Influence of Terpene Type on the Release from an O/W Nanoemulsion: Experimental and Theoretical Studies

Miastkowska, Małgorzata; Śliwa, Paweł

doi:10.3390/molecules25122747

Cited by 25 publications

(24 citation statements)

References 42 publications

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“…However, the release kinetics of encapsulated active compounds in an aqueous solution is dependent on many factors. The physical and chemical properties of the encapsulated compounds, such as the concentration, solubility, vapor pressure and the octanol-water partition coefficient (K ow ) are of importance, in combination with the properties of the nanocarrier [56]. Thus, the release into liquid media depends largely on the experimental setup.…”

Section: Stimuli-activated Release Of the Active Compoundsmentioning

confidence: 99%

Controlled Release of Volatile Antimicrobial Compounds from Mesoporous Silica Nanocarriers for Active Food Packaging Applications

Gulin-Sarfraz

Kalantzopoulos

Haugen

et al. 2022

IJMS

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Essential oils and their active components have been extensively reported in the literature for their efficient antimicrobial, antioxidant and antifungal properties. However, the sensitivity of these volatile compounds towards heat, oxygen and light limits their usage in real food packaging applications. The encapsulation of these compounds into inorganic nanocarriers, such as nanoclays, has been shown to prolong the release and protect the compounds from harsh processing conditions. Nevertheless, these systems have limited shelf stability, and the release is of limited control. Thus, this study presents a mesoporous silica nanocarrier with a high surface area and well-ordered protective pore structure for loading large amounts of natural active compounds (up to 500 mg/g). The presented loaded nanocarriers are shelf-stable with a very slow initial release which levels out at 50% retention of the encapsulated compounds after 2 months. By the addition of simulated drip-loss from chicken, the release of the compounds is activated and gives an antimicrobial effect, which is demonstrated on the foodborne spoilage bacteria Brochothrix thermosphacta and the potentially pathogenic bacteria Escherichia coli. When the release of the active compounds is activated, a ≥ 4-log reduction in the growth of B. thermosphacta and a 2-log reduction of E. coli is obtained, after only one hour of incubation. During the same one-hour incubation period the dry nanocarriers gave a negligible inhibitory effect. By using the proposed nanocarrier system, which is activated by the food product itself, increased availability of the natural antimicrobial compounds is expected, with a subsequent controlled antimicrobial effect.

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Section: Stimuli-activated Release Of the Active Compoundsmentioning

confidence: 99%

Controlled Release of Volatile Antimicrobial Compounds from Mesoporous Silica Nanocarriers for Active Food Packaging Applications

Gulin-Sarfraz

Kalantzopoulos

Haugen

et al. 2022

IJMS

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“…However, those with uniformly loaded drugs could provide a sustained drug release over time. In addition, small particle sizes usually offer a larger surface-to-volume ratio, which pushes the rapid release [ 39 ]. This can confirm that the mean droplet size of the NE system plays a determinant role in the in vitro drug release, irrespective of the percentage (%) compositions of the NE system.…”

Section: Resultsmentioning

confidence: 99%

“…Further, the presence of Tween 40 in the S mix when developing NE systems as a surfactant can enhance the dermal delivery of drugs, which might have helped in the enhanced skin-penetration of TAM from newly developed TAM-NEGs compared to plain gel [ 46 ]. Tweens are capable of altering the skin barriers by inserting them within the skin stratum corneum and creating a strong interaction with water content, which can disturb the skin’s lipid and protein permeability, whereby the skin deposition and permeation for the loaded drug is improved [ 39 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

Tamoxifen Citrate Containing Topical Nanoemulgel Prepared by Ultrasonication Technique: Formulation Design and In Vitro Evaluation

