The Relevance of Oxidative Stress Status in One Week and One Month Alcohol Abstinent Patients

Abstract

SummaryBackground: Although it is generally accepted that there is an increased oxidative stress status in alcoholics, the separate relevance of oxidative stress following alcohol withdrawal is still not understood to this date. There are reports stating that the increased oxidative stress status in alcoholics may persist independently of the constant presence of alcohol intake, while on the other side, it was demonstrated that the antioxidant defense mechanism could significantly increase after alcohol withdrawal. Methods: In the present work, we were interested in studying the relevance of oxidative stress status in the alcohol withdrawal processes, by determining some oxidative stress markers (two antioxidant enzymes: superoxide dismutase -SOD and glutathione peroxidase -GPX and a lipid peroxidation maker -MDA) after one week and one month of abstinence, as compared to the baseline and a control group of subjects. Results: Our data confirmed the increased oxidative stress status in alcoholic patients and, more importantly, we de monstrated here a significant decrease of the oxidative stress status one week and one month following the withdrawal, as showed by a significant increase in the specific activity of

The dynamics of some oxidative stress markers in 3, 6 and 12-months alcohol abstinent patients: possible relevance for the usage of antioxidants in alcohol withdrawal / Dinamica unor markeri ai stresului oxidativ la 3, 6 şi 12 luni de abstinenţă de la alcool: posibila relevanţă a utilizării de antioxidanţi

“…In this way, we generally demonstrated the fact that a decrease of the oxidative stress level is sustained by all measured parameters both on short term (9) and long term, as demonstrated through the results of the present report.…”

“…Still, in the case of all three markers of the oxidative stress status which we determined back then, the levels from one week or one month of abstinence were significantly altered when compared to controls, suggesting that severe and prolonged deficiency in their levels needs longer than one month of abstinence to normalize (9).…”

“…However, as we showed back then, in the case of all three markers of oxidative stress status which we determined (SOD, GPX and MDA), the levels after one week or one month of abstinence were significantly altered when compared to controls (9).…”

Minireview on the Connections between the Neuropsychiatric and Dental Disorders: Current Perspectives and the Possible Relevance of Oxidative Stress and Other Factors

“…Dental disorders have a multifactorial origin, being correlated with an umbrella of risk factors and disorders going from the existence of transmitters in the teeth, oral infestation by insects or worms [ 1 ], feeling that the upper part of the mouth is pushing to the brains (press case report by our group) to the faulty personal hygiene in dementia [ 2 ], schizophrenia [ 3 ] or mental retardation [ 4 ], and peaking with the removal of all healthy teeth, e.g., in schizophrenia, in just 6 months and refusal of prosthodontic treatment [ 5 ]. Risk factors for a bereft dental hygiene even in healthy patients with an otherwise healthy oral state are vitamin B deficits related to alcohol abuse [ 6 ], considering that alcohol and drug consumption is toxic per se for teeth, and perhaps oxidative stress implications in this context [ 7 , 8 ], as well as the lack of an appropriate and equilibrated diet.…”