The relevance of TH1 and TH2 cells in immediate and nonimmediate reactions to gelatin-containing vaccine

Ohsaki, Masaya; Tsutsumi, Hiroyuki; Kumagai, Toshiko; Yamanaka, Tatsuru; Wataya, Yasuhiko; Furukawa, Hidetsugu; Kojima, Hiroyuki; Saito, Akiko; Yano, Shoki; Chiba, Shunzo

doi:10.1016/s0091-6749(99)70502-6

Cited by 22 publications

(13 citation statements)

References 28 publications

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“…Bovine gelatin can be responsible for various allergic reactions, such as those occurring after vaccinations [1, 2, 3]or after intravenous administration of liquid gelatin [11]or drugs, such as gelatin-stabilized erythropoietin [12]. It has also been established that consumption of bovine gelatin can be responsible for allergic reactions [13].…”

Section: Discussionmentioning

confidence: 99%

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Gelatin Prepared from Tuna Skin: A Risk Factor for Fish Allergy or Sensitization?

André

Cavagna

André

2003

Int Arch Allergy Immunol

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Background: Although fish gelatin may represent a useful alternative to bovine or porcine gelatins, the clearly recognized high prevalence of fish allergy could increase the risk of anaphylaxis to gelatin. The rationale for investigating tuna gelatin rather than gelatins from more allergenic fishes is the availability of an industrial gelatin under development. The infrequent occurrence of tuna allergy should influence the safety of a derived product. The present study investigated IgE antibodies to tuna-skin-derived gelatin in adults and children with documented fish allergy or sensitization. Methods: Serum samples were taken from 100 consecutive patients with fish allergy or sensitization and tested for IgE antibodies against hydrolyzed or nonhydrolyzed gelatin extracted from tuna skin as compared to extracts from tuna flesh, tuna skin as well as bovine or porcine gelatins. Patients with tuna allergies or sensitization were sensitive to the same tuna species (yellowfin) as that from which the gelatin was obtained. IgE antibodies to these various extracts were analyzed using SDS-PAGE and immunoblotting. Results: Only 3 of the 100 serum samples tested gave evidence of reactivity to gelatin extracted from tuna skin. Cross-reactivity between bovine/porcine and fish gelatins was not observed. Conclusion: The risk of adverse reactions to tuna skin gelatin seems to be significantly lower than the risk of fish allergy. Fish gelatin may represent a valuable alternative to bovine or porcine gelatins.

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Section: Discussionmentioning

confidence: 99%

“…Mammalian gelatins can cause severe anaphylactic reactions, as observed with gelatin used as a stabilizing agent in vaccines [1, 2, 3]. Bovine type I collagen is a major allergen in bovine gelatin allergy.…”

Section: Introductionmentioning

confidence: 99%

Gelatin Prepared from Tuna Skin: A Risk Factor for Fish Allergy or Sensitization?

André

Cavagna

André

2003

Int Arch Allergy Immunol

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“…9 Analysis of infiltrating cells in delayedtype hypersensitivity skin test reactions has shown the presence of both type 1 and type 2 antigen-specific T cells. [5][6][7][8][9] In addition, antigen-specific T cells that preferentially produce the type 2 cytokine IL-5 rather than the type 1 cytokine IFN-g have been noted. 8 Profiling of cytokines that may regulate such an immune response may provide data regarding immunologic function.…”

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confidence: 99%

Intracellular cytokines may model immunoregulation of abacavir hypersensitivity in HIV-infected subjects

King

Tomkins

Waters

et al. 2005

Journal of Allergy and Clinical Immunology

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“…However, an increasing number of adverse reactions in children inoculated with live attenuated virus vaccines containing gelatin have been reported [1–3]. There are further reports on the pathogenesis and primary sensitization process of this particular allergy [4–8]. Kumagai et al .…”

Section: Introductionmentioning

confidence: 99%

A Sero‐Epidemiological Survey of Gelatin Sensitization in Young Japanese Children During the 1979–1996 Period

et al. 2005

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Recently, an increasing number of adverse reactions in children inoculated with live attenuated virus vaccines containing gelatin have been reported. However, the distribution, magnitude and rate of gelatin sensitization in the Japanese population have not been established. Here, the purpose was to investigate the distribution of children with positive gelatin immunoglobulin G (IgG) and/or IgE in Japan and to ascertain whether the incidence of positive antigelatin antibody cases among the general population, as reflected in the sample employed here, has been increasing during the period in question. The presence of IgE and IgG antibodies were measured against gelatin in 1600 panel sera collected from different age groups of Japanese children in Hokkaido/Sapporo from 1979 through 1996. Among the subjects, 39 had gelatin IgG-and/or IgEpositive sera, and these were correlated with the time of obtaining the sera as well as with the age of the subjects. The older the subject and the later the period, the higher the sero-incidence. Japanese children have become increasingly sensitized to gelatin, especially since the mid-1990s.

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The relevance of TH1 and TH2 cells in immediate and nonimmediate reactions to gelatin-containing vaccine

Cited by 22 publications

References 28 publications

Gelatin Prepared from Tuna Skin: A Risk Factor for Fish Allergy or Sensitization?

Gelatin Prepared from Tuna Skin: A Risk Factor for Fish Allergy or Sensitization?

Intracellular cytokines may model immunoregulation of abacavir hypersensitivity in HIV-infected subjects

A Sero‐Epidemiological Survey of Gelatin Sensitization in Young Japanese Children During the 1979–1996 Period

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