The Relative Anticaries Effectiveness of Three Fluoride-Containing Dentifrices in Puerto Rico

Abstract

The objective of this research was to evaluate the anticaries effectiveness of a low-dose (500 ppm F, low-NaF) sodium fluoride dentifrice, a high-dose (2,800 ppm F, high-NaF) sodium fluoride dentifrice and an experimental 0.454% stabilized stannous fluoride (1,100 ppm F) with sodium hexametaphosphate (SnF₂-HMP) dentifrice, each relative to a standard 1,100 ppm F sodium fluoride positive control dentifrice. Subjects (n = 955, with ∼239 per group) with a mean age of 10.6 (∼9–12 years) were randomly assigned to one of four dentifrice treatments. Two calibrated examiners independently measured visual-tactile caries as DMFS that was supplemented with a radiographic examination at baseline, 12 months and 24 months for each subject. Generally similar results were independently observed by both examiners at the conclusion of the 2-year study period. Considering all subjects that attended at least 60% of the supervised brushing sessions, statistically significantly less caries was observed in the high-NaF group compared to the control group. Similarly, statistically significantly less caries was observed in the SnF₂-HMP group as compared to the control group. Differences in caries increments between the low-NaF and control groups were not statistically significant. One of the examiners observed these same statistically significant differences after 1 year. In conclusion, the results of this clinical trial indicated that while no difference in caries increments was observed between the low-NaF and control groups, both the high-NaF and the SnF₂-HMP groups experienced significantly fewer lesions than the control group.

Remineralization of initial carious lesions in deciduous enamel after application of dentifrices of different fluoride concentrations

“…In contrast to our study, for permanent teeth Dunipace et al [7] and Wefel et al [16] found that mineral acquisition by initial white spot lesions increased with an increasing fluoride level. Recent studies showed that 500 ppm F -containing dentifrices led to a similar caries reduction compared to standard toothpastes in permanent teeth [12]. It has also been proven in vitro that at least 500 ppm are necessary to protect the enamel of permanent teeth from net demineralization [13].…”

Assessment of Autofluorescence to Detect the Remineralization Capabilities of Sodium Fluoride, Monofluorophosphate and Non-Fluoride Dentifrices

“…Supervised brushing has been a feature of a number of recently published abbreviated caries clinical trials [Biesbrock et al, 2003;Stookey et al, 2004]. The duration and frequency of the brushing varied across the studies but in each case it was described as an important component to achieving the discrimination of fluoride products within trials and other caries control programmes [Peterson, 1979;Curnow et al, 2002;Pitts and Stamm, 2004].…”

Comparative Evaluation of Stannous Fluoride vs Potassium Nitrate in the Management of Dentinal Hypersensitivity

“…Stannous fluoride (SnF 2 ) has been shown to be effective in the prevention of dental caries, [7] reduction of plaque formation, [8] control of gingivitis [9][10] and as suppression of breath malodor. [11] Research shows stannous fluoride is effective against dentinal hypersensitivity as well.…”

“…Miller et al [8] reported a tin-rich surface deposit forms in vitro and in situ with two weeks use of an anhydrous 0.4% stannous fluoride gel, providing nearly complete surface coverage and occlusion of the tubules. When the tubules are blocked, the stimulation of the mechanoreceptors does not occur, thus, preventing the pain response.…”