The Release of Perillyl Alcohol from the Different Kind of Vehicles

Miastkowska, Małgorzata; Konieczna, Monika; Lasoń, Elwira; Tabaszewska, Małgorzata; Sikora, Elżbieta; Ogonowski, Jan

doi:10.2174/1389201019666180730165330

Cited by 7 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study of the release of a monoterpene-loaded nanoemulsion was described in our previous study [21]. As we mentioned before, the concentration of perillyl alcohol (PA), forskolin (F) and ursolic acid (UA) in the final formulation was related to their maximum solubility in surfactant:oil mixture and reached 0.5%, 0.075% and 0.05% w/w, respectively.…”

Section: Release Of Terpenoidsmentioning

confidence: 89%

“…In recent years, most studies have focused on the release of one drug from different formulations to select the most effective medium [21][22][23][24][25][26][27]. Here, we have decided to analyze the effect of the drug structure on the release from the same carrier as there is little information concerning that topic.…”

Section: Release Of Terpenesmentioning

confidence: 99%

“…The preparation and characteristics of the nanoemulsion with perillyl alcohol (PA) were described in our previous study [21]. The formulation with forskolin (F) and ursolic acid (UA) was obtained in a similar way.…”

Section: Nanoemulsion Preparation and Characterizationmentioning

confidence: 99%

“…The release kinetics was determined by linear regression analysis of the in vitro release curves in four models: zero order (cumulative amount (%) of drug released with time), first-order (log cumulative amount (%) of drug released with time), Higuchi (cumulative amount (%) of drug released with the square root of time), and Korsemeyer-Peppas (log cumulative amount (%) of drug released with log time). The mathematical model that best expressed the kinetic release profile was selected on the basis of the highest coefficient of determination (R 2 ) [21][22][23]42,43].…”

Section: Evaluation Of Release Kineticsmentioning

confidence: 99%

See 3 more Smart Citations

Influence of Terpene Type on the Release from an O/W Nanoemulsion: Experimental and Theoretical Studies

Miastkowska

Śliwa

2020

Molecules

View full text Add to dashboard Cite

The interaction between a drug molecule and its carrier’s components is an important factor which influences the drug release profile. For this purpose, molecular dynamics (MD) may be the in silico tool which can help to understand the mechanism of drug loading/release. The aim of this work is to explain the effect of interactions between different types of terpenes, namely perillyl alcohol, forskolin, ursolic acid, and the nanoemulsion droplet core, on the release by means of experimental and theoretical studies. The basic nanoemulsion was composed of caprylic/capric triglyceride as the oil phase, polysorbate 80 as the emulsifier, and water. The in vitro release tests from a terpene-loaded nanoemulsion were carried out to determine the release profiles. The behavior of terpenoids in the nanoemulsion was also theoretically investigated using the molecular dynamics method. The forskolin-loaded nanoemulsion showed the highest percentage of drug release (almost 80% w/w) in contrast to ursolic acid and perillyl alcohol-loaded nanoemulsions (about 53% w/w and 19% w/w, respectively). The results confirmed that the kinetic model of release was terpene-type dependent. The zero-order model was the best to describe the ursolic acid release profile, while the forskolin and the perillyl alcohol followed a first-order and Higuchi model, respectively. Molecular dynamics simulations, especially energetical analysis, confirmed that the driving force of terpenes diffusion from nanoemulsion interior was their interaction energy with a surfactant.

show abstract

Section: Release Of Terpenoidsmentioning

confidence: 89%

Section: Release Of Terpenesmentioning

confidence: 99%

Section: Nanoemulsion Preparation and Characterizationmentioning

confidence: 99%

Section: Evaluation Of Release Kineticsmentioning

confidence: 99%

See 2 more Smart Citations

Influence of Terpene Type on the Release from an O/W Nanoemulsion: Experimental and Theoretical Studies

Miastkowska

Śliwa

2020

Molecules

View full text Add to dashboard Cite

show abstract

“…Their polar nature results in their unique properties such as: spreadability, skin feel, emollience, and hydration. [50,51] Spreadability is closely related to the properties of the oils, such as their state, surface tension, viscosity, and wetting angle. [12] The tested vegetable oils were liquids with various viscosities.…”

Section: Characterization Of the Vegetable Oilsmentioning

confidence: 99%

Effectiveness of Protective Preparations: Impact of Vegetable Oil Additives to Recipes

Kulawik‐Pióro

Klimaszewska

Ogorzałek

et al. 2020

Euro J Lipid Sci & Tech

View full text Add to dashboard Cite

The aim of the study is to demonstrate the effect of the addition of vegetable oils rich in EFA on the effectiveness of hydrophobic skin protection preparations intended for work in the wet environment. The research hypothesis assumes that the increase in the concentration of vegetable oils in the formula of protective preparations improves their spreadability on the skin, thus translating into acceptance of the preparations by users, improving their quality of life, strengthening the barrier functions of the skin without reducing the effectiveness of the protective action. The distribution capacity of pure vegetable oils is determined using instrumental analysis and sensory analysis. Also, TEWL tests are used to evaluate their occlusal properties. For protective preparations based on them, the distribution capacity is tested by in vitro methods as well as in vivo tests and sensory analyses are performed. The effectiveness of the tested preparations is measured by tests concerning absorbability, occlusion capacity and washability. The results are analyzed and compared, and a correlation matrix is developed to establish the relationship between sensory and instrumental measurements. The effectiveness of the preparations depends on the type of oil (its spreadability and viscosity) and the amount in the formulation. Practical Applications: For hydrophobic preparations of ointment type, there is a possibility to implement such instrumental techniques as: determination of preparation consistency by means of a cone, ability to distribute by means of parallel plates, but also determination of preparation viscosity by rheological methods. Viscosity, spreading ability, and oil occlusion ability are the most important parameters that should be taken into account when we design hydrophobic skin protection preparations intended for the works in the wet environment.

show abstract

Bioactive Lavandula angustifolia essential oil-loaded nanoemulsion dressing for burn wound healing. In vitro and in vivo studies

Miastkowska

Sikora

Kulawik‐Pióro

et al. 2023

Biomaterials Advances

View full text Add to dashboard Cite

The Release of Perillyl Alcohol from the Different Kind of Vehicles

Cited by 7 publications

References 0 publications

Influence of Terpene Type on the Release from an O/W Nanoemulsion: Experimental and Theoretical Studies

Influence of Terpene Type on the Release from an O/W Nanoemulsion: Experimental and Theoretical Studies

Effectiveness of Protective Preparations: Impact of Vegetable Oil Additives to Recipes

Bioactive Lavandula angustifolia essential oil-loaded nanoemulsion dressing for burn wound healing. In vitro and in vivo studies

Contact Info

Product

Resources

About