“The return of ceramic implants”: Rose stem inspired dual layered modification of ceramic scaffolds with improved mechanical and anti-infective properties

Li, Chen; Ai, Fanrong; Miao, Xinxin; Liao, Hang; Li, Fengshun; Liu, Mingzhuo; Yu, Fen; Dong, Lei; Li, Ting; Wang, Xiaolei

doi:10.1016/j.msec.2018.08.044

Cited by 16 publications

(12 citation statements)

References 28 publications

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“… Released ions Antibacterial mechanisms Bacteria used for antibacterial assays Ref. Alkali and alkaline earth ions CaO–P 2 O 5 –SiO 2 –RbO MBG scaffold; Forsterite scaffold Ca 2+ , Na + , Mg 2+ , Rb + Inducing the increase of solution pH and osmotic pressure S. aureus , E. coli , S. epidermidis, P. aeruginosa [ 30 , [57] , [58] , [59] , [60] , [61] , [62] ] Heavy metal ions Ag@rGO modified β-TCP scaffold Ag + Inducing ROS; Breaking bacterial cell membranes S. aureus , E.coli, Bacillus subtills [ 19 , 35 , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] ] PCL/SiO 2 –CaO–P 2 O 5 –ZnO MBG scaffold Zn 2+ Destabilizing membrane and enhancing permeability; Deactivating nucleic acids and enzymes; Killing bacterial by inducing ROS E. coli , S. aureus [ [75] , [76] , [77] , [78] , [79] , [80] , [81] ] SiO 2 –CaO–P 2 O ...…”

Section: Bioceramic-based Scaffolds With Ion-mediated Antibacterial F...mentioning

confidence: 99%

“…Znic (Zn), which has good osteogenesis, vascularization, and antibacterial property, is primarily derived from metal zinc, zinc salt compounds and zinc oxide, where controlled release of zinc ions is important for bioceramic-based scaffolds [ [75] , [76] , [77] , [78] , [79] ]. For example, the PCL/SiO 2 –CaO–P 2 O 5 –ZnO MBG scaffold was prepared by using the sol-gel method and 3D printing, and the mesoporous structure of MBG induced its good degradability, bioactivity and antibacterial properties [ 77 ].…”

Section: Bioceramic-based Scaffolds With Ion-mediated Antibacterial F...mentioning

confidence: 99%

“…Obviously, the scaffolds would be a viable choice for bone regeneration applications due to its bioactivity and antibacterial property. Furthermore, the researchers of another work [ 78 ] fabricated one kind of yttrium oxide-stabilized zirconium oxide (3Y–ZrO 2 ) scaffolds using 3D printing and coated them with nanoscale zinc oxide. It was proven by in vitro and in vivo evaluations that the as-prepared hip prosthesis could exactly match the corresponding parts, as well as exhibit high biocompatibility and outstanding antibacterial activity.…”

Section: Bioceramic-based Scaffolds With Ion-mediated Antibacterial F...mentioning

confidence: 99%

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Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: A review

Zhao

Liu

Zhu

et al. 2022

Bioactive Materials

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Section: Bioceramic-based Scaffolds With Ion-mediated Antibacterial F...mentioning

confidence: 99%

Section: Bioceramic-based Scaffolds With Ion-mediated Antibacterial F...mentioning

confidence: 99%

Section: Bioceramic-based Scaffolds With Ion-mediated Antibacterial F...mentioning

confidence: 99%

See 1 more Smart Citation

Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: A review

Zhao

Liu

Zhu

et al. 2022

Bioactive Materials

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“…The hydroxyapatite based scaffold can not only supply certain mechanical support in the local area, but also constantly release some bioactive elements to the external environment, such as calcium, phosphorus, which are beneficial for tissue repair [43]. Bioinert ceramics like alumina ceramics, glass ceramics, single crystal ceramics, and zirconia ceramics have stable chemical properties [44]. Additionally, these inorganic implants can be further modified by some drugs to make them multifunctional.…”

