A Scoping Review of Non-Medical and Extra-Medical Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Brennan, Rebekah; Wazaify, Mayyada; Shawabkeh, Haneen; Boardley, Ian D.; McVeigh, Jim; Hout, Marie Claire Van

doi:10.1007/s40264-021-01085-9

Cited by 29 publications

(23 citation statements)

References 79 publications

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“…For instance, in these countries, OTC analgesics can be purchased in local supermarkets or at gas stations which might create the impression to the public that these drugs are safer than prescription-only drugs, potentially resulting in higher rates of frequent and problematic use ( 49 ). Finally, the use of inconsistent definitions of abuse and misuse leads to different results in the estimation of NOA abuse between studies ( 19 , 50 ). The development of standardized substance abuse terminology is urgently needed to compare prevalence estimates between countries ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Abuse of Non-opioid Analgesics in Germany: Prevalence and Associations Among Self-Medicated Users

et al. 2022

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BackgroundAbuse of non-opioid analgesics (NOA) is associated with serious health consequences. However, due to inconsistent definitions of NOA abuse, prevalence estimates for the German population are unclear.ObjectivesThis study aimed to estimate the 12-month prevalence of NOA abuse among self-medicated users of these drugs in the general German population and to identify risk factors.MethodsData are from the 2015 Epidemiological Survey of Substance Abuse, a nationally representative sample with 9,204 individuals aged 18–64 years. Classification of NOA abuse was based on self-reported information according to the definition of the ICD-10-GM diagnosis F55.2 abuse of non-dependence producing substances. Multiple logistic regression was performed to examine associations between NOA abuse and sociodemographic, behavioral, and health-related variables.ResultsThe weighted 12-month prevalence of NOA abuse was 14.6% (95%-CI [13.2- 16.0]) among self-medicated users of these drugs. Extrapolation of the proportion of individuals abusing NOA to the German population aged 18 to 64 is 3,243,396 individuals or 6.4% (95%-CI [5.7- 7.1]). Inexplicable physical pain, being underweight, depression, hazardous alcohol use, daily smoking, illegal drug use, and frequent use of NOA (one or more times per week and daily use) were associated with an increased probability of NOA abuse. The use of cannabis was associated with a lower probability of NOA abuse.ConclusionAbuse of NOA is highly prevalent in the German population. Against the background of increasing self-medication of NOA, healthcare providers need to be aware of potential risk factors of abuse to better identify and prevent this problem.

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Section: Discussionmentioning

confidence: 99%

Abuse of Non-opioid Analgesics in Germany: Prevalence and Associations Among Self-Medicated Users

et al. 2022

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“…The top five causes of hospital admissions include serious complications related to the use of these drugs [ 25 ]. This is especially true for over-the-counter drugs from the group of Non-steroidal anti-inflammatory drugs (NSAIDs) [ 13 ], which are responsible for approximately 25% of all drug-related complications [ 10 , 26 , 27 , 28 ].…”

Section: Health Risks Associated With the Use Of Otc Medicinesmentioning

confidence: 99%

The Over-the-Counter Medicines Market in Poland

Lasota

Mirowska‐Guzel

Goniewicz

2022

IJERPH

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The market of over-the-counter drugs, so-called OTC drugs, is a dynamically developing market driven primarily by self-medication. Their use does not require consultation with a physician, and the patients themselves decide to take them. The distribution of OTC medications in the pharmaceutical market in Poland is diversified. These drugs could be purchased at a pharmacy but also at a supermarket, gas station, or via the internet. The low involvement of public funds in spending on drugs, a relatively small percentage of pharmacy sales of reimbursable prescription drugs, and the difficult access to physicians or general consent to drug advertising all create ideal conditions for creating demand for these drugs. Among the European countries, Poland also has the largest share of OTC drugs in the entire pharmaceutical market, and the percentage of OTCs (without supplements) in the whole drug market in Poland continues to grow. Unfortunately, the non-pharmacy market for the sale of OTC drugs is not adequately controlled in practice, and Polish legal regulations regarding the sale of medicines outside pharmacies are among the most liberal in the European Union. However, this does not change the general attitude of consumers toward purchasing OTC drugs. In fact, further growth of the OTC drug market is forecast. Self-medication will undoubtedly play an important role in the trends which may shape this market in the coming years.

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“…We hypothesize that this is because NSAIDs are the most commonly prescribed drug group in Turkey and worldwide. 16 Analysis of the NSAID groups revealed that propionic acid derivatives were the most commonly used (n = 42), followed by acetic acid derivatives (n = 11), acetyl salicylic acid (n = 10), and phenyramidol (n = 8). Acute urticaria was also noted in 13 patients after paracetamol use.…”

Section: Strong Pointsmentioning

confidence: 99%

Etiological causes in patients with acute urticaria and angioedema

Melikoğlu

Pala

Bayraktar

2022

Allergol Immunopathol

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Background: Acute urticaria and angioedema are emergency dermatological conditions associated with various etiologic factors.Objective: To determine the etiological causes in patients with acute urticaria and angioedema, and to investigate whether more than one etiological cause was present, along with the patients’ laboratory values. Methods: The study was conducted in a tertiary hospital with one center. Etiological causes and laboratory parameters in 284 patients diagnosed with acute urticaria and angioedema were retrospectively studied. Results: A total of 284 patients were included in the study. The mean age of the patients was 42.7 ± 15.6 years, where 163 (57.4%) were women and 121 (42.6%) were men. Acute urticaria and angioedema occurred together in 149 (52.5%) patients. At least one precipitating factor among the predisposing risk factors was present in 220 (77.5%) patients, and more than one precipitating factor was found in 51 (18%) patients. Medication use was found in 157 (55.3%) patients and infection in 54 (19%). The development of urticaria after food consumption was noted in nine (3.2%) individuals. A history of infection and medication intake was present in 50 (17.6%) patients. A joint history of food consumption and medication intake was present in only one patient. Elevated C-reactive protein level was found in 178 (62.7%) patients and elevated anti-streptolysin O titer in 41 (14.4%) patients. Vitamin B12 deficiency was found in 116 (40.8%) patients and vitamin D deficiency in 254 (89.4%). Conclusion: Acute urticaria and angioedema may occur as a result of multiple etiological factors, in which different triggers may be present simultaneously..

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A Scoping Review of Non-Medical and Extra-Medical Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Cited by 29 publications

References 79 publications

Abuse of Non-opioid Analgesics in Germany: Prevalence and Associations Among Self-Medicated Users

Abuse of Non-opioid Analgesics in Germany: Prevalence and Associations Among Self-Medicated Users

The Over-the-Counter Medicines Market in Poland

Etiological causes in patients with acute urticaria and angioedema

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