Alterations of Functional Connectivity in Stroke Patients With Basal Ganglia Damage and Cognitive Impairment

Yao, Guanqun; Li, Jing; Li, Sha; Wang, Jiaojian; Cao, Xiaohua; Li, Xinrong; Cheng, Long; Chen, Huafu; Xu, Yong

doi:10.3389/fneur.2020.00980

“…Here we provide evidence that the MoCA can be used to assess cognitive impairment of patients after basal ganglia stroke, and our analysis suggests that such stroke can indeed reduce cognitive function, consistent with previous studies [ 13 – 15 ]. In addition, our analysis shows that such stroke can reduce function in multiple cognitive domains.…”

Section: Discussionsupporting

confidence: 90%

Montreal Cognitive Assessment of cognitive dysfunction after basal ganglia stroke

Ye

¹

,

Wei

²

,

Pan

³

2022

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Objective The Montreal Cognitive Assessment (MoCA) was used to evaluate cognitive dysfunction after basal ganglia stroke, and factors affecting total MoCA score were examined. Methods Data were retrospectively analyzed for 30 patients with basal ganglia intracerebral hemorrhage or basal ganglia cerebral infarction, who were admitted to The Second Affiliated Hospital of Fujian Traditional Medical University (Fujian, China) from January 2017 to March 2020. Cognitive impairment was assessed using the MoCA, and potential correlations were explored between clinicodemographic characteristics (sex, age, stroke location and etiology) and MoCA dimensions or total MoCA score. Results Univariate linear regression showed that the total MoCA score was significantly associated with sex, age, executive function, naming, attention, abstract generalization ability, memory ability, and visuospatial orientation. However, multivariate linear regression identified only executive function, naming, attention, memory ability, and visuospatial orientation as significantly associated with the total MoCA score. Conclusions We showed that the MoCA test can be used for patients with basal ganglia stroke. The total MoCA score of basal ganglia stroke was significantly associated with impairments in executive function, naming, attention, memory ability, and visuospatial orientation.

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“…Here we provide evidence that the MoCA can be used to assess cognitive impairment of patients after basal ganglia stroke, and our analysis suggests that such stroke can indeed reduce cognitive function, consistent with previous studies (13)(14)(15). In addition, our analysis shows that such stroke can reduce function in multiple cognitive domains.…”

Section: Discussionsupporting

confidence: 90%

Montreal Cognitive Assessment of cognitive dysfunction after basal ganglia stroke

Ye

¹

,

Wei

²

,

Pan

³

2022

Preprint

View full text Add to dashboard Cite

Objective The Montreal Cognitive Assessment (MoCA) was used to evaluate cognitive dysfunction after basal ganglia stroke, and factors affecting total MoCA score were examined. Methods Data were retrospectively analyzed for 30 patients with basal ganglia intracerebral hemorrhage or basal ganglia cerebral infarction, who were admitted to The Second Affiliated Hospital of Fujian Traditional Medical University (Fujian, China) from January 2017 to March 2020. Cognitive impairment was assessed using the MoCA, and potential correlations were explored between clinicodemographic characteristics (sex, age, stroke location and etiology) and MoCA dimensions or total MoCA score. Results Univariate linear regression showed that the total MoCA score was significantly associated with sex, age, executive function, naming, attention, abstract generalization ability, memory ability, and visuospatial orientation. However, multivariate linear regression identified only executive function, naming, attention, memory ability, and visuospatial orientation as significantly associated with the total MoCA score. Conclusions We showed that the MoCA test can be used for patients with basal ganglia stroke. The total MoCA score of basal ganglia stroke was significantly associated with impairments in executive function, naming, attention, memory ability, and visuospatial orientation.

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“…A previous study showed that decreased functional connectivity (FC) between hippocampal and SMG was associated with impaired working memory function in stroke patients [ 31 ]. Similar results were also found in the previous studies focusing on the patients with acute BGIS which observed the decreased degree centrality (DC) and voxel-mirrored homotopic connectivity (VMHC) values in SMG [ 32 ]. Furthermore, aphasia is a common symptom in stroke [ 33 ].…”

Section: Discussionsupporting

confidence: 90%

Frequency-Specific Changes of Amplitude of Low-Frequency Fluctuations in Patients with Acute Basal Ganglia Ischemic Stroke

Quan

¹

,

Hu

²

,

Meng

³

et al. 2022

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Objective. The purpose of this study was to investigate the characteristics of different frequency bands in the spontaneous brain activity among patients with acute basal ganglia ischemic stroke (BGIS). Methods. In the present study, thirty-four patients with acute BGIS and forty-four healthy controls were examined by resting-state functional magnetic resonance imaging (rs-fMRI) from May 2019 to December 2020. Two amplitude methods including amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) calculated in three frequency bands (conventional frequency band: 0.01-0.08 Hz; slow-5 frequency band: 0.01-0.027 Hz; and slow-4 frequency band: 0.027-0.073 Hz) were conducted to evaluate the spontaneous brain activity in patients with acute BGIS and healthy controls (HCs). Gaussian Random Field Theory (GRF, voxel p < 0.01 and cluster p < 0.05 ) correction was applied. The correlation analyses were performed between clinical scores and altered metrics values. Results. Compared to HCs, patients with acute BGIS showed decreased ALFF in the right supramarginal gyrus (SMG) in the conventional and slow-4 bands, increased fALFF in the right middle frontal gyrus (MFG) in the conventional and slow-4 bands, and increased fALFF in the bilateral caudate in the slow-5 frequency band. The fALFF value of the right caudate in the slow-5 frequency band was negatively correlated with the clinical scores. Conclusion. In conclusion, this study showed the alterations in ALFF and fALFF in three frequency bands between patients with acute BGIS and HCs. The results reflected that the abnormal LFO amplitude might be related with different frequency bands and promoted our understanding of pathophysiological mechanism in acute BGIS.

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Alterations of Functional Connectivity in Stroke Patients With Basal Ganglia Damage and Cognitive Impairment

Cited by 28 publications

References 44 publications

Montreal Cognitive Assessment of cognitive dysfunction after basal ganglia stroke

Montreal Cognitive Assessment of cognitive dysfunction after basal ganglia stroke

Montreal Cognitive Assessment of cognitive dysfunction after basal ganglia stroke

Frequency-Specific Changes of Amplitude of Low-Frequency Fluctuations in Patients with Acute Basal Ganglia Ischemic Stroke

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