The reno-protective effects of atorvastatin in crush syndrome and rhabdomyolysis:is there a dilemma?

Acar, Demet; Gülpembe, Mustafa; Yıldız, Can Gökay; Özdamar, Emine Nur; Açıkgöz, Kerem; Çağlar, Ahmet; Cander, Başar

doi:10.3906/sag-1610-48

Cited by 1 publication

(2 citation statements)

References 23 publications

(27 reference statements)

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“…Hind limb compression of both limbs was induced by pushing the tourniquet high onto the rat's thigh for 5 h (5,24). This method was also described in other papers (22,23,25). The experiments of Nishikata opted to use 3 h as the crush time, which found that immunohistological changes and determination of oxidative stress were helpful in evaluating the extent of tourniquet crush, even before changes were observable by hematoxylin and eosin (H&E) staining (26).…”

Section: Compression By Elasticated Materialsmentioning

confidence: 99%

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Systemic Review of Animal Models Used in the Study of Crush Syndrome

Qing

Chen

et al. 2022

Shock

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Crush syndrome (CS), also known as traumatic rhabdomyolysis, is the leading cause of death following extrication from structural collapse due to earthquakes. Due to the unfeasibility of human studies, animal models are used to study crush syndrome pathophysiology, including biochemistry and treatment regimes. The aim of this systematic literature review was to identify the differences and benefits of various animal models used in the study of CS and provide valuable information for design of future research. A systematic search was conducted in two methods: with the filters ''(crush syndrome) AND (crush muscle injury)'' and with the keywords ''(crush syndrome) AND (animal model)'' covering all articles in the PubMed databases. The search generated 378 articles. After screening abstracts, 91 articles were retrieved and read, then 11 repeated articles were removed and 2 reference papers were included. We finally reviewed 82 original articles. There appear to be two primary methods employed for inducing crush syndrome in animal models, which are chemically induced injury and physically induced injury. Chemical method mainly includes intramuscular (IM) injection of tissue extract solution and IM injection of 50% glycerine. Physical method can be classified into invasive and non-invasive physical compression by elasticated material, inflatable band and heavy load. Various species of animals have been used to study CS, including mice (13.4%), rats (68.3%), rabbits (11.0%), canines (4.9%), goats (1.2%), and pigs (1.2%). Small animals are suitable for researches exploring the mechanism of disease or drug efficacy while large animals can work better with clinical application-related researches. In regard to the choice of modeling method, compressing the certain muscle of animals by heavy things is superior to others to cause systemic trauma-related rhabdomyolysis signs. In addition, due to the significant burden of crush injuries on animals, further attention shall be paid to the selection of the most suitable anesthetics and appropriate analgesics.

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Section: Compression By Elasticated Materialsmentioning

confidence: 99%

“…Most experiments incorporated multiple time points for serum markers and tissue samples following decompression (25,41,65). Multiple types of tests were conducted in the animal experiments.…”

Section: Research Indicators and Observationsmentioning

confidence: 99%

Systemic Review of Animal Models Used in the Study of Crush Syndrome

Qing

Chen

et al. 2022

Shock

View full text Add to dashboard Cite

show abstract

The reno-protective effects of atorvastatin in crush syndrome and rhabdomyolysis:is there a dilemma?

Cited by 1 publication

References 23 publications

Systemic Review of Animal Models Used in the Study of Crush Syndrome

Systemic Review of Animal Models Used in the Study of Crush Syndrome

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