The research status of immune checkpoint blockade by anti-CTLA4 and anti-PD1/PD-l1 antibodies in tumor immunotherapy in China

Zhao, Xiaoqin; He, Liangmei; Mao, Kai-yun; Chen, Daming; Jiang, Hong‐Bo; Liu, Zhiping

doi:10.1097/md.0000000000010276

Cited by 5 publications

(10 citation statements)

References 28 publications

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“…19 These reports suggest that trial- and patient-level meta-analyses reach comparable results. 18 In their bibliometrics study, Zhao et al 20 determined that immune checkpoint blockade has developed rapidly, with increasing influence, in the last two decades in China but a relatively large gap remains as compared with the United States. The authors used bibliometrics to analyze the research status of immune checkpoint blockade, a popular tumor immunotherapy method represented by antibodies targeting CTLA-4 and PD-1/PD-L1, in tumor immunotherapy in China during the past two decades.…”

Section: Discussionmentioning

confidence: 99%

“…Second, the steady increase in government investment in drug development can contribute to the rapid growth of research on immune checkpoint blockade for tumor immunotherapy. 20…”

Section: Discussionmentioning

confidence: 99%

“…19 These reports suggest that trial-and patientlevel meta-analyses reach comparable results. 18 In their bibliometrics study, Zhao et al 20 determined that immune checkpoint Table 4. The most contributing meetings in the field of PD-1 and PDL-1.…”

Section: Discussionmentioning

confidence: 99%

“…Second, the steady increase in government investment in drug development can contribute to the rapid growth of research on immune checkpoint blockade for tumor immunotherapy. 20 The present study has some limitations. First, all articles retrieved were from the WoS database; articles from other databases were not included.…”

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confidence: 81%

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A Holistic Evaluation of Articles on PD-1 and PD-L1 Published Between 1975 and 2017: A Bibliometric Analysis

Baş

Şenel

2019

Cancer Inform

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Background: Bibliometrics has been used for assessing and predicting trends in macro-health science and medical systems, especially in the field of cancer. Bibliometric and scientometric studies in the field of programmed cell death 1/programmed cell death 1 ligand 1 (PD-1/PD-L1) may guide further research in this field. Objective: To perform bibliometric analysis of articles on PD-1 and PD-L1 published in the academic literature during 1975 to 2017. Method: The bibliometric analysis was performed using the Thomson Reuters Web of Science database. Results: A total of 23 813 articles were retrieved, 73.52% of which were original articles. The United States was the leading country by total publication number (n = 10 897, 10.91%), followed by China (10.54%), and produced the most literature on PD-1/PD-L1 (164.65 articles). Among the institutions identified, Harvard University (USA) contributed the most articles on PD-1/PD-L1. Conclusions: All authors and institutions in the top 10 contributor’s lists were from the developed countries. Researchers from the developing and least-developed countries should be encouraged to perform novel studies on PD-1 and PD-L1.

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Section: Discussionmentioning

confidence: 99%

“…Second, the steady increase in government investment in drug development can contribute to the rapid growth of research on immune checkpoint blockade for tumor immunotherapy. 20…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 81%

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A Holistic Evaluation of Articles on PD-1 and PD-L1 Published Between 1975 and 2017: A Bibliometric Analysis

Baş

Şenel

2019

Cancer Inform

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“…Bibliometrics is a measurable informatic method that analyses the knowledge structure to obtain quantifiable data and to address the above limitation ( Guo et al, 2020 ; McElroy and Allen, 2020 ; Wang et al, 2020 ). Although there have been several bibliometric studies related to PD1 or PDL1, they usually only focused on some specific aspects such as documents on PD1/PDL1 molecule, anti-PD1/PDL1 therapy in China or for a single kind of cancer ( Zhao et al, 2018 ; Baş and Şenel, 2019 ; Gao et al, 2019 ; Ahn and Hwang, 2020 ; Li et al, 2021 ). Considering that the application of anti-PD1/PDL1 in various cancers is still in exploration, and researchers devote to explore more mechanism of PD1/PDL1 molecule to improve efficacy of immunotherapy, it is necessary to conduct an updated and more comprehensive bibliometric study.…”

