“…Although EDTA has a long-standing history as the agent of choice in Endodontics, researchers have reported its irritating potential 7,[9][10][11] . Recently, EGTA has also been recommended for root canal biomechanical preparation, since it presents a more precise action on calcium ions than EDTA 1,2,9,12,16 . Another chelating agent, CDTA, has also been reported to significantly bind the divalent cation.…”