The Response of the Tongue Epithelial on Cigarette Smoke Exposure as a Risk Factor for Oral Cancer Development

Prasetyaningtyas, Neken; Jatiatmaja, Nabilah Azzahra; Radithia, Desiana; Hendarti, Hening Tuti; Parmadiati, Adiastuti Endah; Hadi, Priyo; Mahdani, Fatma Yasmin; Ernawati, Diah Savitri; Zain, Rosnah Binti; Ayuningtyas, Nurina Febriyanti

doi:10.1055/s-0040-1721312

Cited by 13 publications

(14 citation statements)

References 25 publications

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“…This results in genetic differences that are influential in cell division such as p53 so that susceptibility to genetic mutations is different between individual rats. 35 A previous study conducted by Prasetyaningtyas et al 17 and Ayuningtyas et al 36 showed that cigarette smoke exposure can increase the dysplasia degree and induce the risk of oral cancer development due to increased number of macrophages, lymphocytes, and MMP-9 expressions in the tongue epithelium.…”

Section: Discussionmentioning

confidence: 98%

Malondialdehyde Level and Tissue Apoptosis Count as an Early-Detection Marker of Oral Potentially Malignant Disorders

et al. 2022

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Objectives The malondialdehyde (MDA) level and TA count represent the progression of oral potentially malignant disorders (OPMD) to malignancy and thus may be used as an indicator of oral epithelial dysplasia (OED). This study aimed to determine the MDA level and tissue apoptosis (TA) count in oropharyngeal tissue of Wistar rats exposed to sidestream cigarette smoke. Materials and Methods Wistar rats were divided into three groups: T4 group (4-week cigarette smoke exposure), T8 group (8-week cigarette smoke exposure), and control group, which was not exposed to cigarette smoke. The oropharyngeal tissue of the rats from each group was examined histopathologically to count the number of apoptotic cells, and then the blood serum was made to measure the MDA level. Statistical Analysis Bonferroni test was performed to see the differences in each group for MDA level. While the data from tissue apoptosis were analyzed using Mann-Whitney U test for the significance. All data were considered significant if p < 0.05. Results The MDA level and TA count increased as the duration of cigarette smoke exposure increased. In the T8 group, the MDA level and TA count were significantly higher compared with the T4 and control groups with a p-value < 0.05. Conclusions Exposure to sidestream cigarette smoke increased the TA count and MDA level in the oropharyngeal tissue of Wistar rats. The TA count and MDA level may be used as markers of OPMD.

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Section: Discussionmentioning

confidence: 98%

Malondialdehyde Level and Tissue Apoptosis Count as an Early-Detection Marker of Oral Potentially Malignant Disorders

et al. 2022

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“…However, smoking and chronic irritation caused by ill-fitting dentures, as well as swallowing and inhaling environmental carcinogens at elevated internal body temperature, have been proposed to play a role in the development of malignant lesions. 3,9 Clinically, oral melanoma demonstrates as a slow-growing, asymptomatic, brown, purple, or black pigmentation with irregular borders and may appear as a rapidly expanding mass with or without ulceration. 1,10 The clinical differential diagnosis should exclude oral melanoma from normal variations 11 and other benign, harmless black lesions such as melanotic macule, smoker's melanosis, amalgam and graphite tattoos, and pigmented nevus.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Large Oral Melanoma: A Case Report of a Rare but Aggressive Malignancy

2021

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A variety of black-pigmented lesions of the oral cavity can be found, ranging from harmless benign lesions such as melanotic macule, smoker’s melanosis, amalgam/graphite tattoos, and pigmented nevus to a life-threatening oral malignant melanoma. Oral melanoma is a rare and aggressive malignant tumor that originates from melanocytes’ proliferation and accounts for only 0.5% of all oral malignancies. The etiology is unknown. Most oral melanomas are present at the palate and the upper alveolar ridge, whereas occurrences at the buccal mucosa, the lower alveolar ridge, and the lip are rare, with only a few reports in the literature. The diagnosis is confirmed by a biopsy. The prognosis is poor, with a 5-year survival rate of ~20%. In this report, we present a case of large oral melanoma at the right buccal mucosa involving the right lower alveolar ridge and lip commissure, which are relatively unusual locations for oral melanoma. In addition, immunohistochemical markers used for diagnostic, therapeutic, and prognostic decision-making of oral melanoma are also discussed.

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“…This was in accordance with previous studies. [23][24][25][26][27] Smoking induces oral cancer risk development [28] Cigarettes contains N-nitrosamines and nicotine which lead to DNA mutations. This mutation encourages tu-mor initiation and promotion.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of SOX2 and GPC3 in Ameloblastoma and its malignant counterpart (Ameloblastic Carcinoma)

Hasan

Nagdy

Ibrahim

2021

JST

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Background: Ameloblastoma is a common benign aggressive odontogenic tumor with a tendency for high recurrence rate. Ameloblastic Carcinoma is the malignant counterpart of Ameloblastoma. However, they are usually difficult to be distinguished from one another. Therefore, using Immunohistochemical markers might be beneficial for diagnosing them accurately.Objective: Evaluation of SOX2 and GPC3 expressions as well as evaluating their roles in the tumorigenesis and the biological behavior of Ameloblastoma and Ameloblastic Carcinoma.Methods: Tissue samples are composed of 34 archived histopathologically confirmed cases of (19 Conventional Ameloblastomas, and 15 Ameloblatic Carcinomas). Sections were subjected to Immunohistochemical staining according to a standard protocol by applying antibodies to SOX2, and GPC3.Results: SOX2 and GPC3 expressions in recurrent Ameloblastoma were significantly higher than non- recurrent cases. Ameloblastic Carcinoma showed the highest immune-reactivity to SOX2 and GPC3 compared to the Conventional Ameloblastoma. Desmoplastic Ameloblastoma showed the highest scores of SOX2 and GPC3 compared to the other subtypes.Conclusions: SOX2 and GPC3 can be used as a panel for diagnosing the aggressive and the malignant odontogenic tumors accurately. Desmoplastic Ameloblastoma behaves more aggressively than other Conventional Ameloblastoma subtypes.

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The Response of the Tongue Epithelial on Cigarette Smoke Exposure as a Risk Factor for Oral Cancer Development

Cited by 13 publications

References 25 publications

Malondialdehyde Level and Tissue Apoptosis Count as an Early-Detection Marker of Oral Potentially Malignant Disorders

Malondialdehyde Level and Tissue Apoptosis Count as an Early-Detection Marker of Oral Potentially Malignant Disorders

A Large Oral Melanoma: A Case Report of a Rare but Aggressive Malignancy

Prognostic significance of SOX2 and GPC3 in Ameloblastoma and its malignant counterpart (Ameloblastic Carcinoma)

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