The riddle of L-glucose pentaacetate insulinotropic action (review).

Malaisse, Willy

doi:10.3892/ijmm.2.4.383

Cited by 3 publications

(2 citation statements)

References 1 publication

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“…However, it has been reported that the pancreas contains a molecule related to the perception of bitterness, alpha-gustducin, which is also found in the tongue [6,11]. In this context, it can be said that at least two kinds of molecules related to the perception of taste are present in both the tongue and pancreas.…”

Section: Discussionmentioning

confidence: 99%

Expression of the Sweet Receptor Protein, T1R3, in the Human Liver and Pancreas

Taniguchi

2004

J. Vet. Med. Sci.

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ABSTRACT. The expression of T1R3, a taste receptor essential for the perception of sweetness and umami-taste, was examined by immunohistochemistry to determine whether and where it may be localized in the liver and pancreas. In the liver, both immunopositive and immunonegative reactions were detected; bile ducts and intercalated portions of the bile ductules were immunopositive to T1R3, while arterioles and venules were immunonegative in interlobular connective tissue. In the hepatic lobule, all other cells including liver cells (hepatocytes) and bile capillaries were immunonegative. In the pancreas, all endocrine portions of the pancreas were immunonegative to T1R3. Within the exocrine portions, immunopositive reactions were detected in excretory duct cells, intercalated cells, and centroacinar cells. In contrast, acinar cells were immunonegative, as were vessels, lymph capillaries, nerve fibers, and connective tissue cells in the exocrine portions. The restricted localization of T1R3 in the duct cells of the liver and pancreas in the present study may indicate that T1R3 is involved in monitoring changes in the makeup of bile and pancreatic juices in the hepatic and pancreatic duct systems.

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Section: Discussionmentioning

confidence: 99%

Expression of the Sweet Receptor Protein, T1R3, in the Human Liver and Pancreas

Taniguchi

2004

J. Vet. Med. Sci.

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“…(E.g. the acetate derivative of L-glucose is found to stimulate insulin release, but it is produced synthetic [43]).…”

Section: Carbohydratesmentioning

confidence: 99%

The Role of Carbohydrates at the Origin of Homochirality in Biosystems

Toxværd

2013

Orig Life Evol Biosph

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Pasteur has demonstrated that the chiral components in a racemic mixture can separate in homochiral crystals. But with a strong chiral discrimination the chiral components in a concentrated mixture can also phase separate into homochiral fluid domains, and the isomerization kinetics can then perform a symmetry breaking into one thermodynamical stable homochiral system. Glyceraldehyde has a sufficient chiral discrimination to perform such a symmetry breaking.The requirement of a high concentration of the chiral reactant(s) in an aqueous solution in order to perform and maintain homochirality; the appearance of phosphorylation of almost all carbohydrates in the central machinery of life; the basic ideas that the biochemistry and the glycolysis and gluconeogenesis contain the trace of the biochemical evolution, all point in the direction of that homochirality was obtained just after-or at a phosphorylation of the very first products of the formose reaction, at high concentrations of the reactants in phosphate rich compartments in submarine hydrothermal vents.A racemic solution of D,L-glyceraldehyde-3-phosphate could be the template for obtaining homochiral D-glyceraldehyde-3-phosphate(aq) as well as L-amino acids.

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Effect ofD-mannoheptulose upon the cationic and secretory responses to α-D-glucose pentaacetate in perifused rat pancreatic islets

Jijakli¹,

Malaisse²

1999

Endocr

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The metabolism of alpha-D-glucose pentaacetate and its positive insulinotropic action in isolated rat pancreatic islets are both unexpectedly resistant to D-mannoheptulose, as judged from experiments conducted over 90-120 min incubation. In the present study, the possible effects of the heptose upon the immediate cationic and secretory response to the ester were investigated in perifused islets prelabeled with either 86Rb or 45Ca. At a 10 mM concentration, sufficient to abolish the inhibitory action of unesterified D-glucose upon 86Rb outflow, D-mannoheptulose failed to suppress the decrease in 86Rb outflow and increase in 45Ca efflux caused by alpha-D-glucose pentaacetate at normal extracellular Ca2+ concentration and also failed to prevent the decrease in both 45Ca and insulin release provoked by the ester in the absence of extracellular Ca2+. The sole obvious effect of the heptose was to change the early peak-shaped positive secretory response to alpha-D-glucose pentaacetate to a transient inhibition of insulin release. This change was observed in islets either deprived of any other exogenous nutrient or exposed to L-leucine throughout the experiments. These findings support the view that the islet functional response to alpha-D-glucose pentaacetate is largely resistant to D-mannoheptulose. They also reinforce the concept that the insulinotropic action of this and other monosaccharide esters involves a dual modality of B-cell activation, linked to both the catabolism of their carbohydrate moieties and a direct effect of the esters themselves upon a specific receptor system.

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The riddle of L-glucose pentaacetate insulinotropic action (review).

Cited by 3 publications

References 1 publication

Expression of the Sweet Receptor Protein, T1R3, in the Human Liver and Pancreas

Expression of the Sweet Receptor Protein, T1R3, in the Human Liver and Pancreas

The Role of Carbohydrates at the Origin of Homochirality in Biosystems

Effect ofD-mannoheptulose upon the cationic and secretory responses to α-D-glucose pentaacetate in perifused rat pancreatic islets

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