A Sero‐Epidemiological Survey of Gelatin Sensitization in Young Japanese Children During the 1979–1996 Period

Saito, Akiko; Kumagai, Toshiko; Kojima, Hiroyuki; Terai, Itaru; Yamanaka, Tatsuru; Wataya, Yasuhiko; Umetsu, Masao; Umetsu, Aiko; Yano, Shoki

doi:10.1111/j.1365-3083.2005.01590.x

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…Egg proteins may also be present in very low amounts in some vaccines that use viruses grown in embryonated eggs, such as the influenza vaccine. These proteins may trigger an allergic response in persons intolerant to this component 31 , 32 .…”

Section: Resultsmentioning

confidence: 99%

Eventos adversos de vacinas e as consequências da não vacinação: uma análise crítica

et al. 2018

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OBJECTIVE:To analyze the risks related to vaccines and the impacts of non-vaccination on the world population.METHODS:This is a narrative review that has considered information present in the bibliographic databases NCBI-PubMed, Medline, Lilacs, and Scientific Electronic Library Online (SciELO), between November 2015 and November 2016. For the analysis of outbreaks caused by non-vaccination, we considered the work published between 2010 and 2016.RESULTS:We have described the main components of the vaccines offered by the Brazilian public health system and the adverse events associated with these elements. Except for local inflammatory reactions and rare events, such as exacerbation of autoimmune diseases and allergies, no causal relationship has been demonstrated between the administration of vaccines and autism, Alzheimer's disease, or narcolepsy. On the other hand, the lack of information and the dissemination of non-scientific information have contributed to the reemergence of infectious diseases in several countries in the world and they jeopardize global plans for the eradication of these diseases.CONCLUSIONS:The population should be well informed about the benefits of vaccination and health professionals should assume the role of disseminating truthful information with scientific support on the subject, as an ethical and professional commitment to society.

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Section: Resultsmentioning

confidence: 99%

Eventos adversos de vacinas e as consequências da não vacinação: uma análise crítica

et al. 2018

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“…Based on the information submitted on the composition of the additives containing beta-carotene the FEEDAP Panel considers it unlikely that such formulations could cause skin/eye irritancy. The FEEDAP Panel notes that a sensitisation risk associated with gelatin is reported in the scientific literature; however, such findings are restricted to its use in vaccines (Pool et al, 2002;Saito et al, 2005). Thus, the FEEDAP Panel considers it unlikely that skin sensitisation may arise in workers exposed to gelatin present in beta-carotene used as a feed additive.…”

Section: Effects On Skin and Eyesmentioning

confidence: 99%

Scientific Opinion on the safety and efficacy of beta‐carotene as a feed additive for all animal species and categories

2012

EFS2

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The use of beta‐carotene is safe for the target animals. Setting a maximum content in feed legislation is not considered necessary. However, this conclusion assumes that triphenylphosphine oxide does not exceed 100 mg/kg additive. In all food‐producing animals (except veal calves) and laboratory rodents, beta‐carotene is almost fully metabolised. In contrast, humans, non‐human primates and ferrets absorb relatively high quantities of beta‐carotene unchanged. Investigations with ferrets and hamsters as well as intervention studies in humans may indicate a certain dose‐dependent potential of beta‐carotene to promote lung carcinoma, particularly in smokers. A systematic literature review and meta‐analysis of nine randomised controlled trials demonstrated an increased risk of lung and stomach cancers in smokers and asbestos workers at dose levels ≥ 20 mg/day. However, increased risk of lung cancer at such doses could be observed only if plasma levels of beta‐carotene exceeded 3 µmol/L. The FEEDAP Panel considers it prudent, in the absence of an acceptable daily intake, that supplemental beta‐carotene in animal feed should not significantly add to consumer exposure from other sources. The use of supplemental beta‐carotene in feeds of food‐producing animals, except veal calves, would not result in a significant additional exposure of consumers to beta‐carotene; however, consumption of liver from veal calves could lead to additional exposure. Beta‐carotene is not an irritant to eyes or skin and is not a skin sensitiser. Respiratory exposure from handling beta‐carotene‐containing additives is considered potentially hazardous. Taking the widespread occurrence of beta‐carotene in nature and its oxidative susceptibility into account, the FEEDAP Panel considered it unlikely that the use of beta‐carotene in animal nutrition at the recommended feed concentrations would pose a risk to the environment. Beta‐carotene is utilised for the synthesis of retinol in almost all animal species except the cat. Effects on reproduction and immunity were not sufficiently demonstrated.

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“…Therefore, gelatin has been generally used as a stabilizer in vaccines . However, it was reported that vaccines containing gelatin sometimes cause severe anaphylactic reactions , . Beginning in 1993, anaphylactic reactions were increasingly reported after administration with gelatin-containing vaccines in Japan − .…”

Section: Introductionmentioning

confidence: 99%

A Reliable Enzyme Linked Immunosorbent Assay for the Determination of Bovine and Porcine Gelatin in Processed Foods

Doi

Watanabe

Shibata

et al. 2009

J. Agric. Food Chem.

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Since gelatin-containing foods pose a risk for eliciting allergic reactions in sensitized individuals, a novel sandwich enzyme linked-immunosorbent assay (ELISA) for the detection and quantification of bovine and porcine gelatin in processed foods was developed. Rabbits and goats were immunized with bovine gelatin, and three antisera (pAb1 and pAb2 from rabbits, and pAb3 from goats) were obtained. We established a sandwich ELISA method based on a combination of these antibodies. In this study, two sandwich ELISA methods, rabbit pAb2-pAb1 and goat pAb3-pAb3, were evaluated for sensitivity, specificity, cross-reactivity, and applicability. Both ELISA methods were highly specific for bovine and porcine gelatin but had little reactivity with fish gelatin. The detection and quantification limits for porcine gelatin were found to be 0.78 ng/mL and 1.56 ng/mL, respectively. The established sandwich ELISA methods produced no false-positives, except for heated meat products or false negatives when various commercial foods were analyzed for their gelatin content. The rabbit pAb2-pAb1 ELISA cross-reacted with boiled squid, while the goat pAb3-pAb3 ELISA did not. Thus, the proposed goat pAb3-pAb3 ELISA method is a reliable tool for the detection of gelatin contaminants present in processed foods.

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A Sero‐Epidemiological Survey of Gelatin Sensitization in Young Japanese Children During the 1979–1996 Period

Cited by 4 publications

References 14 publications

Eventos adversos de vacinas e as consequências da não vacinação: uma análise crítica

Eventos adversos de vacinas e as consequências da não vacinação: uma análise crítica

Scientific Opinion on the safety and efficacy of beta‐carotene as a feed additive for all animal species and categories

A Reliable Enzyme Linked Immunosorbent Assay for the Determination of Bovine and Porcine Gelatin in Processed Foods

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