The Reproducibility of the Rebreathing Method for Assessing the Respiratory Response to Inhaled CO2

Lyall, J. R. W.; Bourne, P. R.; Cameron, I. R.

doi:10.1042/cs049008pa

Cited by 2 publications

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“…This reTationslip could be piotted by the computer on an X-Y recorder, thus establishing a permanent record of the parameters (Clarkson, Leitch & McHardy, 1979). Mean values for Sco2and BC02 were derived from three studies on each occasion in each subject in order to minimise differences due to the known variability of CO2 response measurements by the Read technique (Lyall, Bourne & Cameron, 1975).…”

Section: Introduction Methodsmentioning

confidence: 99%

“…Both these observations suggest that catecholamines may have a central effect on ventilation but are inconsistent with much animal and human experimental evidence indicating that catecholamines influence ventilation only by mechanisms mediated through the carotid bodies and that these effects are blocked by hyperoxia Cunningham, Hey, Patrick & Lloyd, 1963;Joels & White, 1968;Heistad, Wheeler, Mark, Schmid & Abboud, 1972 X-Y recorder, thus establishing a permanent record of the parameters (Clarkson, Leitch & McHardy, 1979). Mean values for Sco2and BC02 were derived from three studies on each occasion in each subject in order to minimise differences due to the known variability of CO2 response measurements by the Read technique (Lyall, Bourne & Cameron, 1975).…”

Section: Introduction Methodsmentioning

confidence: 99%

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Failure of propranolol and metoprolol to alter ventilatory responses to carbon dioxide and exercise.

Leitch¹,

Hopkin²,

Ellis³

et al. 1980

Brit J Clinical Pharma

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Neither propranolol (80 mg) nor metoprolol (100 mg) give orally to eight normal subjects altered mean ventilatory responses to carbon dioxide or to moderate graded exercise. Incremental doses of the drugs to totals of 320 mg propranolol and 400 mg metoprolol also did not effect these ventilatory responses. Both drugs markedly decreased the heart rate response to exercise. Neither propranolol nor metoprolol are likely to cause CO2 retention by an effect on the ventilatory responses to inhaled carbon dioxide or to exercise.

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Section: Introduction Methodsmentioning

confidence: 99%

Section: Introduction Methodsmentioning

confidence: 99%

Failure of propranolol and metoprolol to alter ventilatory responses to carbon dioxide and exercise.

Leitch¹,

Hopkin²,

Ellis³

et al. 1980

Brit J Clinical Pharma

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Respiratory Effects and Amnesia After Premedication With Morphine or Lorazepam

Cormack

MlLLEDGE

Hanning

1977

British Journal of Anaesthesia

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Lorazepam, a new benzodiazepine, was compared with morphine for premedication. Ten patients received morphine 10 mg/70 kg i.m. and 10 received lorazepam 4 mg/70 kg i.m. Respiratory effects were assessed from the change in slope (S) and intercept (B) of the carbon dioxide response line, using a development of Read's rebreathing method. Morphine depressed S by 47% (P less than 0.01), but after lorazepam S increased by 27% (P less than 0.05), neither drug altering B significantly. In two volunteers lorazepam was assessed by both the rebreathing and the steady-state methods; after lorazepam S was smaller by the steady-state than by the rebreathing technique. The findings for lorazepam are consistent with the known effects of sleep on carbon dioxide sensitivity. Amnesia lasting 4-8 h occurred in all patients who received lorazepam so that pain and nausea during this period were not recalled, but no patient who received morphine experienced amnesia. We conclude that lorazepam merits further study, particularly where sedation without respiratory depression is needed, as in obstetrics, and where amnesia for uncomfortable procedures is required.

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The Reproducibility of the Rebreathing Method for Assessing the Respiratory Response to Inhaled CO2

Cited by 2 publications

References 0 publications

Failure of propranolol and metoprolol to alter ventilatory responses to carbon dioxide and exercise.

Failure of propranolol and metoprolol to alter ventilatory responses to carbon dioxide and exercise.

Respiratory Effects and Amnesia After Premedication With Morphine or Lorazepam

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