The Resolution of Parsidol

Genzer, Jerome D.; Lewis, Mary N.; McMillan, Freeman H.; King, John A.

doi:10.1021/ja01106a510

Cited by 5 publications

(1 citation statement)

References 7 publications

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“…They possess a broad spectrum of biological activity such as potential cardiovascular agents, antiviral , CNS depressant , bactericidal , ulcer inhibitors , and so on. Furthermore, researchers have also revealed that cyanopyridine derivatives constitute an important class of compounds possessing diverse type of biological properties such as antiparasitic , antiparkinsonian , anticonvulsant , and antihistaminic as well as antihelmintic properties. Many naturally occurring and synthetic compounds bearing pyridine scaffold possess interesting biological properties .…”

Section: Introductionmentioning

confidence: 99%

An Efficient Microwave‐Assisted Synthesis and Antimicrobial Activity of Novel 2‐Amino 3‐Cyano Pyridine Derivatives using Two Reusable Solid Acids as Catalysts

Thakrar

Bavishi

Radadiya

et al. 2013

Journal of Heterocyclic Chem

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Two solid acids, Fe3+ K‐10 montmorillonite clay and HY‐zeolite, have been employed efficiently for synthesis of 2‐amino 3‐cyano pyridines 4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j, 4k, 4l, 4m, 4n, 4o, 4p, 4q, 4r, 4s, 4t, 4u, 4v, 4w, 4x by multicomponent reaction of 3‐acetyl 4‐hydroxy coumarin 1a, 1b, 1c, 1,3‐diphenyl‐1H‐pyrazole‐4‐carbaldehyde 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, malononitrile 3, and ammonium acetate. Both the catalysts are recoverable and recyclable. The main significant of this procedure is short reaction time, high yields, easy workup procedure, and being environmentally friendly. The structures of all the compounds have been well characterized by IR, 1H NMR, 13C NMR, and mass spectral data. All the synthesized compounds were screened for their antimicrobial and antifungal activities.

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