The Relative Biological Effect of High-Z, High-LET Charged Particles for Spermatogonial Killing

Alpen, Edward L.; Powers-Risius, P.

doi:10.2307/3575758

Cited by 72 publications

(32 citation statements)

References 15 publications

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“…The high-LET 40 Ar ions appeared to induce the most severe damage, and 60 co-y rays induced the least. Based on cell killing~ itro and ~ vivo, dose and dose averaged LET alone are not sufficient to characterize or predict RBE (25,26). Particle mass, charge or velocity influence cell killing and the extent to which these factors are also important for characterization of late effects of charged particles remains to be determined.…”

Section: Resultsmentioning

confidence: 99%

“…At the 10% survival level, the RBE is close to 1.0 for CFU-S harvested from mice exposed to 40 Ar particle at the same particle residual range used in the present studies (27). Likewise, based on 0 0 for either intestinal microcolonies or testis weight loss, the RBE for 40 Ar particles is maximum in the plateau portion of the Bragg curve where the LET is -100 KeV/~m, and declines with decreasing residual range (and increasing LET) in 4-cm spread Bragg peaks (20,26). Other emerging results on Harderian gland carcinogenesis following exposure to heavy charged particles show even a higher RBE at 500-700 KeV/~m than at 80-150 KeV/~m.…”

Section: Resultsmentioning

confidence: 99%

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Late Effects of Heavy Charged Particles on the Fine Structure of the Mouse Coronary Artery

Yang¹,

Ainsworth²

1982

Radiation Research

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Late Effects of Heavy Charged Particles on the Fine Structure of the Mouse Coronary Artery

Yang¹,

Ainsworth²

1982

Radiation Research

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“…(1) (2) where f is the fraction of initially injected radioactivity remaining in the testis and t is the time after injection in hours.…”

Section: Clearance Of the Radionuclides From The Testismentioning

confidence: 99%

Relative Biological Effectiveness of Alpha-Particle Emitters In Vivo at Low Doses

Howell¹,

Azure²,

Narra³

et al. 1994

Radiation Research

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The therapeutic potential of radionuclides that emit α particles, as well as their associated health hazards, have attracted considerable attention. The 224 Ra daughters 212 Pb and 212 Bi, by virtue of their radiation properties which involve emission of α and β particles in their decay to stable 208 Pb, have been proposed as candidates for radioimmunotherapy. Using mouse testes as the experimental model and testicular spermhead survival as the biological end point, the present work examines the radiotoxicity of 212 Pb and its daughters. When 212 Pb, in equilibrium with its daughters 212 Bi, 212 Po and 208 Tl, was administered directly into the testis, the dose required to achieve 37% survival (D 37 ) was 0.143 ± 0.014 Gy and the corresponding RBE of the mixed radiation field was 4.7 when compared to the D 37 for acute external 120 kVp X rays. This datum, in conjunction with our earlier results for 210 Po, was used to obtain an RBE-LET relationship for α particles emitted by tissue-incorporated radionuclides: RBE α = 4.8 − 6.1 × 10 −2 LET + 1.0 × 10 −3 LET 2 . Similarly, the dependence of RBE on α-particle energy E α was given by . These relationships, based on in vivo experimental data, may be valuable in predicting biological effects of α-particle emitters.

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“…Risk estimate also demands that different heavy ion species be used at different energies for RBE determination and to study the RBE-LET relationship. Importantly, the RBE-LET relation of heavy ion radiation is dependent not only on the particle energy but also on the Z-value of the particle [10]. Furthermore, RBE differs with the biological endpoints and tissue/cell types under investigation.…”

Section: Introductionmentioning

confidence: 99%

Relative biological effectiveness of 12C and 28Si radiation in C57BL/6J mice

Suman

Datta

Trani

et al. 2012

Radiat Environ Biophys

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Study of heavy ion radiation–induced effects on mice could provide insight into the human health risks of space radiation exposure. The purpose of the present study is to assess the relative biological effectiveness (RBE) of 12C and 28Si ion radiation, which has not been reported previously in the literature. Female C57BL/6J mice (n=15) were irradiated using 4 to 8 Gy of 28Si (300MeV/nucleon energy; LET 70 keV/μm) and 5 to 8 Gy of 12C (290MeV/nucleon energy; LET 13 keV/μm) ions. Post-exposure, mice were monitored regularly and their survival observed for 30 days. The LD50/30 dose (the dose at which 50% lethality occurred by 30-days post-exposure) was calculated from the survival curve and was used to determine the RBE of 28Si and 12C in relation to γ radiation. The LD50/30 for 28Si and 12C ion is 5.17 Gy and 7.34 Gy respectively and the RBE in relation to γ radiation (LD50/30 – 7.25 Gy) is 1.4 for 28Si and 0.99 for 12C. Determination of RBE of 28Si and 12C for survival in mice is not only important for space radiation risk estimate studies, but also has implications for HZE radiation in cancer therapy.

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The Relative Biological Effect of High-Z, High-LET Charged Particles for Spermatogonial Killing

Cited by 72 publications

References 15 publications

Late Effects of Heavy Charged Particles on the Fine Structure of the Mouse Coronary Artery

Late Effects of Heavy Charged Particles on the Fine Structure of the Mouse Coronary Artery

Relative Biological Effectiveness of Alpha-Particle Emitters In Vivo at Low Doses

Relative biological effectiveness of 12C and 28Si radiation in C57BL/6J mice

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