The Release of Guinea Pig Liver Histaminase and Some of Its Properties

Metabolic Fate of Plasma Diamine Oxidase: Evidence of Isolated and Perfused Rat Liver Uptake

“…In fact, heparin does not promote the release of intracellular DAO from isolated rat enterocytes in the incuba tion medium, while heparin injected into the superior mesenteric artery promotes a marked increase in DAO activity in the supe rior mesenteric vein [12]. A curious related fact is that in guinea pigs the liver is thought to be a major source of DAO which can be released by perfused heparin [26]. In the present study the DAO plasmatic curves of subjects submitted to a high dose of heparin suggest that heparin acts as contin uous stimulus of enzyme release, mainly from intestinal stores, as indicated by a very low DAO response in subjects with small intestinal mucosa atrophy [8].…”

Blood and Tissue Histamine during <i>in vivo </i>Anaphylactic Shock in Susceptible and Nonsusceptible Guinea Pigs

“…G iertz and Ernenputsch [7] have recently shown that most of the histaminase released after shock in the guinea pig comes from the liver. Schmutzler et al [15] maintained that the released histaminase has little influence on the development of anaphylactic shock in the guinea pig, despite its very rapid release [12]. A significant decrease of lung histamine after shock was noted in only two animals, one of colony M and one of strain 2.…”

Zur Genese atraumatischer Leberblutungen

“…die ffir die Immun-Forschung wichtige Eigenschaft, aus Hepatocyten Histaminase (Diaminooxidase) freizusetzen. Sie ist experimentell durch Aminoguanidine zu blockieren (Gross et al 1952;Schuler 1952;Kobinger und Friis 1961;Lorenz et al 1967;Hahn und Schmutzler 1967;Giertz et al 1967;Schmutzler 1968;Schmutzler et al 1969;Schmutzler et al 1974). Heparin befindet sich in d e n Granula der Mastzellen der basophilen und eosinophilen Leukozyten in komplex gebundener Form.…”