Expression of the Sweet Receptor Protein, T1R3, in the Human Liver and Pancreas

Taniguchi, Kazumi

doi:10.1292/jvms.66.1311

Cited by 58 publications

(40 citation statements)

References 20 publications

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“…The T1R genes were found in testis (91,92,120), brain, thymus (120), gastrointestinal tract, enteroendocrine cells (24,53,120,146), kidney, lymphocytes (92), liver, and pancreas (158). The T2R genes were found in testis (118), gastrointestinal tract, enteroendocrine cells (146,174,175), and nasal respiratory epithelium (55).…”

Section: Aqp5mentioning

confidence: 99%

Taste Receptor Genes

Bachmanov

Beauchamp²

2007

Annu. Rev. Nutr.

388

381

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In the past several years, tremendous progress has been achieved with the discovery and characterization of vertebrate taste receptors from the T1R and T2R families, which are involved in recognition of bitter, sweet, and umami taste stimuli. Individual differences in taste, at least in some cases, can be attributed to allelic variants of the T1R and T2R genes. Progress with understanding how T1R and T2R receptors interact with taste stimuli and with identifying their patterns of expression in taste cells sheds light on coding of taste information by the nervous system. Candidate mechanisms for detection of salts, acids, fat, complex carbohydrates, and water have also been proposed, but further studies are needed to prove their identity.

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Section: Aqp5mentioning

confidence: 99%

Taste Receptor Genes

Bachmanov

Beauchamp²

2007

Annu. Rev. Nutr.

388

381

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“…T1R2-T1R3 is expressed in many tissues throughout the body, including the intestine , liver (Taniguchi 2004), pancreas (Taniguchi 2004), adipocytes (Masubuchi et al 2013), and brain (Ren et al 2009). T1R2-T1R3 agonists enhance intestinal glucose absorption ), incretin response (Brown et al 2009), insulin secretion (Pepino et al 2013), and adipocyte differentiation (Masubuchi et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Lipid-Lowering Pharmaceutical Clofibrate Inhibits Human Sweet Taste

Kochem

Breslin

2016

CHEMSE

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T1R2-T1R3 is a heteromeric receptor that binds sugars, high potency sweeteners, and sweet taste blockers. In rodents, T1R2-T1R3 is largely responsible for transducing sweet taste perception. T1R2-T1R3 is also expressed in non-taste tissues, and a growing body of evidence suggests that it helps regulate glucose and lipid metabolism. It was previously shown that clofibric acid, a blood lipid-lowering drug, binds T1R2-T1R3 and inhibits its activity in vitro. The purpose of this study was to determine whether clofibric acid inhibits sweetness perception in humans and is, therefore, a T1R2-T1R3 antagonist in vivo. Fourteen participants rated the sweetness intensity of 4 sweeteners (sucrose, sucralose, Na cyclamate, acesulfame K) across a broad range of concentrations. Each sweetener was prepared in solution neat and in mixture with either clofibric acid or lactisole. Clofibric acid inhibited sweetness of every sweetener. Consistent with competitive binding, inhibition by clofibric acid was diminished with increasing sweetener concentration. This study provides in vivo evidence that the lipid-lowering drug clofibric acid inhibits sweetness perception and is, therefore, a T1R carbohydrate receptor inhibitor. Our results are consistent with previous in vitro findings. Given that T1R2-T1R3 may in part regulate glucose and lipid metabolism, future studies should investigate the metabolic effects of T1R inhibition.

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“…Recent studies have shown that the T1R family is also expressed in the small intestine and colon. Furthermore, Taniguchi (2004) showed that T1R3 is expressed in the intrahepatic bile duct and pancreas. Thus, the T1R family is expressed in various parts of the digestive system, and it is possible that these receptors may play a role in chemical sensations in these tissues.…”

Section: Discussionmentioning

confidence: 99%

<b>Expression patterns of T1R3 in duodenal epithelial cells with some gastrointestinal hormone</b>

Oda

Seta

Kataoka

et al. 2011

Archives of Histology and Cytology

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may regulate the secretion of serotonin by stimuli other than a mechanical one. IntroductionThe taste system, which is made up of taste receptor cells clustered in taste buds at the surface of the tongue and the soft palate, plays a key role in the decision to ingest or reject food. Its function is therefore, essential to protect organisms against harmful toxins and select the most appropriate nutrients. Ingested nutrients stimulate the secretion of gastrointestinal hormones necessary for the coordinated processes of food digestion.The T1Rs, G-protein-coupled receptors (GPCRs) that form two novel seven-transmembrane domains, are expressed in topographically distinct subpopulations of taste receptor cells and taste buds (Hoon et al., 1999). The functional expression of T1Rs is influenced by sweet and umami taste stimuli. A T1R2/T1R3 heterodimer serves as a chemical receptor for sweet tastes (diverse natural and synthetic sweeteners). T1R1/T1R3 heterodimers are receptors for the umami compound l-glutamate, a response enhanced by 5'-ribonucleotides (Nelson et al., 2001;Li et al., 2002).Recent studies have demonstrated that solitary cells expressing taste cell signal transduction proteins exist in hollow organs. It has been previously shown that T1Rs are expressed in the gastrointestinal tract (GI) (Hofer et al., 1996;Wu et al., 2002; Dyer et al., 2005;Grundy, 2005). They are additionally expressed in the stomach, small intestine -including the duodenum, and colon in mice and humans, with the exception of T1R2, which has not been detected in the mouse or human stomach or in the mouse colon (Bezençon et al., 2007

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Expression of the Sweet Receptor Protein, T1R3, in the Human Liver and Pancreas

Cited by 58 publications

References 20 publications

Taste Receptor Genes

Taste Receptor Genes

Lipid-Lowering Pharmaceutical Clofibrate Inhibits Human Sweet Taste

<b>Expression patterns of T1R3 in duodenal epithelial cells with some gastrointestinal hormone</b>

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