The Revised Diagnostic Interview for Borderlines: Discriminating BPD from other Axis II Disorders

Zanarini, Mary C.; Gunderson, John G.; Frankenburg, Frances R.; Chauncey, Deborah L.

doi:10.1521/pedi.1989.3.1.10

Cited by 546 publications

(362 citation statements)

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“…Their investigation comprised 17 patients with DSM III-R personality disorders, six of which (four women and two men) were clinically diagnosed with BPD. However, the average score on the diagnostic interview for borderlines (DIB; Zanarini et al, 1989) in the BPD group was only 3.7, which is only about half of the usual cut-off score of 7. Thus, the results have to be interpreted with caution.…”

Section: Brain Metabolism Under Resting Conditions Assessed With Fdg-petmentioning

confidence: 81%

Neuroimaging in borderline personality disorder

Schmahl¹,

Bremner²

2006

Journal of Psychiatric Research

170

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Neuroimaging has become one of the most important methods in the investigation of the neurobiological underpinnings of borderline personality disorder. Structural and functional imaging studies have revealed dysfunction in different brain regions which seem to contribute to borderline symptomatology. This review presents relevant studies using different methodologies: volumetry of limbic and prefrontal regions, investigations of brain metabolism under resting conditions, studies of serotonergic neurotransmission, and challenge studies using emotional, stressful, and sensory stimuli. Dysfunction in a frontolimbic network is suggested to mediate much, if not all of the borderline symptomatology.

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Section: Brain Metabolism Under Resting Conditions Assessed With Fdg-petmentioning

confidence: 81%

Neuroimaging in borderline personality disorder

Schmahl¹,

Bremner²

2006

Journal of Psychiatric Research

170

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“…Patients had to fulfill the criteria for BPD according to the Diagnostic and statistical manual of mental disorders, fourth edition (DSM-IV 301.83), 2,20 and the Diagnostic Interview for BPD (DIB). 21 Exclusion criteria were age below 18 or above 40 years; presence of current or lifetime criteria for schizophrenia, schizoaffective disorder, bipolar disorder, current eating disorder, alcohol or substance use disorder; presence of a current major depressive episode; and any other medical or neurological illnesses. The patients had to be free of any psychotropic medication for at least 12 weeks.…”

Section: Methodsmentioning

confidence: 99%

[123I] ADAM and SPECT in patients with borderline personality disorder and healthy control subjects

Schaaff¹,

Koch²,

Pöpperl³

et al. 2007

Pharmacopsychiatry

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Objective: Serotonergic dysfunction is considered to be involved in the pathophysiology of borderline personality disorder (BPD). The aim of this study was to investigate serotonin transporter availability in patients with BPD as a marker of the central serotonergic system. Methods: Eight unmedicated patients with BPD and 9 healthy control subjects received single photon emission computed tomography (SPECT) 4 hours after injection of 185 MBq [I-123] . As a measure of brain serotonin transporter (SERT) availability, ratios of specific-to-nonspecific [I-123] ADAM binding for the brainstem and hypothalamus were calculated with an occipital reference. Levels of impulsiveness and depressive symptoms were assessed with the Barratt Impulsiveness Scale and the Beck Depression Inventory. Results: Mean specific-to-nonspecific ratios showed a 43% higher brainstem and a 12% higher hypothalamus ADAM binding in patients, compared with control subjects. We found significant correlations of ADAM binding with both age and impulsiveness but not depression. Associations of BIS scores with ADAM binding remained significant after controlling for age and depression (r = 0.69, p < 0.01). Conclusion: The study provides evidence of a serotonergic dysfunction in patients with BPD and suggests a serotonergic component in the pathophysiology of the disorder. SERT binding reflected the level of impulsiveness as a common feature in BPD.Objectif : On considère que le dysfonctionnement sérotoninergique joue un rôle dans la pathophysiologie du trouble de personnalité limite (TPL). Cette étude visait à étudier, chez les patients atteints d'un TPL, la disponibilité du transporteur de la sérotonine comme marqueur du système sérotoninergique central. Méthodes : Huit patients atteints d'un TPL qui ne prenaient pas de médicament et neuf sujets témoins en bonne santé ont été soumis à une tomographie d'émission monophotonique (TEM) 4 heures après avoir reçu par injection 185 MBq [I-123] ). Pour mesurer la disponibilité du transporteur de la séroto-nine dans le cerveau (SERT), on a calculé des ratios de fixation spécifique:non spécifique [I-123] d'ADAM dans le tronc cérébral et l'hypothalamus en utilisant un point de référence occipital. On a évalué les niveaux d'impulsivité et de symptômes dépressifs au moyen de l'échelle d'impulsivité de Barratt (EIB) et du questionnaire de dépression de Beck. Résultats : Les ratios de fixation spécifique:non spé-cifique moyens ont montré que la fixation de l'ADAM était plus élevée de 43 % dans le tronc cérébral et de 12 % dans l'hypothalamus chez les patients comparativement aux sujets témoins. Nous avons constaté des liens importants entre la fixation de l'ADAM et à la fois l'âge et l'impulsivité, mais non la dépression. Les liens entre les résultats de l'EIB et la fixation de l'ADAM sont demeurés importants compte tenu de l'âge et de la dépression (r = 0,69, p < 0,01). Conclusion : L'étude présente des preuves de dysfonctionnement séro-toninergique chez les patients atteints de TPL et indique la présence d'un élé...

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“…This suggests that those characteristics that index and/or facilitate positive psychosocial behaviors are helpful for BPD patient improvement. In the MSAD, only approximately 20% of the patients experienced a relapse during the course of the study [38].…”

Section: What Has Been Learned From the New Prospective Studies?mentioning

confidence: 98%

“…Zanarini and colleagues [38] reported on the 10-year course of BPD. In MSAD, BPD was assessed over five 2-year intervals.…”

Section: What Has Been Learned From the New Prospective Studies?mentioning

confidence: 99%

Long-Term Outcomes in Borderline Psychopathology: Old Assumptions, Current Findings, and New Directions

Sanislow

Marcus

Reagan

2011

Curr Psychiatry Rep

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Borderline personality disorder (BPD) and historical variants of the diagnosis were long held to represent an intractable syndrome of psychopathology consisting of interpersonal, intrapsychic, and affective disturbances. For years, patients labeled "borderline" were regarded pejoratively due at least in part to the lack of effective treatments. Prospective data from recent naturalistic follow-along studies along with the development of treatments with empirically demonstrated efficacy have changed how BPD is viewed. It is now less common to hide the diagnosis from the patient, and BPD has become a useful label to guide the treatment process and help the patient make sense of his or her suffering. Although it is now accepted that BPD is a treatment-responsive disorder and that remission is the norm, more work is needed to help patients achieve a higher level of functioning, and targeting persistent trait-like features suggests new directions for future efforts in treatment development.

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The Revised Diagnostic Interview for Borderlines: Discriminating BPD from other Axis II Disorders

Cited by 546 publications

References 1 publication

Neuroimaging in borderline personality disorder

Neuroimaging in borderline personality disorder

[123I] ADAM and SPECT in patients with borderline personality disorder and healthy control subjects

Long-Term Outcomes in Borderline Psychopathology: Old Assumptions, Current Findings, and New Directions

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