Failure of propranolol and metoprolol to alter ventilatory responses to carbon dioxide and exercise.

Leitch, A. G.; Hopkin, J. M.; Ellis, D A; Clarkson, DM; Merchant, Sylvia; McHARDY, G. J. R.

doi:10.1111/j.1365-2125.1980.tb05845.x

Cited by 19 publications

(11 citation statements)

References 21 publications

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“…In our study the effects were seen most clearly with the cardioselective drug atenolol. The results with propranolol showed the same trend but with more scatter, possibly because of the much greater variation in plasma levels known to occur follow- Similarly small and frequent adjustments in exercise load were used in the negative study reported by Leitch et al (1980). Although Violante et al (1984) used only 25 watt increments they emphasize that their subjects were physically untrained unlike those of Pearson et al (1979).…”

Section: Discussioncontrasting

confidence: 40%

“…Enhanced hypoxic drive during exercise (Cunningham et al, 1968) may have as its basis increased sympathoadrenal activity. However, several studies have failed to demonstrate an effect on minute ventilation during graded exercise in normal subjects (Pearson, et al, 1979;Leitch et al, 1980;Petersen et al, 1983;O'Neill et al, 1984;McLeod et al, 1985) whereas others have shown reductions in minute ventilation after propranolol at submaximal levels of exercise (Twentyman et al, 1981;Violante et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

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The effects of beta‐adrenoceptor blockade on breathing during progressive exercise in normal man.

Pearson

Morrison

Simpson

1987

Brit J Clinical Pharma

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1 We have studied the effects of single oral doses of 80 mg propranolol and 100 mg atenolol on breathing during progressive exercise in nine healthy men in a double-blind, placebo-controlled experiment. As judged by their effects on exercise heart rate significant levels of P-adrenoceptor blockade were achieved.2 At the two lower levels of work rate (50 watts and 100 watts) minute ventilation on atenolol was lower than on placebo while at the highest level of work (200 watts) minute ventilation was higher on atenolol than on placebo. The regression of VE atenolol on VE placebo was 1.28 which is significantly different from unity (P < 0 001). The results with propranolol were more scattered and failed to reach the 5% level of significance. 3 Effects on the pattern of breathing are small but when minute ventilation is matched with placebo, atenolol results in larger tidal volumes and prolonged inspiratory and expiratory time. 4 These observations are discussed in relation to other work in the literature.

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Section: Discussioncontrasting

confidence: 40%

Section: Introductionmentioning

confidence: 99%

The effects of beta‐adrenoceptor blockade on breathing during progressive exercise in normal man.

Pearson

Morrison

Simpson

1987

Brit J Clinical Pharma

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“…In the recent literature, a controversy exists as to whether f-blockade causes a blunting of the ventilatory response to carbon dioxide with publications supporting (Mustchin, Gribbin, Tattersfield & George, 1976;Patrick & Pearson, 1980) and opposing (Leitch, Hopkin, Ellis, Clarkson, Merchant & McHardy, 1980) this hypothesis. In exercise, fl-blockade has not been associated with an altered ventilatory response in the steady state (Pearson et al 1979;Leitch et al 1980;Conway, 1982), but it has been shown to lower ventilation at the onset ofexercise (Conway, 1982). The present results suggest an attenuation of ventilatory responses in very light exercise (0 W) due to fl-blockade, but less effect during 100 W exercise.…”

Section: Discussionmentioning

confidence: 99%

Alterations in the oxygen deficit‐oxygen debt relationships with beta‐adrenergic receptor blockade in man.

Hughson¹

1984

The Journal of Physiology

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SUMMARY1. The effects of fi-adrenergic receptor blockade (100 mg oral metoprolol) or matched placebo on gas exchange kinetics were studied in six males. Ventilation and gas exchange were monitored in four transitions for each treatment from loadless pedalling (0 W) to a selected work rate (100 W) and back to 0 W. Breath-by-breath data were averaged for analysis.2. Oxygen uptake (Po.) kinetics were significantly slowed at the onset of exercise and recovery by fl-blockade. This resulted in larger oxygen deficit and oxygen debt (671 + 115, 586 ± 87 ml 02, respectively) for fl-blockade than for placebo (497 ± 87, 474+104 ml 02). In addition, oxygen deficit was significantly larger than oxygen debt during fl-blockade tests. These results can be explained by greater utilization of oxygen and creatine phosphate stores as well as anaerobic glycolysis at the onset of 100 W exercise with f-blockade.3. Carbon dioxide output ( rco,) kinetics were significantly slowed by fl-blockade only at the onset of exercise.4. Expired ventilation (VE) kinetics were not affected by f-blockade. At 0 W, )'E was significantly reduced by fl-blockade. Heart rate was lower at all times with fl-blockade. Kinetics of heart rate were not affected.5. These data for Po, kinetics at the start and end of exercise indicate that even in moderate-intensity exercise, lactic acid production can contribute significantly to energy supply. The use ofthe term 'alactic' to describe the deficit and debt associated with this exercise is not appropriate.

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“…In fact, similar studies did not always show consistent results. For instance, all studies performed on healthy subjects who were able to reach high work rates (usually more than 200 W) showed a reduction of oxygen uptake and maximum work capacity after 3-adrenoceptor blockade (Pearson et al, 1979;Anderson et al, 1979;Twentyman et al, 1981;Tesch & Kaiser, 1983;Petersen et al, 1983), whereas no changes were found in studies carried out in subjects unable to reach such work levels, either healthy (Leitch et al, 1980) or suffering from mild hypertension (Fagard et al, 1980).…”

Section: Introductionmentioning

confidence: 99%

Effects of beta‐adrenoceptor blockade on exercise performance and respiratory response in healthy, physically untrained humans.

Violante¹,

Buccheri²,

Brusasco³

1984

Brit J Clinical Pharma

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The effects of propranolol 80 mg orally were compared with those of placebo on the response to a stepwise increasing exercise test in 17 healthy and physically untrained volunteers, of whom eight were female. Propranolol showed no significant effects on maximum work rate or perceived exertion rate. However, submaximal O2 uptake, CO2 output and minute ventilation tended to be lower after propranolol than after placebo. It is concluded that in subjects with a low work capacity, beta‐adrenoceptor blockade does not impair maximal exercise capacity. The mechanisms underlying changes in respiratory response to exercise after propranolol are not fully explained. However, changes in substrate utilisation, the reduction in cardiac output and an alteration in respiratory drive may all be involved.

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Failure of propranolol and metoprolol to alter ventilatory responses to carbon dioxide and exercise.

Cited by 19 publications

References 21 publications

The effects of beta‐adrenoceptor blockade on breathing during progressive exercise in normal man.

The effects of beta‐adrenoceptor blockade on breathing during progressive exercise in normal man.

Alterations in the oxygen deficit‐oxygen debt relationships with beta‐adrenergic receptor blockade in man.

Effects of beta‐adrenoceptor blockade on exercise performance and respiratory response in healthy, physically untrained humans.

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