The right angular gyrus controls spontaneous eyeblink rate: A combined structural MRI and TMS study

Nakano, Tamami

doi:10.1016/j.cortex.2016.12.022

Cited by 14 publications

(10 citation statements)

References 25 publications

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“…We speculated that the functional damage of proprioception might be caused by the decrease of the functional connectivity of the supramarginal gyrus caused by basal ganglia damage. The angular gyrus is related to integrating semantic information and is the neurobiological basis of conceptual combination (34). A voxel-based morphometry (VBM) analysis of stroke showed that the reduction of angular gray matter volume might result in the decrease of semantic processing ability and speech orientation sensitivity (35).…”

Section: Discussionmentioning

confidence: 99%

Alterations of Functional Connectivity in Stroke Patients With Basal Ganglia Damage and Cognitive Impairment

Yao

et al. 2020

Front. Neurol.

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Background: Stroke with basal ganglia damage (SBG) is a neurological disorder characterized by cognitive impairment. The neurobiological mechanism of cognitive impairment in stroke patients with basal ganglia damage (SBG patients) remains unclear. This study aimed to explore the underlying neurobiological mechanism of cognitive impairment in SBG patients using resting-state functional magnetic resonance imaging (rs-fMRI). Methods: The differences in functional connectivity (FC) between 14 SBG patients (average age: 61.00 ± 7.45 years) and 21 healthy controls (HC) (average age: 60.67 ± 6.95 years) were examined using voxel-mirrored homotopic connectivity (VMHC) and degree centrality (DC). Moreover, we compared the cognitive functions of SBG patients with HC using the Chinese Revised Wechsler Adult Intelligence Scale (WAIS-RC) and Wechsler Memory Scale (WMS). Results: Full-scale intelligence quotient (FIQ) (t = 2.810, p < 0.010) and memory quotient (MQ) (t = 2.920, p < 0.010) scores of SBG patients were significantly lower than those of HC. Compared with HC, significantly decreased VMHC values in the bilateral angular gyrus, supramarginal gyrus, inferior frontal gyrus, middle temporal gyrus, hippocampus, precuneus, precentral gyrus, and middle occipital gyrus and decreased DC values in the right supramarginal gyrus, bilateral angular gyrus, and right postcentral gyrus were observed in SBG patients. Moreover, the VMHC values in the angular gyrus, inferior frontal gyrus, supramarginal gyrus, and middle temporal gyrus and the DC values in the right supramarginal gyrus were significantly correlated with cognitive functions in all participants. Conclusion: Our findings may provide a neural basis for cognitive impairments in SBG patients. Furthermore, local abnormalities of functional networks and interhemispheric interaction deficits may provide new ideas and insights for understanding and treating SBG patients' cognitive impairments.

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Section: Discussionmentioning

confidence: 99%

Alterations of Functional Connectivity in Stroke Patients With Basal Ganglia Damage and Cognitive Impairment

Yao

et al. 2020

Front. Neurol.

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“…EBR was defined as the ratio between the total number of blinks in a phase and the duration of the phase in minutes. To control for the large inter-individual variability, we normalized the data by computing the ratio between the EBR collected during the tasks and the rest phases, and the respective EBR collected during the baseline for each participant [2,29].…”

Section: Eeg Recording and Preprocessingmentioning

confidence: 99%

“…Eye blinks can be produced as a reflex in response to threatening stimulation of the corneal surface, as a voluntary act or spontaneously in absence of any stimulation and volition [1]. In human adults, spontaneous eye blinks appear every 3-5 seconds, with an average eye blink rate (EBR) of ∼20 blinks per minute [2,3], although with a large inter-individual variability [1,4].…”

Section: Introductionmentioning

confidence: 99%

Eye blink rate increases as a function of cognitive load during an auditory oddball paradigm

Magliacano

Fiorenza

Estraneo

et al. 2020

Neuroscience Letters

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Previous evidence suggests that changes in spontaneous eye blink rate (EBR) in human adults might reflect the amount of attentional demand (i.e. cognitive load) during cognitive tasks. However, the actual direction of this relation is uncertain, since most studies investigated the role of cognitive load on EBR by employing visual tasks only. Here we aimed at elucidating the relationship between EBR and cognitive load in non-visual tasks.Sixteen healthy participants performed two auditory oddball tasks, i.e. passive listening to auditory tones versus active counting of target tones; each oddball task was immediately followed by a rest phase. Throughout the oddball tasks we assessed EBR and recorded the P300 on ERPs as an electrophysiological measure of attention.The results showed that participants' EBR increased during the active task compared to the respective rest phase. Amplitude and latency of the P300 too differed between passive and active tasks, but changes in EBR and P300 features were not correlated with each other.Our findings demonstrated that an increase in cognitive load is associated with an increase in EBR in cognitive tasks not involving visual attention. These findings are consistent with previous evidence suggesting shared neurobiological bases between attention and EBR. tasks [19,20] and found that EBR decreased when task difficulty

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“… ( a ) From References [ 5 , 8 , 14 , 15 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]; ( b ) (▲) from Reference [ 52 ] and (●) Reference [ 53 ]; ( c , d , f ) hydrocarbon chain order at 33.4 ° C and phase transition parameters for the lipid order (gel) to disorder (liquid crystal) phase transition of human meibum. (●) Reference [ 26 ]; (■) Reference [ 1 ]; (▲) this study and (▼) Reference [ 25 ].…”

Section: Figurementioning

confidence: 99%

Human Meibum Age, Lipid–Lipid Interactions and Lipid Saturation in Meibum from Infants

Sledge

Henry

Borchman

et al. 2017

IJMS

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Tear stability decreases with increasing age and the same signs of instability are exacerbated with dry eye. Meibum lipid compositional changes with age provide insights into the biomolecules responsible for tear film instability. Meibum was collected from 69 normal donors ranging in age from 0.6 to 68 years of age. Infrared spectroscopy was used to measure meibum lipid phase transition parameters. Nuclear magnetic resonance spectroscopy was used to measure lipid saturation. Increasing human meibum lipid hydrocarbon chain unsaturation with age was related to a decrease in hydrocarbon chain order, cooperativity, and in the phase transition temperature. The change in these parameters was most dramatic between 1 and 20 years of age. Meibum was catalytically saturated to determine the effect of saturation on meibum lipid phase transition parameters. Hydrocarbon chain saturation was directly related to lipid order, phase transition temperature, cooperativity, changes in enthalpy and entropy, and could account for the changes in the lipid phase transition parameters observed with age. Unsaturation could contribute to decreased tear film stability with age.

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The right angular gyrus controls spontaneous eyeblink rate: A combined structural MRI and TMS study

Cited by 14 publications

References 25 publications

Alterations of Functional Connectivity in Stroke Patients With Basal Ganglia Damage and Cognitive Impairment

Alterations of Functional Connectivity in Stroke Patients With Basal Ganglia Damage and Cognitive Impairment

Eye blink rate increases as a function of cognitive load during an auditory oddball paradigm

Human Meibum Age, Lipid–Lipid Interactions and Lipid Saturation in Meibum from Infants

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