The relevance of Candida spp. in chronic periodontal disease

Razina, I. N.; Chesnokova, M. G.; Недосеко, В. Б.

doi:10.17116/stomat20179644-6

Cited by 6 publications

(8 citation statements)

References 5 publications

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“…Examination data from patients with systemic pathology were not included. Periodontal pocket or gingival sulcus samples were collected either by a paper point (paper point size and time in the periodontal pocket/gingival sulcus varied) (Brusca et al, 2014 ; Camargo, Silva, et al, 2016 ; Canabarro et al, 2013 ; De‐La‐Torre et al, 2018 ; Gomes et al, 2017 ; Grigoryan et al, 2019 ; Matić Petrović et al, 2015 , 2019 ; McManus et al, 2012 ; Melekhov et al, 2013 ; Mirsaeva et al, 2018 ; Rams et al, 2014 ; Razina et al, 2017 ; Risovannaya & Lalieva, 2019 ; Sanz‐Sánchez et al, 2016 ; Tsarev et al, 2012 ; Volchenkova et al, 2017 ), or a sterile curette (Camargo, Abreu, et al, 2016 ; Chumakova et al, 2012 ; Joshi et al, 2012 ; Krishnan et al, 2020 ; Matić Petrović et al, 2015 , 2019 ; McManus et al, 2012 ; Sardi, Almeida, et al, 2011 ; Sasikumar et al, 2017 ; Colombo et al, 2016 ). In three studies (Matić Petrović et al, 2015 , 2019 ; McManus et al, 2012 ), the samples were obtained by both paper points and sterile curettes.…”

Section: Resultsmentioning

confidence: 99%

“…Candida spp. were identified using a culture method (Brusca et al, 2014 ; Canabarro et al, 2013 ; Chumakova et al, 2012 ; Joshi et al, 2012 ; Komleva et al, 2010 ; Krishnan et al, 2020 ; Matić Petrović et al, 2015 , 2019 ; Melekhov et al, 2013 ; Rams et al, 2014 ; Razina et al, 2017 ; Risovannaya & Lalieva, 2019 ; Sanz‐Sánchez et al, 2016 ; Sasikumar et al, 2017 ; Volchenkova et al, 2017 ), PCR (Camargo, Abreu, et al, 2016 ; Camargo, Silva, et al, 2016 ; Sardi, Duque, Höfling, et al, 2012 ), real‐time PCR (Grigoryan et al, 2019 ), a combination of culture and PCR (De‐La‐Torre et al, 2018 ; Gomes et al, 2017 ; McManus et al, 2012 ; Mirsaeva et al, 2018 ; Tsarev et al, 2012 ), or checkerboard DNA−DNA hybridization technique (Colombo et al, 2016 ). One study did not indicate the identification method (Tokmakova et al, 2014 ).…”

Section: Resultsmentioning

confidence: 99%

“…Besides periodontal pathogens, dental plaque contains other bacteria as well as fungi and viruses whose role is actively studied. Many researchers consider that yeast‐like fungi, specifically Candida spp., are one of the important causes of the development, progression, and complicated course of CP (Canabarro et al, 2013 ; Razina et al, 2017 ; Sardi, Duque, Mariano, et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

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Candida species detection in patients with chronic periodontitis: A systematic review and meta‐analysis

Slazhneva

Tikhomirova

Царев

et al. 2022

Clinical & Exp Dental Res

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Objectives: To assess the Candida species occurrence rate and concentration in periodontal pockets in chronic periodontitis (CP) by meta-analysis. Materials and Methods:A search was performed of articles published between January 1, 2010, and October 1, 2020, in English and in Russian, in the electronic databases MEDLINE-PubMed, Google Scholar, The Cochrane Library, ClinicalTrials.gov, Research Gate, eLIBRARY, and Cyberleninka (PROSPEROCRD42021234831). The odds ratio (OR), standardized mean difference (SMD), and 95% confidence interval (CI) were calculated using Review Manager 5.4.1 to compare the risk of CP when Candida spp.were detected in the gingival sulcus or periodontal pocket and to compare Candida spp. density counts in patients with CP and periodontally healthy patients.Results: Twenty-six studies were included in the systematic review and 11 were included in the meta-analysis. The results showed that Candida spp. may increase the chance of CP development by 1.76 times (OR = 1.76; 95% CI = 1.04-2.99; Z = 2.10; p = .04; I 2 = 61%). More Candida spp. were found in patients with CP than in periodontally healthy patients (SMD = 1.58; 95% CI = 0.15−3.02; p = .03; I 2 = 98%).No data were found relating to the statistically significant influence of Candida glabrata, Candida krusei and Candida tropicalis on CP development. Conclusion:We found that Candida albicans insignificantly increased the risk of CP development but, due to the heterogeneity of the included studies, further research is necessary to determine the exact role of Candida spp. in the development and course of the inflammatory periodontal diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Candida species detection in patients with chronic periodontitis: A systematic review and meta‐analysis

