2000
DOI: 10.1203/00006450-200011000-00008
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The Renal Hemodynamic Effects of Ibuprofen in the Newborn Rabbit

Abstract: In early childhood, nonsteroidal anti-inflammatory drugs are mainly used to either prevent or treat premature labor of the mother and patent ductus arteriosus of the newborn infant. The most frequently used prostaglandin-synthesis inhibitor is indomethacin. Fetuses exposed to indomethacin in utero have been born with renal developmental defects, and in both the unborn child and the term and premature newborn this drug may compromise renal glomerular function. The latter has in the past also been observed when … Show more

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Cited by 48 publications
(22 citation statements)
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References 41 publications
(33 reference statements)
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“…The final version may differ from this version. The methods used in this study were similar to those described by Prevot et al, 2004, andChamaa et al, 2000.…”
Section: Renal Function Newborn Rabbit Modelmentioning
confidence: 93%
“…The final version may differ from this version. The methods used in this study were similar to those described by Prevot et al, 2004, andChamaa et al, 2000.…”
Section: Renal Function Newborn Rabbit Modelmentioning
confidence: 93%
“…All methods have been described previously (20). Briefly, the rabbits were anesthetized with 25 mg/kg body weight of sodium pentobarbital i.p.…”
Section: Animal Experimentsmentioning
confidence: 99%
“…From this point onward, all animals received a constant infusion of a modified rabbit Ringer solution at a rate of 1 mL · h Ϫ1 · 100 g Ϫ1 birth weight (20).…”
Section: Animal Experimentsmentioning
confidence: 99%
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“…On delivery, the neonate weighted 2500 g and was reviewed by a paediatrician. Antenatal concerns of premature neonatal ductus arteriosus closure, 12,13 haemorrhage, 14 renal dysfunction 15,16 and opioid withdrawal did not eventuate. SB's renal function stabilized but did not fully return to baseline.…”
Section: Case Reportmentioning
confidence: 93%