The response of rosacea to eradication of<i>Helicobacter pylori</i>

Son, Sang Wook; Kim, I H; Oh, Chi Hyuk; Kim, J G

doi:10.1046/j.1365-2133.1999.02852.x

Cited by 31 publications

(27 citation statements)

References 7 publications

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“…Since then, several studies have shown an elevated prevalence of H. pylori infection in patients with rosacea (15,(26)(27)(28), even when compared with age-and sex-matched control patients (29). In contrast, other authors could not show a higher prevalence of infection in these patients (4,(30)(31)(32)(33)(34).…”

Section: Resultscontrasting

confidence: 38%

“…There have been few studies in the literature that have considered rosacea types. In a study published in 1999, Son et al (33) found no significant differences in the outcome of rosacea after eradication depending on the type of rosacea. Contrarily, Suarez et al (36) in 1999 demonstrated improved cutaneous symptomatology in 64% of papulopustular rosacea patients and only 14.3% of erythematous patients, which represents similar results to those described in the present study.…”

Section: Resultsmentioning

confidence: 99%

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Effect of Helicobacter pylori eradication therapy in rosacea patients

Miquel

Romero

Sequeiros

et al. 2006

Rev. esp. enferm. dig.

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Objective: the causal relation between rosacea and Helicobacter pylori infection is discussed. We evaluated the clinical evolution of rosacea after infection eradication.Patients and methods: we have prospectively studied 44 patients diagnosed with rosacea. Helicobacter pylori infection was determined, and infected patients were treated with eradication therapy. The evolution of dermatological symptoms in a subgroup of 29 infected patients in whom eradication had been achieved was followed during 16.8 (± 17.8) months. Median age was 50.6 (± 14.1) years for 22 women (75.9%) and 7 men (24.1%). Clinical response according to gender and clinical subtype of rosacea was evaluated.Results: complete improvement was observed in 10 patients (34.5%; 95% CI: 18.6-54.3%), relevant improvement in 9 (31.1%; 95% CI: 16-51%), poor improvement in 5 (17.2%; 95% CI: 6.5-36.4%), and absence of improvement in 5 cases (17.2%; 95% CI: 6.5-36.4%). No significant differences in dermatological evolution according to sex were observed. Regarding subtype of rosacea there was a relevant improvement in 83.3% (95% CI: 64.1-93.8%) of cases with papulopustular type as opposed to 36.5% (95% CI: 20-56.1%) of cases with erythematous predominance, p = 0.02.Conclusions: based on these results, the relation between Helicobacter pylori and rosacea is supported, and infection should be investigated in these patients because an appreciable percentage of patients diagnosed with rosacea and Helicobacter pylori infection can benefit from eradication therapy, mainly in the papulopustular subtype.

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Section: Resultscontrasting

confidence: 38%

Section: Resultsmentioning

confidence: 99%

Effect of Helicobacter pylori eradication therapy in rosacea patients

Miquel

Romero

Sequeiros

et al. 2006

Rev. esp. enferm. dig.

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“…Although the etiology of the disease is not fully understood, a genetic predisposition, gastrointestinal diseases, changes in weather conditions, psychogenic factors, seborrhea, changes in vascular mediating mechanisms, mediators such as substance P, histamine, serotonin or prostaglandin and Demodex folliculorum have been incriminated as causing rosacea [1, 2, 3, 4, 5, 6, 7, 8]. In view of the fact that no factors incriminated in the etiopathogenesis of the disease are definitely established and that the disease shows recurrences, the effectiveness of available treatment modalities and their side effects should be evaluated.…”

Section: Introductionmentioning

confidence: 99%

Permethrin 5% Cream versus Metronidazole 0.75% Gel for the Treatment of Papulopustular Rosacea

et al. 2002

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Background: Permethrin 5% cream used against human ectoparasites suggests that it may be effective in papulopustular rosacea. Methods: This study included 63 patients diagnosed as having papulopustular rosacea based on the clinical and histological findings. Patients were randomly assigned into permethrin (n = 23), metronidazole (n = 20) and placebo (n = 20) groups. Scores of erythema, telangiectasia, edema and rhinophyma and the numbers of papules, pustules, inflammatory nodules and Demodex folliculorum were determined. Twenty-three patients were given permethrin 5% cream (Zalvor 5% skin cream^®), 20 patients metronidazole 0.75% gel (Roza gel^®) and 20 patients placebo cream (Basis cream^®), in packages looking identical to those of metronidazole and permethrin creams, and were recommended to apply them to their faces twice a day. All patients were also given SPF 20 cream for protection against sunlight. Two months of treatment were planned, and the patients were invited to the clinic for fortnightly controls. Scores of erythema, telangiectasia, edema and rhinophyma and the numbers of papules, pustules, inflammatory nodules and D. folliculorum were recorded at each visit. The mean scores of erythema and the mean numbers of papules, pustules and D. folliculorum were determined at baseline and on days 15, 30, 45 and 60. Side effects were also detected. Results: The effect of permethrin 5% cream on D. folliculorum was superior to that of metronidazole 0.75% gel. The effect of permethrin 5% cream on erythema and papules was found to be more effective than placebo and as effective as metronidazole 0.75% gel. However, it had no effect on telangiectasia, rhinophyma and pustules. Conclusion: It can be concluded that the application of permethrin 5% cream twice daily for 2 months can be as effective and reliable as metronidazole in the treatment of rosacea and a greater benefit can be gained when it is combined with other systemic and/or topical treatments.

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“…However, there is still a lot of debate in the medical literature regarding whether or not HP has a high prevalence in RS patients. While some articles rule out this association (12)(13)(14)(15), others confirm a statistic significant association HP -inflammatory papulopustular RS (16). Szlachcic et al proved that RS is associated with a high virulent strain of HP.…”

Section: Results Resultsmentioning

confidence: 99%

Rosacea and its comorbidities

Merticariu¹,

Marinescu²,

Giurcăneanu³

2016

JTMR

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Objectives: Rosacea is currently defined as an inflammatory cutaneous disease without systemic echoes. The objective of our paper is to review the published articles to confirm our belief that rosacea is associated to or can predispose to various diseases, mainly inflammatory diseases. Material and methods:Review all the papers published in the last two decades in PubMed, Google Academic and Medscape databases, linking rosacea and various disorders of the body systems. Results: We found that rosacea is associated to several illnesses of major systems (gastrointestinal, cardiovascular, respiratory) and that there are also links between rosacea and immune system disorders and psychiatric diseases. Rosacea clinical course can be influenced by various drugs prescribed for the previous mentioned diseases. Conclusions: Rosacea should no longer be considered a localized cutaneous condition but rather a complex pathology with systemic reverberation. Patients suffering of severe forms of rosacea for a long period of time should have a careful evaluation of body systems.

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The response of rosacea to eradication ofHelicobacter pylori

Cited by 31 publications

References 7 publications

Effect of Helicobacter pylori eradication therapy in rosacea patients

Effect of Helicobacter pylori eradication therapy in rosacea patients

Permethrin 5% Cream versus Metronidazole 0.75% Gel for the Treatment of Papulopustular Rosacea

Rosacea and its comorbidities

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