The Reproductive Tract

King, Norval W.

doi:10.1007/978-1-4612-9942-4_7

Cited by 33 publications

(19 citation statements)

References 133 publications

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“…In males, this inhibition is not clearly demonstrated because the mechanism is only short term. In general, ovarian atresia, ovarian cysts or tumors, and testicular atrophy are described in the ageing population [King, 1978;Bureck, 1978], But this is not the case for M. murinus and we think that these anomalies as deter mined by gonadotropic disturbances are due to emotional stimuli according to modem conception [Greer and Morris, 1975;Henry and Stephens, 1977], Lastly, some alimentary factors may intervene to strengthen sexual pathology: (a) underfeeding which induces anemia and also a rise of gluco corticoid secretion [Edozien et al, 1978;Bajaj et al, 1979] and (b) lack of vitamin A or E? If the diet in captivity contains appreciable quantities of these vitamins, we cannot exclude the possibility of a reduced intestinal absorption (lipids lacking in diet) or inadequate storage (fatty liver).…”

Section: Resultsmentioning

confidence: 99%

“…In the female mouse lemur, the endometrium which was injured by the tumor would not play its luteolytic role and corpora lutea may persist. These retained corpora lutea may promote growth of these tumors (King, 1978]. In these condi tions, most of the states 4 found in weakened females do probably not reflect a normal estrous cycle.…”

Section: Repartition O F Sexual Statesmentioning

confidence: 99%

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Stress-effects in Microcebus murinus

Perret¹

1982

IJFP

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Histological investigations were made over a 10-year period on 164 lesser mouse lemurs that died spontaneously in captivity. The principal lesions found were chronic nephrosis with nephritis which affects 90% of the animals, myocardial necrosis, respiratory insufficiency induced by interstitial pneumonia, fatty changes in the liver, and splenic and gastric lesions. The following are associated with these pathologies: progressive hypothyroidism, stable hypercorticism, slight medulloadrenal hyperactivity, and sexual disorders such as testicular atrophy in males and estrous cycle disturbance or uterine tumor in females. All these data were treated by correspondence analysis; this showed that, except for some rare cases of death which can be attributed to massive parasitic infestation or generalized cancer, the whole captive population of lesser mouse lemurs is suffering from a syndrome that leads to renal insufficiency and death. Most of the observed pathologies are considered as being associated with aging in mammals. But captive Microcebus murinus died between 3 and 4 years of age, whereas their potential life survival is 13 years. Our hypothesis is that these pathologies arise due to an overload of cortico- and medulloadrenal secretions. The above-mentioned hormonal imbalance could be induced by stress factors occurring in captivity, the most important of which would be social stress.

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Section: Resultsmentioning

confidence: 99%

Section: Repartition O F Sexual Statesmentioning

confidence: 99%

Stress-effects in Microcebus murinus

Perret¹

1982

IJFP

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“…These cysts vary in size and may be single or multiple (Plates 15 and 16). Cysts frequently secrete estrogen in excessive amounts, resulting in persistent estrus, cystic endometrial hyperplasia, and infertility (14). Cystic endometrial hyperplasia of the uterus is extremely common in B6C3F1 mice, with an incidence greater than 35% (15).…”

Section: Cystsmentioning

confidence: 99%

“…The ovaries from such animals have few or no corpora lutea, atypical cystic follicles, and abundant stroma. Hypophysectomized an- (14).…”

Section: Cystsmentioning

confidence: 99%

Nonneoplastic lesions of the ovary in Fischer 344 rats and B6C3F1 mice.

Montgomery

Alison

1987

Environ Health Perspect

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The National Toxicology Program's pathology database on 2-year carcinogenicity studies was reviewed for nonneoplastic ovarian disease. Ovaries from 39,941 female Fischer rats and 41,444 female B6C3F1 mice were examined. A variety of inflammatory, degenerative, vascular, and proliferative lesions were documented and are described. The most common ovarian lesions in rats were cysts (6%). The most frequent ovarian lesions in mice were cysts (15%), acute inflammation (4%), degeneration (4%), vascular disease (2.5%), and atrophy (2%). There was no difference in incidence of ovarian disease between controls and treated animals. The frequency of ovarian disease in mice exceeded the frequency in rats in every category.

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“…Spontaneous spermatic granuloma in the epididymis is known to occur in domestic and laboratory animals [2][3][4] However, this condition has been described only rarely in dogs and the morphological changes involved have not been studied thoroughly. We recently encountered the epididymal spermatic granuloma in a dog, and the present paper describes the morphological changes found in this condition.…”

mentioning

confidence: 99%