Section: Introductionmentioning

confidence: 99%

Trends in the Research Into Immune Checkpoint Blockade by Anti-PD1/PDL1 Antibodies in Cancer Immunotherapy: A Bibliometric Study

et al. 2021

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The programmed death receptor 1 (PD1) and its ligand programmed death receptor ligand 1 (PDL1) are the most widely used immune checkpoints in cancer immunotherapy. The related literature shows the explosive growth trends due to the promising outcomes of tumor regression. The present study aimed to provide a comprehensive bibliometric analysis of the literature on anti-PD1/PDL1 from three perspectives including molecular mechanisms, randomized clinical trials (RCT), and meta-analysis, thus producing a knowledge map reflecting the status of the research, its historical evolution, and developmental trends in related research from 2000 to 2020. We included 11,971, 191, and 335 documents from the Web of Science Core Collection database, respectively, and adopted various bibliometric methods and techniques thereto. The study revealed the major research themes and emergent hotspots based on literature and citation data and outlined the top contributors in terms of journals and countries. The co-occurrence overlay of keywords and terms pertaining to the PD1/PDL1 molecule reflected the progress from the discovery of the PD1/PDL1 molecule to the clinical application of anti-PD1/PDL1. Immune-related adverse events (irAEs) formed a unique cluster in the term co-occurrence analysis of meta-analysis. The historical direct citation network of RCT indicated the development and transformation of cancers and therapy strategies. irAEs and the strategies of combination therapy might become a future focus of research in this cognate area. In summary, the bibliometric study provides a general overview of the landscape on anti-PD1/PDL1 research, allowing researchers to identify the potential opportunities and challenges therein.

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Evaluation of the 101 most cited immunology articles: A bibliometric analysis

Hanci

2023

Medicine

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In our study, the 101 most cited publications in the field of “Immunology” in the Web of Science (WoS) database were evaluated bibliometrically. The “WoS” database “advanced mode" was used in this study. A search was conducted in the field of “Immunology.” The top 101 most-cited publications were then identified. The total number of citations of the publications, annual number of citations, authors, information of the study, and journal were analyzed. There were 1,191,384 publications in the field of “Immunology” in the WoS between 1975 and 2023. The total citation average of the 101 most cited publications was 3765.69 ± 4142.7 and the annual citation average was 180.91 ± 133.1. The first 3 subjects in the first 101 articles were listed as “apoptosis–cancer immunology” (14.85%), “monocyte-macrophage”(14.58%), and “T-cell”(13.86%), respectively. The 3 journals in which the studies were published the most were determined as “Annual Review of Immunology” (18.81%), “Nature Reviews Immunology” (17.82%) and “Nature Immunology” (10.89%). Only 1.98% of publications were published after 2014. A significant relationship was found between the study type, impact factor of the journal, continent of journal and publisher, funding status, year of publication, and number of citations per year (P < .05). Our study is the first to analyze the top 101 most-cited studies in the field of “immunology" and their citation characteristics. The study’s journals, publishers, publication features, funding status, and publication year affect the number of citations per year.

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The research status of immune checkpoint blockade by anti-CTLA4 and anti-PD1/PD-l1 antibodies in tumor immunotherapy in China

Cited by 5 publications

References 28 publications

A Holistic Evaluation of Articles on PD-1 and PD-L1 Published Between 1975 and 2017: A Bibliometric Analysis

A Holistic Evaluation of Articles on PD-1 and PD-L1 Published Between 1975 and 2017: A Bibliometric Analysis

Trends in the Research Into Immune Checkpoint Blockade by Anti-PD1/PDL1 Antibodies in Cancer Immunotherapy: A Bibliometric Study

Evaluation of the 101 most cited immunology articles: A bibliometric analysis

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