The Results of Low-Dose Total Skin Electron Beam Radiation Therapy (TSEB) in Patients With Mycosis Fungoides From the UK Cutaneous Lymphoma Group

Morris, Stephen; Scarisbrick, Julia; Frew, J.; Irwin, Clive; Grieve, Robert; Humber, C.; Kuciejewska, Aleksandra; Bayne, Sally; Weatherhead, Sophie; Child, Fiona; Wain, Mary; Whittaker, Sean

doi:10.1016/j.ijrobp.2017.05.052

Cited by 60 publications

(62 citation statements)

References 18 publications

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“…A statistically significantly higher rate of complete remissions was achieved in patients treated with high doses as compared to studies, which used low-dose schemes (14)(15)(16), which is also consistent with our observations. Mean PFS was 60.6 months and 38.7 months for patients treated with 20-34 Gy and 34-40 Gy, respectively (Table I).…”

Section: Discussionsupporting

confidence: 91%

Total Skin Electron Beam Therapy with Rotary Dual Technique as Palliative Treatment for Mycosis Fungoides

Piotrowski

Fundowicz

Pawlaczyk

2018

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Section: Discussionsupporting

confidence: 91%

Total Skin Electron Beam Therapy with Rotary Dual Technique as Palliative Treatment for Mycosis Fungoides

Piotrowski

Fundowicz

Pawlaczyk

2018

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“…They showed an overall response rate (ORR) of 88%, with a median duration of clinical benefit of 70·7 weeks . A series of low‐dose TSEB (12 Gy in eight fractions over 2 weeks) in 103 patients has shown a similar very high ORR, with a median duration of response of 18 months in patients with stage IB MF and 10 months in patients with stage IIB MF, with significantly less toxicity than standard‐dose TSEB . Studies of low‐dose TSEB in combination with newer agents are currently under way.…”

Section: Treatment Of Mycosis Fungoides/sézary Syndromementioning

confidence: 99%

“…TSEB is a highly effective treatment for MF with excellent complete response rates for all stages . EORTC consensus guidelines for the use of TSEB in CTCL have been published .…”

Section: Treatment Of Mycosis Fungoides/sézary Syndromementioning

confidence: 99%

British Association of Dermatologists and U.K. Cutaneous Lymphoma Group guidelines for the management of primary cutaneous lymphomas 2018

et al. 2018

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“…Currently, low-dose TSEBT is commonly used because this approach involves a short course of radiation, and patients report superior tolerability [14][15][16][17]. While TSEBT is one of the most effective modalities for treatment of cutaneous lymphoma, measuring TLD is time consuming and limits the availability of TSEBT at many institutions.…”

Section: Introductionmentioning

confidence: 99%

In-vivo dosimetric analysis in total skin electron beam therapy

Elsayad¹,

Moustakis²,

Simonsen

et al. 2018

Physics and Imaging in Radiation Oncology

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Background and purpose: Thermoluminescent dosimetry (TLD) is an important element of total skin electron beam therapy (TSEBT). In this study, we compare radiation dose distributions to provide data for dose variation across anatomic sites. Materials and methods: Retrospectively collected data on 85 patients with cutaneous lymphoma or leukemia underwent TSEBT were reviewed. Patients were irradiated on two linear accelerators, in one of two positions (standing, n = 77; reclined, n = 8) and 1830 in vivo TLD measurements were obtained for various locations on 76 patients. Results: The TLD results showed that the two TSEBT techniques were dosimetrically heterogeneous. At several sites, the dose administered correlated with height, weight, and gender. After the first TLD measurement, fourteen patients (18%) required MU modification, with a mean 10% reduction (range, −25 to +35). Individual TLD results allowed us to customize the boost treatment for each patient. For patients who were evaluated in the standing position, the most common underdosed sites were the axilla, perineum/perianal folds, and soles (each receiving 69%, 20%, and 34% of the prescribed dose, respectively). For patients evaluated in a reclining position, surface dose distribution was more heterogeneous. The sites underdosed most commonly were the axilla and perineum/perianal folds (receiving less than one third of prescribed dose). Significant variables were detected with model building. Conclusion: TLD measurements were integral to quality assurance for TSEBT. Dose distribution at several anatomical sites correlated significantly with gender, height, and weight of the treated individual and might be predicted.

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The Results of Low-Dose Total Skin Electron Beam Radiation Therapy (TSEB) in Patients With Mycosis Fungoides From the UK Cutaneous Lymphoma Group

Cited by 60 publications

References 18 publications

Total Skin Electron Beam Therapy with Rotary Dual Technique as Palliative Treatment for Mycosis Fungoides

Total Skin Electron Beam Therapy with Rotary Dual Technique as Palliative Treatment for Mycosis Fungoides

British Association of Dermatologists and U.K. Cutaneous Lymphoma Group guidelines for the management of primary cutaneous lymphomas 2018

In-vivo dosimetric analysis in total skin electron beam therapy

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