Slazhneva

Tikhomirova

Царев

et al. 2022

Clinical & Exp Dental Res

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“…Candida albicans (C. albicans) is the main species responsible for causing oral candidiasis [5]. It has the ability to grow in anaerobiosis and has a role in endodontic and periodontal infections [6,7]. Besides, Candida tropicalis (C. tropicalis), the yeast that has a high capacity for adhesion and biofilm formation, has a role in fungal infections [8].…”

Section: Introductionmentioning

confidence: 99%

Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo

Meccatti

Moura

Pinto

et al. 2022

International Journal of Dentistry

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Radiotherapy induces a higher level of Candida spp. colonization, resulting in oral candidiasis. This study aimed to evaluate the phototransformation potential of the glycolic extract of Curcuma longa (C. longa); the antifungal activity of C. longa, curcumin, and antifungal photodynamic therapy (aPDT) with blue light-emitting diodes “LED” on Candida albicans and Candida tropicalis in vitro; and the toxicity of C. longa and curcumin in Galleria mellonella model. In order to confirm the light absorption capacity of the C. longa extract, its phototransformation potential was evaluated. The antifungal effect of C. longa, curcumin, and aPDT was evaluated over Candida spp. Finally, the toxicity of C. longa and curcumin was evaluated on the Galleria mellonella model. The data were analyzed using the GraphPad Prism 5.0 software considering α = 5%. It was found that C. longa, curcumin, and aPDT using blue LED have an antifungal effect over C. albicans and C. tropicalis. The extract of C. longa 100 mg/mL and curcumin 200 μg/mL do not show toxicity on Galleria mellonella model.

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“…It is the main species responsible for causing oral candidosis. It can grow in anaerobiosis, being able to contribute to periodontal and endodontic infections (Bernal-Treviño et al, 2018;Razina et al, 2017). Enterococcus faecalis is an optional anaerobic bacterium that can invade dentinal tubules, initiate biofilm, and is associated with secondary endodontic infections (Tennert, Fuhrmann, Wittmer, Karygianni, Altenburger, Pelz, 2014;Wilson et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Effect of Stryphnodendron adstringens (Mart.) Coville extract in aerobic and anaerobic microorganisms and mammalian cells

Sper¹,

Amêndola²,

Ramos³

et al. 2021

RSD

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Stryphnodendron adstringens (Mart.) Coville is a medicinal plant known for its anti-inflammatory and antimicrobial properties. This study evaluated some biological activities of extract from S. adstringens. Antimicrobial activity was checked in planktonic cultures and monomicrobial biofilms on aerobic, and anaerobic dental microorganisms. Analyzes of cytotoxicity using MTT assay, and genotoxicity by micronucleus test were performed in human keratinocytes (HACAT), murine macrophages (RAW 264.7), and murine fibroblasts (L929). The anti-inflammatory effect was checked in RAW 264.7 stimulated by lipopolysaccharide (LPS) from Escherichia coli, and treated with the plant extract. The levels of cytokines, and nitric oxide (NO) were measured by ELISA, and Griess method, respectively. Data were analyzed by ANOVA, followed by Tukey's, or Kruskal-Wallis, and Dunns tests (P ≤ 0.05). Biofilms of anaerobic bacteria were very susceptible to the plant extract. Effective concentrations showed cell viability > 50%, except 25 mg/mL for HACAT after 24 h of exposure. The extract of S. adstringens was not genotoxic for RAW 264.7. LPS associated with extract increased the production of all cytokines, except TNF-α. However, the plant extract decreased the production of NO. In conclusion, the extract of S. adstringens affected biofilm of anaerobic bacteria using non-cytotoxic concentrations for RAW 264.7, L929, and HACAT cells.

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The relevance of Candida spp. in chronic periodontal disease

Cited by 6 publications

References 5 publications

Candida species detection in patients with chronic periodontitis: A systematic review and meta‐analysis

Candida species detection in patients with chronic periodontitis: A systematic review and meta‐analysis

Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo

Effect of Stryphnodendron adstringens (Mart.) Coville extract in aerobic and anaerobic microorganisms and mammalian cells

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