The release and fate of vaso‐active hormones in the circulation

Vane, John R.

doi:10.1111/j.1476-5381.1969.tb07982.x

Cited by 641 publications

(258 citation statements)

References 141 publications

Supporting

Mentioning

248

Contrasting

Unclassified

Order By: Relevance

“…Thus, the pressor potency was reduced by treatment with the catecholamine depleting substances, reserpine and syrosingopine, and was restored by infusions of catecholamines. Similarly, inhibition of monoamine oxidase which has been shown to increase peripheral levels of catecholamines (Goldberg & Shideman, 1962;Sanan & Vogt, 1962) (Feldberg & Lewis, 1964, 1965Vane, 1969 (Bickerton & Buckley, 1961) and via central vagal inhibition (Scroop & Lowe, 1968). The failure of both pempidine and bethanidine to reduce the angiotensin pressor responses in the present experiments argues against a significant central component to the response.…”

contrasting

confidence: 38%

Role of noradrenaline in the acute pressor response to angiotensin in conscious cats

Day¹,

Owen²

1970

British J Pharmacology

View full text Add to dashboard Cite

contrasting

confidence: 38%

Role of noradrenaline in the acute pressor response to angiotensin in conscious cats

Day¹,

Owen²

1970

British J Pharmacology

View full text Add to dashboard Cite

“…This inhibitor specificity may explain the conflict between the results of Udenfriend, Weissbach & Bogdansky (1957), who could not affect 5-HT metabolism in the whole mouse with iproniazid, and those of Axelrod & Inscoe (1963) and of Gershon & Ross (1966a) who demonstrated an inhibition of 5-HT metabolism in the mouse using another MAO inhibitor, JB 516. These last authors have also shown that the radioactivity in mouse lung derived either from "4C-5-HTP (Gershon & Ross, 1966b) or from '4C-5-HT (personal communication to J. R. Vane quoted in Vane, 1969) is mainly in septal cells which could be either alveolar macrophages (as they suggest) or Type II alveolar cells (Heinemann & Fishman, 1969). Either these septal cells or the endothelial cells lining the lung capillaries (Hughes et al, 1969) would be readily accessible to amines in the capillaries, but neither contain granules of the type generally associated with binding of biogenic amines.…”

Section: Discussionmentioning

confidence: 99%

“…The lung has been shown to play an important part in the metabolism of several vaso-active hormones (Vane, 1969). 5-Hydroxytryptamine (5-HT) is removed from the circulation by the lungs of the anaesthetized dog (Davies & Wang, 1965;Thomas & Vane, 1967), and isolated cat's lung perfused with blood also removed 5-HT (Gaddum, Hebb, Silver & Swan, 1953).…”

Section: Introductionmentioning

confidence: 99%

Removal of 5‐hydroxytryptamine in the pulmonary circulation of rat isolated lungs

Alabaster

Bakhle

1970

British J Pharmacology

144

View full text Add to dashboard Cite

. Rat isolated lungs perfused via the pulmonary artery with Krebs solution removed 92% of the 5‐hydroxytryptamine (5‐HT) infused through it. This degree of removal was independent of concentration in the range from 5 to 100 g/ml. . The removal of 5‐HT by the lungs was inhibited by amitriptyline and desmethylimipramine (10−6–10−5m). . The monoamine oxidase inhibitors, mebanazine and iproniazid (10−6–10−5m), inhibited the initial removal slightly, but their main effect was to preserve the 5‐HT taken up and this 5‐HT slowly reappeared in the effluent from the lungs. Tranylcypromine (5 × 10−7–10−6m) showed a combination of amitriptyline‐like and mebanazine‐like effects on the 5‐HT removal in rat lung. . Experiments with 3H‐5‐HT showed that although under normal conditions only 10% of the radioactivity appeared in the lung effluent as 5‐HT within the first 5 min, the rest of radioactivity administered could be recovered in the effluent over 50 min as a metabolite, probably 5‐hydroxyindoleacetic acid. . The following amines were without effect on the removal of 5‐HT by rat lungs: noradrenaline (6 × 10−7m), normetanephrine (5 × 10−6m), metaraminol (10−6m), reserpine (10−6–10−5m) and phenoxybenzamine (10−5m). . We conclude that the removal of 5‐HT by rat lungs involves a process of uptake and metabolism rather than one of uptake and storage, but this process is not the catecholamine Uptake2. The cells involved in this process might be either capillary endothelial cells or septal cells.

show abstract

“…The blood-bathed organ technique (Vane, 1964(Vane, , 1969 was used to measure release of prostaglandin-like material from dog spleen in vivo. Seventeen dogs of either sex weighing 11 5-24 kg were anaesthetized with pentobarbitone sodium (30 mg/kg intravenously).…”

Section: Blood-bathed Organ Experimentsmentioning

confidence: 99%

Prostaglandins and the mechanism of analgesia produced by aspirin‐like drugs

Ferreira

Moncada

Vane

1973

British J Pharmacology

Self Cite

311

View full text Add to dashboard Cite

Summary1. Resting splenic venous outflow from anaesthetized dogs contains prostaglandin-like material: the concentration increases after intra-arterial injections of bradykinin into the spleen, and is abolished by treatment with indomethacin. 2. Intra-arterial injections of bradykinin into the spleen of lightly anaesthetized dogs elicit a dose-dependent reflex increase in the blood pressure, which is reduced but not abolished by treatment with indomethacin. 3. Addition of prostaglandin E1 or E2 either by injections or by infusions restores the reflex increase in the blood pressure due to bradykinin injections after indomethacin treatment. 4. The sensitizing action of endogenously released prostaglandins at or near the afferent nerve endings is discussed. 5. The analgesic activity of aspirin-like drugs is explained in terms of the removal of the sensitizing activity of prostaglandins.

show abstract

The release and fate of vaso‐active hormones in the circulation

Cited by 641 publications

References 141 publications

Role of noradrenaline in the acute pressor response to angiotensin in conscious cats

Role of noradrenaline in the acute pressor response to angiotensin in conscious cats

Removal of 5‐hydroxytryptamine in the pulmonary circulation of rat isolated lungs

Prostaglandins and the mechanism of analgesia produced by aspirin‐like drugs

Contact Info

Product

Resources

About