The Resurgence of Paperfluidics: A new technology for cell, DNA, and blood analysis

Fish-scale waste to portable bioactive discs: a sustainable platform for sensitive and reliable blood group analysis

“…The highly porous nature of a paper stack allows the creation of easily accessible analytes and necessary gradients across them: the very reason for implementing paperfluidics in diverse diagnostic applications. 26 However, our bio-discs are based on instant lateral wicking (Fig. 2f) through capillary action accommodating chromatography-based analysis.…”

“…the very reason for implementing paperuidics in diverse diagnostic applications. 26 However, our bio-discs are based on instant lateral wicking (Fig. 2f) through capillary action accommodating chromatography-based analysis.…”

“…In this perspective, paperuidic device have been emerging as affordable, eco-friendly, easy-to-use and reliable point-of-care diagnostics. 5,6,[26][27][28][29] Unlike microuidics, the principle of blood typing using paperuidics is based on the inherent properties of paper, including the composition, porosity, absorption, capillary movement, wicking-based lateral ow and hydrophilicity, which can drastically inuence the sample ow, sample interaction and RBC separation, interfering with test accuracy. 2,27,30,31 When papers with different basic weights composed of various bres were analysed for blood grouping, hardwood bre paper with high porosity demonstrated superior performance over paper generated using sowood bres.…”

Point-of-Care Strategies Applied to Malaria Diagnosis

“…Microfluidics can be divided in conventional and paper-based assays. Conventional microfluidics focuses on miniaturizing regular laboratory protocols, with a special emphasis on integration of all necessary elements for the diagnostic reaction into stand-alone systems [54,56]. In conventional microfluidic systems, liquid control can be exerted by acoustic, mechanical, magnetic, as well as capillary and centrifugal forces.…”

“…Paper-based systems, on the other hand, rely mostly on the power of capillary forces, passively controlling liquid flow via hydrophilic and hydrophobic interactions. However, paper-based assays can integrate sample preparation and pre-concentration more easily than conventional microfluidic systems [56].…”