmental factors are associated with a high prevalence of NTDs. Mandatory fortification of staple food with folic acid should be taken as a priority intervention to curb the burden of NTDs. To smoothen and overlook the pace of implementation of mass fortification, screening, and monitoring surveillance systems should be in place along with awareness-raising measures.PROSPERO registration numberCRD42023413490.

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Section: Discussionmentioning

confidence: 54%

Birth prevalence and risk factors of neural tube defects in Ethiopia: a systematic review and meta-analysis

Tesfay,

Hailu,

Habtetsion

et al. 2023

BMJ Open

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Knowledge, Attitude, and Practice Toward Medication Use During Pregnancy: A Hospital-Based Cross-Sectional Survey

Goruntla,

Ganzi,

Otturu

et al. 2024

J Obstet Gynecol India

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The Influence of Risk Factors on the Development of Birth Defects Among Newborns in Lviv Region (Ukraine) in 2002–2022 (Part 2)

Hnateiko,

Kitsera,

Henyk-Berezovska

et al. 2024

Proc Shevchenko Sci Soc Med Sci

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Introduction. Birth defects (BDs) are an essential public health issue in children; the identification of probable risk factors should be a priority for the healthcare system. Objectives: This study aimed to determine the probable risk factors for “model” BDs in newborns. Methods. We collected and analyzed clinical-epidemiological and medical-statistic data from the primary records of children with BDs born in 2002–2022 using the “case-control” method, filling out the registration cards in maternity hospitals of Lviv Region (Ukraine). Results. There were 1,279 healthy newborns’ cards and 1,286 cards of newborns with BDs filled out. No significant difference was found in terms of body weight, height, head circumference, and chest circumference (p>0.05) among children with BDs and the control group. The age of mothers with children affected by BD was 27.3±6.1 years and had no statistically significant difference from the age of mothers of children in the control group - 25.6±7.2 years (p>0.05). Mothers who gave birth to children with BDs used drugs in the preconception period [OR=2.46; 95% CI: 1.75; 3.44] and the first trimester of pregnancy [OR=4.76; 95% CI: 3.18; 7.14] significantly more often (p<0.05) compared to mothers in the control group. Pre-pregnancy preparations were adequately conducted by 278 (21.6%) women who gave birth to children with BDs, which was statistically different from 563 (44%) women in the control group (p<0.05) [OR=2.85; 95% CI: 2.39; 3.39]. Conclusions. More efforts are necessary to identify drug safety issues during pregnancy and to improve the current information system for clinical practice.

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Medication use during pregnancy and birth defects in Hunan province, China, during 2016–2019: A cross-sectional study

Cited by 3 publications

References 56 publications

Birth prevalence and risk factors of neural tube defects in Ethiopia: a systematic review and meta-analysis

Birth prevalence and risk factors of neural tube defects in Ethiopia: a systematic review and meta-analysis

Knowledge, Attitude, and Practice Toward Medication Use During Pregnancy: A Hospital-Based Cross-Sectional Survey

The Influence of Risk Factors on the Development of Birth Defects Among Newborns in Lviv Region (Ukraine) in 2002–2022 (Part 2)

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