The reversible antifertility effect of Piper betle Linn. on Swiss albino male mice

Sarkar, Madhumita; Gangopadhyay, Paramita; Basak, Bidyut; Chakrabarty, Kausiki; Banerji, Julie; Adhikary, P; Chatterjee, A.

doi:10.1016/s0010-7824(00)00177-3

Cited by 59 publications

(27 citation statements)

References 3 publications

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“…The fructose content of the seminal vesicle was decreased significantly (Table 5) ( P < .001). It may be suggested that these compounds hamper the glycolitic metabolism of spermatozoa resulting in abnormal sperm function [47]. The significant ( P < .001) elevation in concentration of testicular cholesterol (Table 5) may indirectly indicate the reduced level of circulating testosterone and thus impairment of spermatogenesis takes place [48].…”

Section: Resultsmentioning

confidence: 99%

Effect of Benzothiazoline Ligand and Corresponding Organoantimony(V) Derivative on the Reproductive System of Male Rats

Shanker

Rai²,

Singh³

et al. 2006

Bioinorganic Chemistry and Applications

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Benzothiazoline HNC6H4SCtrue⎴(C6H5)CH:C(OH)COOCH3 1 prepared by the condensation reaction of aroyl pyruvate and 2-aminothiophenol has been treated with to yield Ph3trueSbfalse[SC6H4NCfalse(C6H5false)CH:CO⎴COOCH3false] 2. These compounds have been characterized by elemental analyses and molecular weight determinations. The probable structures of the ligand as well as antimony complex have been tentatively proposed on the basis of IR and NMR ( and ) spectral evidences. Both compounds have been tested for their antifertility activity in male albino rats. The oral administration of compounds 1 and 2 at the dose level of 10 mg/rat/day significantly reduced the weights of testes, epididymides, ventral prostate, and seminal vesicles. The production of preleptotene spermatocytes was decreased by 36.57%; 57.23%, pachytene spermatocytes by 40.06%; 62.01%, and secondary spermatocytes by 52.45%; 63.22%, following the treatment of compounds 1 and 2, respectively. The marked reduction in sperm motility and density resulted in infertility by 100%. Significant (P < .01) alterations were found in biochemical parameters of reproductive organs in treated animals as compared to control group. It is concluded that all these effects may finally impair the fertility of male rats.

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Section: Resultsmentioning

confidence: 99%

Effect of Benzothiazoline Ligand and Corresponding Organoantimony(V) Derivative on the Reproductive System of Male Rats

Shanker

Rai²,

Singh³

et al. 2006

Bioinorganic Chemistry and Applications

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“…The elevation in the cholesterol content refl ects nonutilization of this substrate for androgen biosynthesis. Depletion in fructose content hampers the glycolytic metabolism of spermatozoa and this results in abnormal sperm function which ultimately leads to complete male sterility [30] .…”

Section: Discussionmentioning

confidence: 99%

Induction of Antifertility with Lupeol Acetate in Male Albino Rats

Gupta¹,

Bhatnager

Joshi³

et al. 2005

Pharmacology

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The present study was undertaken to evaluate the antifertility activity of the active principle, i.e. lupeol acetate, isolated from benzene extract of Alstonia scholaris in male albino rats. The treatment with lupeol acetateat the dose level of 10 mg/rat/day did not cause any significant change in the body weights, but significant reduction in the weight of reproductive organs, i.e. testes, epididymides, seminal vesicle and ventral prostate, was observed. Testicular sperm count, epididymal sperm count and motility were found significantly declined when compared with controls, which resulted in reduction of male fertility by 100%. Arrest of spermatogenesis was noted at various stages with production of primary spermatocytes (preleptotene and pachytene), secondary spermatocytes and step-19 spermatids were decreased by 52.36, 54.91, 55.67 and 69.65%, respectively. The seminiferous tubules appeared reduced in size by 24.62%. Cross-sectional surface area of Sertoli cells as well as their counts were found to be significantly depleted. Leydig cell nuclear area and number of mature Leydig cells were decreased by 27.65 and 35.47%. Biochemical parameters of tissues i.e. protein, sialic acid, glycogen and cholesterol content of testes and seminal vesicular fructose also showed significant reduction.

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“…Fructose serves as source of energy for sperm, reduction in the fructose might be due to decreased secretory activity of seminal vesicle [59][60] . Sperm density and motility directly correlates with fertility chances and therefore decreased sperm density [50][51][52][53][54] and motility of spermatozoa might reduced fertility of rats followed extract treatment [61][62][63][64][65][66][67][68][69][70] . A large number of metaphasic cells in the germ epithelium of treated animals might be caused by cell cycle blockage or [46,71] arrest at the spermatid level in the form of degenerative changes in the germinal cells together with few fragmented sperms in the lumen and acquired a thick, irregular basement membrane [72][73][74] .…”

Section: Discussionmentioning

confidence: 99%

Reversible Antifertility Effect of Cassia tora Linn in Male Rats

Khan¹,

Mali²

2017

IJLSSR

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ABSTRACT-Background:Plant Cassia tora has been used in traditional and modern medicines for different pharmacological activities. Objectives: The present investigation has been taken to observe and evaluate effects of Cassia tora on the reproduction functions of male rats in search a safe, orally effective and reversible fertility regulating agent. Materials and Methods: Fifty percent ethanolic extract of Cassia tora was prepared and administered orally in male Wistar rats at the doses of 50, 100 and 200 mg/kg.b.wt./rat/day dose levels respectively for a period of 60 days and some of the treated rats were kept 30 days for recovery of fertility to assessed reversibility effects. Hematological indices, serum clinical investigations were also performed to assess toxic effects if any caused in rats by treatment. Proteins, cholesterol, glycogen, ascorbic acid, sialic acid and fructose level were analyzed in rats. Serum FSH, LH and Testosterone levels were measure. Rats were castrated to evaluate effects on reproductive functions of hormones and mode of action of the Cassia tora treatment. For histopathological observations tissues were fixed in Bouin's fluid, dehydrated, sectioned and stained with Hematoxylin and Eosin. Results: Treatment of Cassia tora significantly reduced the weights of testes and accessory sex organs. Sperm density and motility were declined high significantly. Levels of Testosterone and FSH hormone were significantly decreased in rats. The protein, sialic acid, fructose, ascorbic acid and glycogen contents of reproductive accessory sex organs were decreased significantly. Germinal epithelium of testes degenerated and number of spermatocytes, spermatids and spermatozoa in lumen of seminiferous tubules reduced. Conclusions:The decreased testes and accessory sex organs weights, sperm motility, density and testosterone level in rats might be due to androgen suppression effects of Cassia tora treatment cause inhibition of spermatogenesis resulted reduction of fertility in treated male rats.

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The reversible antifertility effect of Piper betle Linn. on Swiss albino male mice

Cited by 59 publications

References 3 publications

Effect of Benzothiazoline Ligand and Corresponding Organoantimony(V) Derivative on the Reproductive System of Male Rats

Effect of Benzothiazoline Ligand and Corresponding Organoantimony(V) Derivative on the Reproductive System of Male Rats

Induction of Antifertility with Lupeol Acetate in Male Albino Rats

Reversible Antifertility Effect of Cassia tora Linn in Male Rats

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