Section: Inorganic Scaffolds For Drug Loadingmentioning

confidence: 99%

Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

et al. 2020

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Liposome is one of the most commonly used drug delivery systems in the world, due to its excellent biocompatibility, satisfactory ability in controlling drug release, and passive targeting capability. However, some drawbacks limit the application of liposomes in clinical, such as problems in transporting, storing, and difficulties in maintaining the drug concentration in the local area. Scaffolds usually are used as implants to supply certain mechanical supporting to the defective area or utilized as diagnosis and imaging methods. But, in general, unmodified scaffolds show limited abilities in promoting tissue regeneration and treating diseases. Therefore, liposome-scaffold composite systems are designed to take advantages of both liposomes' biocompatibility and scaffolds' strength to provide a novel system that is more suitable for clinical applications. This review introduces and discusses different types of liposomes and scaffolds, and also the application of liposome-scaffold composite systems in different diseases, such as cancer, diabetes, skin-related diseases, infection and human immunodeficiency virus, and in tissue regeneration like bone, teeth, spinal cord and wound healing.Journal Pre-proof Drug-loaded liposomesLiposomes have been widely investigated as drug carriers, from the approved amphotericin B liposome in 1990 to the successful Onivyde™ in 2015. As drug carriers, liposomes have several advantages, for instance, they can carry various types of drugs, specifically, the internal water core can load hydrophilic drugs and the bilayers can carry hydrophobic ones. Additionally, liposomes exhibit the ability in controlling the drug release and decreasing the side effect of drugs. Furthermore, liposomes also show advantages in low toxicity, non-immunogenic and biodegradability. The phospholipid bilayer can be regarded as satisfactory platforms that can be modified with diverse ligands to achieve the goal of targeting delivery. Furthermore, the stability and efficacy of biological products can also be improved by utilizing liposomes as vehicles. Delivering small molecule hydrophilic drugsSeveral methods, such as reverse evaporation, pH gradient, ammonium sulfate gradient and repeated freeze thawing, are usually applied in the process of preparing small hydrophilic drugs-loaded liposomes. For example, Takeuchi et al. [14] fabricated polyborane encapsulated liposomes though pH gradient or reverse-phase evaporation, then they found that for the encapsulation efficiency of the liposome Journal Pre-proof 6 prepared using the pH gradient was twice as high as that prepared, using reverse-phase evaporation. Additionally, they observed that boron concentration of the polyborane encapsulated liposomes prepared using the pH gradient achieved 110-150 μg/g of tumor tissue. Delivering small molecule hydrophobic drugsUsually the film dispersion method is one of the simplest ways to fabricate lipid drug-loaded liposomes. For example, Fu et al.[15] fabricated novel temperature-sensitive liposomes loading paclitaxel (PTX-...

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“…Li et al implemented nano ZnO and isocyanate (ISO) resin dual layered modification on 3Y-ZrO 2 ceramic implants. The ZnO-ISO modified surfaces are endowed with antibacterial activity against S. aureus and E. coli [ 29 ]. Li et al constructed a hybrid coating consisting of ZnO, SiO 2 , and polystyrene-acrylic acid (PSA) nanoparticles on Ti surfaces.…”

Section: Chemical Treatments With Metallic Agentsmentioning

confidence: 99%

Metallic Antibacterial Surface Treatments of Dental and Orthopedic Materials

et al. 2020

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The oral cavity harbors complex microbial communities, which leads to biomaterial-associated infections (BAI) during dental and orthopedic treatments. Conventional antibiotic treatments have met great challenges recently due to the increasing emergency of drug-resistant bacteria. To tackle this clinical issue, antibacterial surface treatments, containing surface modification and coatings, of dental and orthopedic materials have become an area of intensive interest now. Among various antibacterial agents used in surface treatments, metallic agents possess unique properties, mainly including broad-spectrum antibacterial properties, low potential to develop bacterial resistance, relative biocompatibility, and chemical stability. Therefore, this review mainly focuses on underlying antibacterial applications and the mechanisms of metallic agents in dentistry and orthopedics. An overview of the present review indicates that much work remains to be done to deepen the understanding of antibacterial mechanisms and potential side-effects of metallic agents.

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“The return of ceramic implants”: Rose stem inspired dual layered modification of ceramic scaffolds with improved mechanical and anti-infective properties

Cited by 16 publications

References 28 publications

Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: A review

Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: A review

Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

Metallic Antibacterial Surface Treatments of Dental and Orthopedic Materials

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