The Reproductive Characteristics of Diabetic Men

Babbott, David; Rubin, Alan M.; Ginsburg, Silas J.

doi:10.2337/diab.7.1.33

Cited by 30 publications

(11 citation statements)

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“…7 A). In this experiment, cultures were maintained for 4 d in order to demonstrate the stimulatory action of estradiol. In addition, insulin significantly amplified the dose-dependent stimuilatory effects of 8-bromo cAMP assessed after 44 h (Fig.…”

Section: Methodsmentioning

confidence: 99%

“…For example, men with diabetes mellitus exhibit reproductive impairment and impotence, children manifest delayed puberty, and women have an increased prevalence of anovulation, menstrual irregularity, and infertility (4)(5)(6)(7)(8)(9)(10). Presumptive abnormalities of both pituitary and gonadal function have been described in vivo (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). However, the interpretation of these observations is limited by confounding influences of weight loss, protein catabolism, hyperglycemia, gonadal vasculopathy, and homeostatic responses of the pituitary-gonadal and adrenal axes in intact animals (15)(16)(17)(18)(19)(20)(21)(22).…”

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confidence: 99%

“…The actions of insulin are exerted by processes that require protein and RNA synthesis, and by mechanisms that augment mitochondrial cytochrome P-450 content and facilitate the utilization of cholesterol in the side-chain cleavage INTRODUCTION Hypogonadism is a recognized sequela of insulinopenic diabetes mellitus in experimental animals and man (1)(2)(3)(4)(5)(6). For example, men with diabetes mellitus exhibit reproductive impairment and impotence, children manifest delayed puberty, and women have an increased prevalence of anovulation, menstrual irregularity, and infertility (4)(5)(6)(7)(8)(9)(10). Presumptive abnormalities of both pituitary and gonadal function have been described in vivo (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

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confidence: 99%

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Mechanisms subserving the trophic actions of insulin on ovarian cells. In vitro studies using swine granulosa cells

Veldhuis¹,

Kolp²,

Toaff³

et al. 1983

J. Clin. Invest.

108

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A B S T R A C T Direct actions of insulin on gonadal tissues have been difficult to demonstrate in vivo. We have developed an in vitro system in which swine ovarian cells remain highly responsive to trophic actions of insulin. Purified porcine insulin significantly augmented the biosynthesis and secretion of progesterone by cultured granulosa cells. These stimulatory actions of insulin were dose-and time-dependent and saturable. Under serum-restricted conditions, insulin also significantly amplified the capacity of estradiol and 8-bromo cyclic AMP to stimulate progesterone production. Inhibitors of protein and RNA synthesis (cycloheximide, actinomycin D, and alpha-amanatin) inhibited insulin action. The stimulation of progesterone production by insulin was attributable to increased biosynthesis of pregnenolone, rather than diminished catabolism of progesterone to its principal metabolite, 20a-hydroxypregn-4-en-3-one. Insulin also enhanced progesterone production in the presence of a soluble sterol substrate, 5-cholesten-3j3,25-diol, which readily gains access to the mitochondrial cholesterol side-chain cleavage system. Moreover, exposure of granulosa cells to insulin produced a three-to sevenfold increase in mitochondrial content of cytochrome P-450 measured by difference spectroscopy, with a corresponding increase in mitochondrial cholesterol side-chain cleavage activity.The capacity of insulin to facilitate progesterone biosynthesis by ovarian cells was mimicked by the insulinlike somatomedin, multiplication stimulating activity, but not by epidermal growth factor, fibroblast growth factor, or porcine relaxin. Insulin's augmentation of progesterone production reflected a selective action on progestin biosynthesis, since insulin significantly suppressed estrogen biosynthesis by granulosa cells.Thus, our investigations indicate that insulin acts on ovarian cells selectively to stimulate pregnenolone (but not estrogen) biosynthesis. The actions of insulin are exerted by processes that require protein and RNA synthesis, and by mechanisms that augment mitochondrial cytochrome P-450 content and facilitate the utilization of cholesterol in the side-chain cleavage 1046 J. Clin. Invest.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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Mechanisms subserving the trophic actions of insulin on ovarian cells. In vitro studies using swine granulosa cells

Veldhuis¹,

Kolp²,

Toaff³

et al. 1983

J. Clin. Invest.

108

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“…Reproductive function in the human male is markedly affected by the diabetic state with its associated presence of hyper¬ glycaemia. Diabetic men have been reported to have an increased incidence of impotence (Schoffling et al, 1963), a decreased sperm count (Babbott et al, 1958), poor sperm motility (Klebanow & MacCleod, 1960) and atrophie changes in the germinal epithelium of the testes (Babbott et al, 1958). These data imply that D-glucose is a potent factor in testicular function.…”

Section: Introductionmentioning

confidence: 56%

TEMPORARY STERILITY PRODUCED IN MALE MICE BY 5-THIO-d-GLUCOSE

Zysk¹,

Bushway²,

Whistler³

et al. 1975

Reproduction

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Summary. When 5-thio-D-glucose was fed to male mice at daily dose levels greater than 30 mg/kg sperm development was completely inhibited within 3 weeks and remained so without impairment of libido for the experimental period of 7 weeks. Removal of this substance from the diet resulted in a resumption of sperm development and fertility within 5 to 8 weeks. Normal litters were sired by males which had recovered after this treatment.

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“…Kellock [4] confirmed J ackson's findings but sug gested as a possible explanation that diabetics and future diabetics tend to marry women who are also potential diabetics. Babbot et al [5] and R ubin [6] could find no difference between the birth weights of infants of a group of diabetic men and a control group of healthy men.…”

Section: Discussionmentioning

confidence: 99%

Studies in Human Reproduction Glucose Tolerance in Mothers and Fathers of Excessive-Sized Infants

Goldman¹,

Schachter²

1974

Gynecol Obstet Invest

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It is now known that a woman who has given birth to a large child or children is to be regarded as a potential diabetic. It has also been suggested that, in addition to the mother’s unfavorable environment, the high birth weight might be an inherited characteristic linked in some way to the diabetic genetic make-up of the father. The authors have investigated carbohydrate metabolism by means of a 3-hour oral glucose tolerance test in 50 couples, mothers and fathers who had given birth to giant infants (weighing 5 kg or more). Glucose tolerance was compared to that of 50 other couples, mothers and fathers of infants with average birth weight. The latter served as a control group. Nine women (18%) in the test group had a diabetic O-GTT, as compared to three (6%) in the control group. Five men in the test group (10%), and two in the control group (4%) had diabetic-type curves. Statistical evaluation of women and men as groups showed glucose tolerance to be significantly lower in the test groups as compared to the control groups, respectively. It was concluded that results of our study are in accordance with investigators who found deterioration of carbohydrate metabolism in mothers and fathers of excessive-sized babies.

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The Reproductive Characteristics of Diabetic Men

Cited by 30 publications

References 0 publications

Mechanisms subserving the trophic actions of insulin on ovarian cells. In vitro studies using swine granulosa cells

Mechanisms subserving the trophic actions of insulin on ovarian cells. In vitro studies using swine granulosa cells

TEMPORARY STERILITY PRODUCED IN MALE MICE BY 5-THIO-d-GLUCOSE

Studies in Human Reproduction Glucose Tolerance in Mothers and Fathers of Excessive-Sized Infants

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