Ibuprofen-related renal tubular acidosis in pregnancy

Mallett, Andrew; Lynch, Matthew; John, George T.; Healy, Helen; Lust, Karin

doi:10.1258/om.2011.110041

Cited by 7 publications

(8 citation statements)

References 17 publications

(15 reference statements)

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“…For the final analysis, we retained 41 scientific reports published since 1985: 22 from America (United States of America, N = 20; Canada, N = 1; Mexico, N = 1), 12 from Europe (United Kingdom, N = 9; Germany, N = 2; Spain, N = 1), 6 from Australia, and 1 from Asia (Saudi Arabia, N = 1). 2,8-47 Thirty-nine articles were published in English, 1 in Spanish, and 1 in German. The mentioned reports described 50 cases (14 children and 36 adults).…”

Section: Resultsmentioning

confidence: 99%

Ibuprofen-Associated Hypokalemia and Metabolic Acidosis: Systematic Literature Review

et al. 2022

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Objective: Ibuprofen is a widely used nonsteroidal anti-inflammatory drug, which has been occasionally associated with hypokalemia and metabolic acidosis. The objective of this report is to analyze the literature on this issue and to address the underlying pathophysiology. Data Sources: Excerpta Medica, the National Library of Medicine, and Web of Science were searched from inception to July 16, 2021. Study Selection and Data Extraction: Papers reporting individually documented humans on ibuprofen with hypokalemia, acidosis, or both were retained. Data were extracted using a checklist. Data synthesis: For the final analysis, we evaluated 41 reports describing 50 cases (26 males and 24 females; 36 adults and 14 children) with often profound hypokalemia, acidosis, or both after ingestion of ibuprofen. Twenty-six cases were acute and 24 long term. Hypokalemia and acidosis occurred not only after ingestion of very high doses but also after ingestion of moderately high or even normal doses of ibuprofen. Laboratory values consistent with an excessive urinary potassium excretion or an altered urinary acidification were often disclosed in most cases. Discontinuation of ibuprofen resulted in a resolution of hypokalemia and acidosis within days in 47 cases. The course was lethal in 3 cases. Relevance to Patient Care and Clinical Practice: This review highlights potentially fatal side effects of ibuprofen and can help doctors who are confronted with such a situation. Conclusions: These data highlight the potential of ibuprofen to occasionally induce hypokalemia and acidosis of renal origin. Discontinuation of ibuprofen results in a resolution within days.

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Section: Resultsmentioning

confidence: 99%

Ibuprofen-Associated Hypokalemia and Metabolic Acidosis: Systematic Literature Review

et al. 2022

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“…Some renal dysfunction continued after cessation of use and the delivery of the baby. Consensual urinary drug screening detected benzodiazepines, cannabis metabolites, amphetamine-like substances, methadone and opiates [ 57 ]. Most of the people who used analgesics studied in Yemen also used khat (Catha edulis Forsk.)…”

Section: Resultsmentioning

confidence: 99%

“…Current evidence as collated by this review is that nonmedical and extra-medical use of NSAIDs poses significant health risks for individuals. A range of adverse health consequences were described, including nephrotoxicity (acute renal failure and acute interstitial nephritis) [74]; damage to the renal system; asthma exacerbation; gastrointestinal problems [14,49,60,75]; hypertension and other cardiovascular diseases [38]; gastric erosions and ulceration; chronic gastritis; renal necrosis and disease; hepatocyte necrosis [54]; type 1 respiratory failure [5]; oliguria/anuria and gastric bleeds [15]; recurrent hypokalaemia episodes [57,73]; withdrawal symptoms [51]; haematuria, eosinophilia and decreased creatinine clearance [39]. The majority of NSAID overdoses are asymptomatic, which poses a serious risk to people who use NSAIDs excessively without experiencing any noticeable adverse outcomes [35].…”

Section: Theme 3: Adverse Health Effects Of Non-medical and Extra-medical Use Of Nsaidsmentioning

confidence: 99%

A Scoping Review of Non-Medical and Extra-Medical Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

et al. 2021

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Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used medications worldwide and have analgesic, antipyretic and anti-inflammatory properties. Although NSAIDs are recognised as generally safe and effective, non-medical and extra-medical use of these products can occur. Unlike the use of illegal and many prescription drugs, which are subject to extensive research attention, inappropriate use of NSAIDs has been less well investigated. This scoping review collates and describes what is known regarding non-medical and extra-medical use of NSAIDs. In total, 72 studies were included in this scoping review. Three themes emerged from the review: (1) indicative profile of people who engage in non-medical or extra-medical use of NSAIDs; (2) antecedents for non-medical or extra-medical use; and (3) adverse health effects of non-medical and extra-medical use of NSAIDs. The review concluded that there is a need for enhanced patient education, including among sports people; pharmacovigilance in terms of clinician recognition of aberrance; and prescriber and pharmacist awareness of the potential for extra-medical and non-medical use and the related health harms.

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“…In a report by Mallett et al, the patient had a history of ibuprofen and codeine abusing for the previous six years. The cause of the distal RTA in this case appears clearly linked to her substance abuse, and her renal function and potassium requirements significantly improved after stopping ibuprofen and codeine [ 9 ]. In the case by Firmin et al, the previously healthy patient presented with muscle weakness and body pains and was diagnosed with sporadic isolated proximal RTA.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Transient Proximal Renal Tubular Acidosis in Pregnancy

Narcisse

Agarwal

Kumar

2017

Case Reports in Nephrology

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Renal tubular acidosis (RTA) is a disorder that has improper function of renal acid-base regulation and is rarely encountered during pregnancy. Currently, there is no clear evidence on management and outcomes in patients with this condition. We report a case of a previously healthy 23-year-old female at 30 weeks of gestation who presented with proximal RTA and had spontaneous resolution of the condition shortly after delivery.

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Ibuprofen-related renal tubular acidosis in pregnancy

Cited by 7 publications

References 17 publications

Ibuprofen-Associated Hypokalemia and Metabolic Acidosis: Systematic Literature Review

Ibuprofen-Associated Hypokalemia and Metabolic Acidosis: Systematic Literature Review

A Scoping Review of Non-Medical and Extra-Medical Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

A Rare Case of Transient Proximal Renal Tubular Acidosis in Pregnancy

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