The relevance of zinc determination in amniotic fluid 1st Communication: Development of the technique and comparative determination of zinc and protein

Kynast, G.; Wagner, Norbert; Saling, E.; Herold, W.

doi:10.1515/jpme.1978.6.5.231

Cited by 14 publications

(13 citation statements)

References 14 publications

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“…instrumental neutron activation analysis äs the method of detection. At an early stage of this study it became clear that our results were considerably lower than any of the values given in the literature (8,9,(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). Thus, in order to provide support for our own results it was essential to devote more attention to the determination of amniotic fluid zinc than was originally intended.…”

contrasting

confidence: 72%

“…The analytical conditions described in the literature for the zinc determination in amniotic fluid contain widely varying procedures for the pre-treatment of the samples. They include recommendations for measuring without treating the sample (8, 9, 19, 21-23), after 1: 10 dilution with distilled water (14,15), after filtration (24, 27-29), after centrifugation (25,26,30), after centrifugation of turbid samples (16)(17)(18) and after precipitation with trichloroacetic acid and centrifugation (31).…”

Section: Comparison Of Determination Methods: Instrumental Neutron Acmentioning

confidence: 99%

“…Prasad (9) found no such correlation which might be possibly attributed to the fact that too few cases were investigated. The most comprehensive study to date on this subject was conducted by Kynast et al (16,17). They were able to prove that the amniotic fluid zinc concentration in the case of hypotrophic newborns is significantly lower after the 37th week of gestation than in a control group of women with normal pregnancies.…”

mentioning

confidence: 99%

“…In the search for methods for the early diagnosis of such deficiency states several investigations haVe al· ready been carried out to determine whether there is a correlation between retarded development of the foetus and the amniotic fluid zinc concentration (9,(14)(15)(16)(17). Favier et al (14,15) observed a relationship between the amniotic fluid zinc concentration and the birth weight of the neonate.…”

mentioning

confidence: 99%

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Determination of Zinc in Amniotic Fluid in Normal and High Risk Pregnancies

Rösick¹,

Rösick²,

Βrätter³

et al. 1983

CCLM

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Summary:Taking the necessary precautions essential for accurate trace element analysis, the zinc concentrations of 227 samples of amniotic fluid taken at term were determined by means of neutron activation analysis. Half of the zinc was found to be bound to the particles present in amniotic fluid. In the control group (123 cases) the zinc concentrations ranged from 25-261 g/l for untreated samples and from 14-143 g/l when the samples were centrifuged for 10 min at 22000g prior to analysis. The values showed log-normal frequency distributions and were lower than any of the values published in the literature to date.No statistically significant differences could be found, when zinc concentrations of various risk groups (mothefs suffering from gestosis or diabetes mellitus, newborns hypo-or hypertrophic, twin births) were compared with the zinc concentration of the control group. The amniotic fluid zinc concentration is not, therefore, a suitable indicator for the diagnosis of distufbances of the embryonic development.

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contrasting

confidence: 72%

Section: Comparison Of Determination Methods: Instrumental Neutron Acmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Determination of Zinc in Amniotic Fluid in Normal and High Risk Pregnancies

Rösick¹,

Rösick²,

Βrätter³

et al. 1983

CCLM

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“…Zinc deficiency may cause hypoalbuminemia and growth retardation. Causes of hypozincemia in the human are genetic factors, nutritional disturbances, drugs, or disease [11]. Zinc plays an important role in the antibacterial activity of AF.…”

Section: Introductionmentioning

confidence: 99%

The concentration of the elements Zn, Cu, Mg, Fe, Na, and K in human amniotic fluid during birth

Anastasiadis¹,

Atassi²,

Rimpler³

1981

Journal of Perinatal Medicine

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Amniotic fluid zinc in risk pregnancies

Laitinen

Siimes

Vgori

et al. 1984

Biol Trace Elem Res

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The zinc concentration of amniotic fluid (AF) of 129 pregnant women was analyzed by the flame atomic absorption spectrometry. This prospective study was performed in order to find out whether the determination of the AF zinc concentration can be used to monitor the growth and development of the fetus. There were two groups of patients: early stage (15th-19th gestation wk) in which the amniocentesis was performed as a prenatal genetic examination, and late stage (26th-40th wk) in which the amniocentesis was performed due to obstetric reasons. The average AF zinc concentrations were 1.2 and 1.0 μmol/L in the early and late gestation group, respectively. The AF zinc concentration did not correlate with the weight, height, or Apgar scores of the newborn nor with the maternal diseases, age, or parity. The AF zinc concentration in the late gestation group was significantly lower if the fetus was male than if it was female. If the AF was greenish the zinc concentration was elevated. One malformation, congenital nephrosis, with an exceptionally high zinc concentration (9.0 μmol/L), was found.

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The relevance of zinc determination in amniotic fluid 1st Communication: Development of the technique and comparative determination of zinc and protein

Cited by 14 publications

References 14 publications

Determination of Zinc in Amniotic Fluid in Normal and High Risk Pregnancies

Determination of Zinc in Amniotic Fluid in Normal and High Risk Pregnancies

The concentration of the elements Zn, Cu, Mg, Fe, Na, and K in human amniotic fluid during birth

Amniotic fluid zinc in risk pregnancies

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