Alyami

Alshehri

et al. 2022

Gels

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The present study aims to design and develop a nanoemulgel formulation of Tamoxifen citrate (TAM), a water-insoluble, potent anticancer drug, using the spontaneous emulsification method to improve topical delivery, achieve high accumulation at the tumour site, and spare the healthy tissues. The oil-based selection was related to the TAM solubility, while the surfactant and co-surfactant were chosen based on the droplets’ thermodynamic stability and size. Afterwards, a pseudo-ternary phase diagram was built for the most promising formulation using two oils, olive and sesame, with a varied mix of Tween 40 as the surfactant and Trascutol HP as the co-surfactant (Smix), by the optimisation of experiments. The nanoemulsion (NE) formulations that were prepared were found to have an average droplet size of 41.77 ± 1.23 nm and 188.37 ± 3.53 nm, with suitable thermodynamic stability and physicochemical properties. Both olive and sesame oils are natural food additives due to their associated antioxidant effects; therefore, they showed no toxicity profile on breast cell lines (MCF-7, ATCC number HTB-22). The TAM-NE preparations revealed a prolonged and doublings superior cumulative percentage of in vitro release of TAM compared to TAM plain gel suspension over 24 h. The release data suggested that the Higuchi model was the best fitting kinetical model for the developed formulations of NE1, NE9, and NE18. The extended release of the drug as well as an acceptable amount of the drug permeated TAM via nanogel preparations suggested that nanoemulgel (NEG) is suitable for the topical delivery of TAM in breast cancer management. Thus, this work suggests that a nanogel of TAM can improve anticancer properties and reduce systemic adverse effects compared to a suspension preparation of TAM when applied in the treatment of breast cancer.

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“… Miastkowska and Śliwa (2020) designed and successfully synthesized a UA nanoemulsion with a particle size of 248 ± 15 nm, but no tests related to biological activity have been conducted. Alvarado et al, successfully prepared a UA-containing nanoemulsion, which exhibited strong proliferation inhibition against B16 melanoma cell lines (the IC 50 was between 0.58 and 2.9 µM).…”

Section: Review Of Ua Nanoformulationsmentioning

confidence: 99%

Nanoformulations of Ursolic Acid: A Modern Natural Anticancer Molecule

et al. 2021

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Background: Ursolic acid (UA) is a natural pentacyclic triterpene derived from fruit, herb, and other plants. UA can act on molecular targets of various signaling pathways, inhibit the growth of cancer cells, promote cycle stagnation, and induce apoptosis, thereby exerting anticancer activity. However, its poor water-solubility, low intestinal mucosal absorption, and low bioavailability restrict its clinical application. In order to overcome these deficiencies, nanotechnology, has been applied to the pharmacological study of UA.Objective: In this review, we focused on the absorption, distribution, and elimination pharmacokinetics of UA in vivo, as well as on the research progress in various UA nanoformulations, in the hope of providing reference information for the research on the anticancer activity of UA.Methods: Relevant research articles on Pubmed and Web of Science in recent years were searched selectively by using the keywords and subheadings, and were summarized systematically.Key finding: The improvement of the antitumor ability of the UA nanoformulations is mainly due to the improvement of the bioavailability and the enhancement of the targeting ability of the UA molecules. UA nanoformulations can even be combined with computational imaging technology for monitoring or diagnosis.Conclusion: Currently, a variety of UA nanoformulations, such as micelles, liposomes, and nanoparticles, which can increase the solubility and bioactivity of UA, while promoting the accumulation of UA in tumor tissues, have been prepared. Although the research of UA in the nanofield has made great progress, there is still a long way to go before the clinical application of UA nanoformulations.

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Influence of Terpene Type on the Release from an O/W Nanoemulsion: Experimental and Theoretical Studies

Cited by 25 publications

References 42 publications

Controlled Release of Volatile Antimicrobial Compounds from Mesoporous Silica Nanocarriers for Active Food Packaging Applications

Controlled Release of Volatile Antimicrobial Compounds from Mesoporous Silica Nanocarriers for Active Food Packaging Applications

Tamoxifen Citrate Containing Topical Nanoemulgel Prepared by Ultrasonication Technique: Formulation Design and In Vitro Evaluation

Nanoformulations of Ursolic Acid: A Modern Natural Anticancer Molecule

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