The Respiratory System

Stookey, J. L.; Moe, James B.

doi:10.1007/978-1-4612-9942-4_2

Cited by 11 publications

(17 citation statements)

References 41 publications

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“…No enveloped particles could be found in extranuclear or extracellular locations. The inclusion bodies and tissue response are similar to those described for adenoviruses in other animals, notably those found in the respiratory tract of primates, dogs, mice, and several avian species [7]. Ultrastructurally, three distinct types of intranuclear electron-dense material are easily discerned ( fig.…”

supporting

confidence: 65%

Naturally Occurring Virus-associated Respiratory Disease in Two Guinea Pigs

Brennecke¹,

Dreier²,

Stokes³

1983

Vet Pathol

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Respiratory disease is a common cause of morbidity in the guinea pig, and is chiefly of bacterial origin [6, 71. Although a variety of viral diseases do occur in the guinea pig, there has been only one previous report of cavian respiratory disease associated with what was believed to be an adenovirus [6] and none reported in the U.S. We report here two cases of pneumonia associated with a virus morphologically similar to adenovirus.Two adult, female Hartley Crl:(HA/BR) guinea pigs being used in anthrax vaccine trials showed clinical signs of hunched posture, weight loss, rough hair coat, rapid labored breathing, and a catarrhal exudate around the external nares and on the front feet. Guinea pig 1 had received five injections of an experimental anthrax vaccine at two-day intervals, while guinea pig 2, as part of the control group, had received five saline injections at the same intervals. Of the other 1 18 guinea pigs in the experiment, three had died prior to this small outbreak but were not submitted for histological examination.Guinea pig 1 died six days after the fifth injection. Guinea pig 2 was moribund and was killed the same day. Gross necropsy findings were similar for both guinea pigs. A catarrhal exudate was found throughout the entire upper respiratory tract and formed a brown crust around the external nares. All lung lobes remained partially distended with well-delineated, variably-sized reddish foci. The left caudel lobe of guinea pig 1 was markedly reddened over much of the lobe. No other significant gross lesions were noted. Aerobic bacterial cultures of lung, liver, and middle ears had no growth. No pathogenic species were isolated from bacterial cultures of proximal tracheal and pharyngeal swabs.The lungs were perfused via the trachea with 10% buffered formalin and then immersed with other samples of all organs in the same fixative. Organ sections were embedded in paraffin, sectioned at 6 Fm, and stained with hematoxylin and eosin (HE).Several I-mm' pieces of lung containing bronchioles were selected under a dissecting microscope, post-fixed in 1% OsO, in phosphate buffer, dehydrated in an ethanol series, and embedded in epon. Sections were cut and stained with uranyl acetate and lead citrate. and examined on an electron microscope at 80 kV.Histologic examination revealed that bronchial and bronchiolar lumens were occluded with necrotic debris and sloughed epithelial cells ( fig. la, Ih). While the majority of bronchioles had no viable epithelium remaining (fig. la), others had intact or hyperplastic epithelial cells ( fig. Ih). Both sloughed and intact epithelial cells had large basophilic intranuclear inclusion bodies: the sloughed cells were more prominent. The peribronchiolar stroma was infiltrated densely with lymphocytes, macrophages, and occasionally neutrophils. The lung parenchyma contained foci of alveolar septa1 thickening due to proliferating lining cells and infiltration of macrophages, lymphocytes, and a few neutrophils. Numerous small to extensive areas of congestion could be seen...

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supporting

confidence: 65%

Naturally Occurring Virus-associated Respiratory Disease in Two Guinea Pigs

Brennecke¹,

Dreier²,

Stokes³

1983

Vet Pathol

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“…However, in the present lesions, foreign bodies were not found in the serial sections at all. Interstitial pneumonia due to Pneumocystis carinii, which has been reported in other kinds of animals [1][2][3]5], seems unlikely in the present cases because no such organ or characteristic lesions were detected. Instead, bacterial clumps were recognized in granulomas of some animals.…”

mentioning

confidence: 48%

Interstitial Pneumonia in Guinea Pigs

Yamasaki

Fukushima

1986

Experimental Animals

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“…These parasites are most commonly seen in New World monkeys (marmosets, squirrel monkeys, cebus monkeys, and howler monkeys) [63,148,207,290,339,461,623,650,742,791,820,865,919].…”

Section: Pulmonary Nematodiasismentioning

confidence: 99%

“…Adults are found in the terminal brochioles, respiratory bronchioles, and pulmonary aveoli [290,461,650,791,820]. The adult female is viviparious.…”

Section: Pulmonary Nematodiasismentioning

confidence: 99%

The Pathoparasitology of Nonhuman Primates: A Review

Toft¹

1986

Primates

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The Respiratory System

Cited by 11 publications

References 41 publications

Naturally Occurring Virus-associated Respiratory Disease in Two Guinea Pigs

Naturally Occurring Virus-associated Respiratory Disease in Two Guinea Pigs

Interstitial Pneumonia in Guinea Pigs

The Pathoparasitology of Nonhuman Primates: A Review

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