The reliability of different formulae to predict creatinine clearance

Verhave, Jacobien C.; Baljé-Volkers, Corine; Hillege, Hans L.; Zeeuw, Dick de; Jong, Paul E. de

doi:10.1046/j.1365-2796.2003.01141.x

Cited by 53 publications

(43 citation statements)

References 24 publications

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“…In the septic patients, creatinine clearance (CL CR ) was assessed by the equation (C creatinine in urine ϫ volume urine )/(C creatinine in plasma ϫ urine collection time). In one patient CL CR was estimated by the formula of Cockroft and Gault (29), [(140 Ϫ age) ϫ weight]/(72 ϫ C creatinine in plasma ), because no measured CL CR value was available.…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetics and Pharmacodynamics of Cefpirome in Subcutaneous Adipose Tissue of Septic Patients

Sauermann

Delle‐Karth

Marsik

et al. 2005

Antimicrob Agents Chemother

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The objective of the present study was to evaluate whether cefpirome, a member of the latest class of broadspectrum cephalosporins, sufficiently penetrates subcutaneous adipose tissue in septic patients. After the administration of the drug at 2 g, tissue cefpirome concentrations in septic patients (n ‫؍‬ 11) and healthy controls (n ‫؍‬ 7) were determined over a period of 4 h by means of microdialysis. To assess the antibacterial effect of cefpirome at the target site, the measured pharmacokinetic profiles were simulated in vitro with select strains of Staphylococcus aureus and Pseudomonas aeruginosa. The tissue penetration of cefpirome was significantly impaired in septic patients compared with that in healthy subjects. For subcutaneous adipose tissue, the area under the concentration-versus-time curve values from 0 to 240 min were 13.11 ؎ 5.20 g ⅐ min/liter in healthy subjects and 6.90 ؎ 2.56 g ⅐ min/liter in septic patients (P < 0.05). Effective bacterial growth inhibition was observed in all in vitro simulations. This was attributed to the significantly prolonged half-life in tissue (P < 0.05), which kept the tissue cefpirome levels above the MICs for relevant pathogens for extended periods in the septic group. By consideration of a dosing interval of 8 h, the values for the time above MIC (T > MIC) in tissue were greater than 60% for pathogens for which the MIC was <4 mg/liter in all septic patients. The present data indicate that cefpirome is an appropriate agent for the treatment of soft tissue infections in septic patients. However, due to the high interindividual variability of the pharmacokinetics of cefpirome in tissue, dosing intervals of not more than 8 h should be preferred to ensure that susceptible bacterial strains are killed in each patient.

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Section: Methodsmentioning

confidence: 99%

Pharmacokinetics and Pharmacodynamics of Cefpirome in Subcutaneous Adipose Tissue of Septic Patients

Sauermann

Delle‐Karth

Marsik

et al. 2005

Antimicrob Agents Chemother

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“…It has been objected that true GFR is underestimated by endogenous creatinine clearance, and even more by its surrogate calculated GFR (27). Some studies suggest that the true GFR is underestimated when calculated GFR /60 ml/min, due to too strong effects of age in the formula, while calculated GFR provides a good estimate when GFR is B/60 ml/min (16,17,28).…”

Section: Discussionmentioning

confidence: 99%

Clinically important renal impairment in various groups of old persons

Nygaard

Naik²,

Ruths

et al. 2004

Scandinavian Journal of Primary Health Care

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“…This was because Scr is affected by several factors such as a muscle mass or creatinine generation and Ccr is more reliable in estimating glomerular filtration rate. 9,10 As a result, the severity of preexisting renal dysfunction defined by Ccr was shown to be the most significant factor in predicting the development of CIN ( Table 2). Analysis of individual patients who developed irreversible injury also indicated the advantage of using Ccr; it was lower than 30 ml/min in 8 of 9 patients (Table 3).…”

Section: Clinical Factors Contributing To the Incidence Of Cinmentioning

confidence: 99%

Prophylactic Hemodialysis Does Not Prevent Contrast-Induced Nephropathy After Cardiac Catheterization in Patients With Chronic Renal Insufficiency

Kawashima

Takano

Iino

et al. 2006

Circ J

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Background In Japan, prophylactic hemodialysis has been considered useful for preventing contrast-induced nephropathy (CIN). Method and ResultsTo assess whether hemodialysis prevented CIN, 391 patients (age: 69±8 years, 63 females) with chronic renal insufficiency (CRI, serum creatinine level (Scr) ≥1.3 mg/dl) who underwent cardiac catheterization, were retrospectively analyzed. Patients were divided into 3 categories based on Scr: L (1.3 ≤Scr <2.0 mg/dl, n=332); M (2.0 ≤Scr <3.0 mg/dl, n=49); and H (Scr ≥3.0 mg/dl, n=10). To prevent CIN, 35 category M patients and all category L patients received hydration alone, whereas 14 category M patients and all category H patients received hemodialysis. CIN developed in 48 patients. The incidence of CIN in category H was significantly higher than that in category L or M (H, 40% vs L, 11% or M, 16% (p<0.05)). In category M patients treated with hemodialysis, Scr increased from 2.4±0.3 to 3.0±0.5 mg/dl (p<0.05) within 7 days, and 29% of patients developed CIN. However, in category M patients who did not receive hemodialysis, the Scr did not change (pre, 2.3±0.2 mg/dl to post, 2.2±0.4 mg/dl), and the incidence of CIN was 11%. Conclusion Prophylactic hemodialysis for CRI patients undergoing cardiac catheterization does not prevent CIN. (Circ J 2006; 70: 553 -558)

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The reliability of different formulae to predict creatinine clearance

Abstract: Abstract. Verhave JC, Baljé-Volkers CP, Hillege HL,

Cited by 53 publications

References 24 publications

Pharmacokinetics and Pharmacodynamics of Cefpirome in Subcutaneous Adipose Tissue of Septic Patients

Pharmacokinetics and Pharmacodynamics of Cefpirome in Subcutaneous Adipose Tissue of Septic Patients

Clinically important renal impairment in various groups of old persons

Prophylactic Hemodialysis Does Not Prevent Contrast-Induced Nephropathy After Cardiac Catheterization in Patients With Chronic Renal Insufficiency

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