Role of noradrenaline in the acute pressor response to angiotensin in conscious cats

Day, Michael; Owen, David A.

doi:10.1111/j.1476-5381.1970.tb10664.x

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…The response to All following phentolamine was augmented as has been found previously (Day & Owen, 1970). The response to octadecyl-AGPC after phentolamine administration was significantly reduced, from which it can be inferred that a portion of the octadecyl-AGPC vasodilator response in untreated animals may be due to an action on the o.-adrenoceptor.…”

Section: Discussionsupporting

confidence: 81%

Evidence for the lack of interaction between (±)‐ 1‐O‐octadecyl‐2‐acetylglyceryl‐3‐phosphorylcholine and α‐adrenoceptors in vivo and in vitro

Cervoni¹,

Goldstein²,

Herzlinger³

et al. 1984

British J Pharmacology

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1 The interactions of (±)-1-O-octadecyl-2-acetylglyceryl-3-phosphorylcholine (octadecyl-AGPC) with a-adrenoceptors were studied in rat mesenteric artery, cat nictitating membrane and on the blood pressure of the cat and spontaneously hypertensive (SH) rat (MABP). After an intravenous dose of phentolamine which lowered MABP, the depressor response to octadecyl-AGPC was reduced. When MABP in the phentolamine-treated SH rat was restored to its initial level with an infusion of angiotensin II (All), the depressor response to octadecyl-AGPC was restored to its original magnitude. The effectiveness of oc-adrenoceptor blockade under these experimental conditions was monitored with intravenous NA and Ad. 5 Thus, based on radioligand binding studies and pharmacological studies, it is concluded that octadecyl-AGPC lacks the ability to interact with cx-adrenoceptors.

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Section: Discussionsupporting

confidence: 81%